MicroRNAs Differentially Expressed in Actinic Keratosis and Healthy Skin Scrapings.
actinic keratosis
biomarkers
cSCC
microRNA
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
15 Jun 2023
15 Jun 2023
Historique:
received:
09
05
2023
revised:
07
06
2023
accepted:
13
06
2023
medline:
28
6
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
epublish
Résumé
Actinic keratosis (AK) is a carcinoma in situ precursor of cutaneous squamous cell carcinoma (cSCC), the second most common cancer affecting the Caucasian population. AK is frequently present in the sun-exposed skin of the elderly population, UV radiation being the main cause of this cancer, and other risk factors contributing to AK incidence. The dysregulation of microRNAs (miRNAs) observed in different cancers leads to an improper expression of miRNA targets involved in several cellular pathways. The TaqMan Array Human MicroRNA Card assay for miRNA expression profiling was performed in pooled AK compared to healthy skin scraping samples from the same patients. Forty-three miRNAs were modulated in the AK samples. The expression of miR-19b (
Identifiants
pubmed: 37371814
pii: biomedicines11061719
doi: 10.3390/biomedicines11061719
pmc: PMC10296342
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Sapienza University of Rome
ID : Bando di Ateneo Sapienza-2020", Grant no. RM120172B8B7B997
Organisme : Istituto Superiore di Sanità
ID : not applicable
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