Breast Cancer with Brain Metastasis: Molecular Insights and Clinical Management.
biomarkers
brain metastasis
breast cancer
metastatic breast cancer
molecular profiling
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
26 05 2023
26 05 2023
Historique:
received:
02
05
2023
revised:
16
05
2023
accepted:
23
05
2023
medline:
29
6
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
epublish
Résumé
Breast cancer is the most frequently diagnosed malignancy worldwide and the leading cause of cancer-related death among women. Brain metastases are a primary contributor to mortality, as they often go undetected until late stages due to their dormant nature. Moreover, the clinical management of brain metastases is complicated by the relevant issue of blood-brain barrier penetration. The molecular pathways involved in the formation, progression, and colonization of primary breast tumors and subsequent brain metastases are diverse, posing significant hurdles due to the heterogeneous nature of breast cancer subtypes. Despite advancements in primary breast cancer treatments, the prognosis for patients with brain metastases remains poor. In this review, we aim to highlight the biological mechanisms of breast cancer brain metastases by evaluating multi-step genetic pathways and to discuss currently available and emerging treatment strategies to propose a prospective overview of the management of this complex disease.
Identifiants
pubmed: 37372340
pii: genes14061160
doi: 10.3390/genes14061160
pmc: PMC10298724
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Cancers (Basel). 2021 Sep 29;13(19):
pubmed: 34638378
Am Soc Clin Oncol Educ Book. 2017;37:45-56
pubmed: 28561683
J Neurooncol. 2023 Mar;162(1):45-57
pubmed: 36884200
Ann Oncol. 2021 Dec;32(12):1475-1495
pubmed: 34678411
Lancet. 2017 Dec 17;388(10063):2997-3005
pubmed: 27908454
J Clin Oncol. 2022 Feb 10;40(5):492-516
pubmed: 34932393
Eur J Cancer. 2022 Aug;171:25-42
pubmed: 35696887
Nat Rev Dis Primers. 2019 Jan 17;5(1):5
pubmed: 30655533
Semin Cancer Biol. 2004 Jun;14(3):149-54
pubmed: 15246049
Front Mol Biosci. 2022 Aug 26;9:894247
pubmed: 36090031
Neurobiol Dis. 2010 Jan;37(1):13-25
pubmed: 19664713
J Oncol Pharm Pract. 2022 Jul;28(5):1152-1156
pubmed: 35450470
Nat Cancer. 2021 May;2(5):498-502
pubmed: 35122016
Int J Mol Sci. 2020 Feb 21;21(4):
pubmed: 32098071
Science. 2017 Mar 17;355(6330):1152-1158
pubmed: 28302823
Nat Rev Clin Oncol. 2020 May;17(5):279-299
pubmed: 32080373
Nat Rev Clin Oncol. 2022 Dec;19(12):763-774
pubmed: 36253451
Nature. 2015 Nov 5;527(7576):100-104
pubmed: 26479035
Cells. 2022 Nov 09;11(22):
pubmed: 36428975
Cancer Cell. 2011 Apr 12;19(4):498-511
pubmed: 21481791
Eur J Cancer Prev. 2022 Sep 1;31(5):459-466
pubmed: 35088973
Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13247-52
pubmed: 21788516
Front Immunol. 2015 Aug 21;6:418
pubmed: 26347741
Lancet. 2020 Dec 5;396(10265):1817-1828
pubmed: 33278935
Cancer Res. 2019 Aug 15;79(16):4173-4183
pubmed: 31239270
Cancers (Basel). 2022 Feb 28;14(5):
pubmed: 35267561
Ann Biomed Eng. 2011 Aug;39(8):2223-2241
pubmed: 21556948
Int J Mol Sci. 2019 Jan 25;20(3):
pubmed: 30691046
EMBO J. 1996 May 15;15(10):2452-67
pubmed: 8665853
Genes (Basel). 2020 Jun 28;11(7):
pubmed: 32605290
Lancet Oncol. 2020 Apr;21(4):519-530
pubmed: 32171426
Ther Adv Med Oncol. 2020 Jun 30;12:1758835920936151
pubmed: 32655700
Cells. 2021 Jun 02;10(6):
pubmed: 34199522
Cancer Res. 2000 May 1;60(9):2504-11
pubmed: 10811132
Cancers (Basel). 2023 Mar 13;15(6):
pubmed: 36980630
Neuro Oncol. 2021 Jun 1;23(6):894-904
pubmed: 33367836
Cancer Res. 2008 Jul 15;68(14):5878-87
pubmed: 18632642
Adv Funct Mater. 2020 Apr 3;30(14):
pubmed: 32440263
NPJ Breast Cancer. 2022 Apr 7;8(1):46
pubmed: 35393462
Front Oncol. 2017 Dec 11;7:298
pubmed: 29312881
Expert Opin Investig Drugs. 2022 Jun;31(6):593-605
pubmed: 35311430
Cancer Manag Res. 2023 Mar 23;15:311-317
pubmed: 36994110
Anticancer Agents Med Chem. 2022;22(4):787-800
pubmed: 34229592
Lancet Oncol. 2020 Mar;21(3):345-357
pubmed: 32035020
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
N Engl J Med. 2022 Jul 21;387(3):217-226
pubmed: 35857659
Breast Cancer (Dove Med Press). 2022 Jan 10;14:1-13
pubmed: 35046721
Cancer Manag Res. 2020 Jan 30;12:675-686
pubmed: 32099464
BMC Cancer. 2018 Dec 7;18(1):1225
pubmed: 30526520
Ann Oncol. 2020 Oct;31(10):1350-1358
pubmed: 32634611
J Immunother Cancer. 2020 Nov;8(2):
pubmed: 33239417
Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):E2900-9
pubmed: 25991856
J Biol Chem. 1999 Oct 22;274(43):30557-62
pubmed: 10521438
Clin Breast Cancer. 2020 Feb;20(1):e54-e64
pubmed: 31447286
Breast Cancer Res. 2011;13(6):R125
pubmed: 22132754
Acta Pharm Sin B. 2023 Jan;13(1):359-371
pubmed: 36815053
Annu Rev Pathol. 2022 Jan 24;17:181-204
pubmed: 35073169
Breast Cancer Res. 2016 Apr 27;18(1):43
pubmed: 27117582
J Biol Chem. 2007 Nov 9;282(45):32689-98
pubmed: 17823122
Ann Oncol. 2019 Mar 1;30(3):397-404
pubmed: 30475950
Cell Rep. 2020 Jan 21;30(3):755-770.e6
pubmed: 31968251
Front Oncol. 2020 Apr 02;10:422
pubmed: 32300557
J Clin Oncol. 2020 Aug 10;38(23):2610-2619
pubmed: 32468955
BMC Cancer. 2021 Oct 28;21(1):1152
pubmed: 34706703
ESMO Open. 2022 Oct;7(5):100561
pubmed: 36084395
Front Oncol. 2023 Feb 20;13:1139372
pubmed: 36890829
Neuro Oncol. 2020 Nov 26;22(11):1625-1636
pubmed: 32386414
J Biol Chem. 2015 Apr 10;290(15):9842-54
pubmed: 25691572
Nat Med. 2022 Sep;28(9):1840-1847
pubmed: 35941372
Lancet Oncol. 2013 May;14(6):461-71
pubmed: 23602601
Sci Rep. 2023 Feb 22;13(1):3108
pubmed: 36813833
Br J Cancer. 2021 Oct;125(8):1056-1067
pubmed: 34226684
Lancet. 2021 May 8;397(10286):1750-1769
pubmed: 33812473
J Oncol Pract. 2018 Jul;14(7):437-441
pubmed: 29920138
Front Biosci (Elite Ed). 2016 Jan 01;8(2):245-63
pubmed: 26709660
Lancet Oncol. 2017 Jun;18(6):743-754
pubmed: 28526538
Eur J Cancer Prev. 2023 Jul 1;32(4):364-369
pubmed: 37038998
Ann Oncol. 2020 Nov;31(11):1526-1535
pubmed: 32828825
Oncogene. 2016 Dec 1;35(48):6246-6261
pubmed: 27157615
Breast. 2015 Aug;24(4):426-33
pubmed: 25881974
Lancet Oncol. 2022 Jul;23(7):851-864
pubmed: 35671774
Clin Transl Oncol. 2023 May;25(5):1218-1241
pubmed: 36897508
Int J Cancer. 2023 Aug 15;153(4):803-814
pubmed: 36971103
Ann Oncol. 2014 Jun;25(6):1116-21
pubmed: 24685829
Oncologist. 2020 Nov;25(11):943-953
pubmed: 32869930
J Appl Physiol (1985). 2013 Jan 1;114(1):19-27
pubmed: 23123353
Neuro Oncol. 2023 Jan 5;25(1):157-166
pubmed: 35639825
Cancers (Basel). 2022 Nov 30;14(23):
pubmed: 36497418
Crit Rev Oncol Hematol. 2022 Apr;172:103643
pubmed: 35217131
Neuro Oncol. 2022 Dec 1;24(12):2146-2158
pubmed: 35609559
Glia. 2018 Nov;66(11):2438-2455
pubmed: 30357946
Front Oncol. 2021 Mar 25;11:644737
pubmed: 33842357
Int J Mol Sci. 2020 Sep 03;21(17):
pubmed: 32899139
J Neurosci. 2003 May 15;23(10):4034-43
pubmed: 12764090
Cells. 2019 Sep 20;8(10):
pubmed: 31547193
Front Oncol. 2023 Feb 20;13:1003565
pubmed: 36890831
Cancers (Basel). 2021 Aug 05;13(16):
pubmed: 34439105
Gulf J Oncolog. 2021 Jan;1(35):36-41
pubmed: 33716211
BMC Cancer. 2019 Nov 12;19(1):1091
pubmed: 31718602
Cancer Metastasis Rev. 2020 Sep;39(3):711-720
pubmed: 32399646
Front Oncol. 2023 Jan 25;13:978985
pubmed: 36761968
Nature. 2009 Jun 18;459(7249):1005-9
pubmed: 19421193
Nature. 2016 Apr 14;532(7598):195-200
pubmed: 27027288
BMC Cancer. 2018 Sep 29;18(1):935
pubmed: 30268112
Sci Transl Med. 2017 May 24;9(391):
pubmed: 28539475
Int J Mol Med. 2017 Sep;40(3):755-761
pubmed: 28713912
J Exp Med. 2003 Jun 2;197(11):1467-76
pubmed: 12782713
Ann Oncol. 2021 Aug;32(8):994-1004
pubmed: 34219000
ESMO Open. 2022 Dec;7(6):100636
pubmed: 36423363
Cell Rep. 2017 May 9;19(6):1189-1201
pubmed: 28494868
Clin Transl Oncol. 2014 May;16(5):436-46
pubmed: 24277572
Front Mol Biosci. 2022 Mar 15;9:834651
pubmed: 35372498
Nat Rev Cancer. 2002 Aug;2(8):563-72
pubmed: 12154349
N Engl J Med. 2020 Feb 13;382(7):597-609
pubmed: 31825569
Cancer Discov. 2011 Nov;1(6):481-6
pubmed: 22348200
Ecancermedicalscience. 2020 Dec 03;14:1150
pubmed: 33574895
J Clin Oncol. 2022 Oct 1;40(28):3246-3256
pubmed: 35584336
Histopathology. 2017 May;70(6):906-917
pubmed: 28072477
JCO Precis Oncol. 2020 May 27;4:
pubmed: 32923889
J Immunother Cancer. 2020 Aug;8(2):
pubmed: 32859740
J Med Genet. 2018 Jul;55(7):431-441
pubmed: 29929997
Breast. 2023 Jun;69:312-322
pubmed: 36996620
Gland Surg. 2020 Oct;9(5):1328-1337
pubmed: 33224807
Cancers (Basel). 2020 Jun 17;12(6):
pubmed: 32560361
Nat Med. 2018 Jul;24(7):1024-1035
pubmed: 29892069
Lancet Oncol. 2016 Jul;17(7):976-983
pubmed: 27267608
Oncology. 2023;101(4):262-269
pubmed: 36809751
Cell. 2014 Feb 27;156(5):1002-16
pubmed: 24581498
Neurooncol Adv. 2022 Sep 30;4(1):vdac154
pubmed: 36299795
J Chin Med Assoc. 2023 Feb 1;86(2):207-219
pubmed: 36652567
Am J Pathol. 2013 Jul;183(1):83-95
pubmed: 23665199
Cells. 2023 Mar 08;12(6):
pubmed: 36980181
Front Oncol. 2022 Jun 27;12:905065
pubmed: 35832552
Oncologist. 2021 Oct;26(10):835-844
pubmed: 34105210
Expert Opin Investig Drugs. 2022 Jun;31(6):567-591
pubmed: 35240902
Br J Pharmacol. 2023 Feb 12;:
pubmed: 36775813
N Engl J Med. 2018 Aug 23;379(8):753-763
pubmed: 30110579
Oncogene. 2016 Jun 2;35(22):2881-92
pubmed: 26411365