The Thyroid Hormone Axis and Female Reproduction.
PCOS
female reproduction
hypothyroidism
pregnancy
thyroid
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
06 Jun 2023
06 Jun 2023
Historique:
received:
02
05
2023
revised:
24
05
2023
accepted:
26
05
2023
medline:
29
6
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
epublish
Résumé
Thyroid function affects multiple sites of the female hypothalamic-pituitary gonadal (HPG) axis. Disruption of thyroid function has been linked to reproductive dysfunction in women and is associated with menstrual irregularity, infertility, poor pregnancy outcomes, and gynecological conditions such as premature ovarian insufficiency and polycystic ovarian syndrome. Thus, the complex molecular interplay between hormones involved in thyroid and reproductive functions is further compounded by the association of certain common autoimmune states with disorders of the thyroid and the HPG axes. Furthermore, in prepartum and intrapartum states, even relatively minor disruptions have been shown to adversely impact maternal and fetal outcomes, with some differences of opinion in the management of these conditions. In this review, we provide readers with a foundational understanding of the physiology and pathophysiology of thyroid hormone interactions with the female HPG axis. We also share clinical insights into the management of thyroid dysfunction in reproductive-aged women.
Identifiants
pubmed: 37372963
pii: ijms24129815
doi: 10.3390/ijms24129815
pmc: PMC10298303
pii:
doi:
Substances chimiques
Thyroid Hormones
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIEHS NIH HHS
ID : Intramural Research Program
Pays : United States
Références
Eur J Endocrinol. 2009 Dec;161(6):895-902
pubmed: 19666698
Reprod Domest Anim. 2011 Feb;46(1):e7-16
pubmed: 20403130
Int J Fertil Steril. 2014 Jan;7(4):281-90
pubmed: 24520498
J Endocrinol. 1995 Jul;146(1):87-94
pubmed: 7561625
J Clin Endocrinol Metab. 2015 Nov;100(11):3975-4011
pubmed: 26444994
Cell Tissue Res. 2020 Feb;379(2):291-300
pubmed: 31463706
Endocrinology. 1978 Oct;103(4):1164-72
pubmed: 744139
Int J Mol Med. 2008 Nov;22(5):683-9
pubmed: 18949391
J Clin Med. 2020 Jun 01;9(6):
pubmed: 32492950
Brain Res. 2020 Feb 1;1728:146574
pubmed: 31790683
Front Immunol. 2019 Oct 01;10:2349
pubmed: 31681268
Neurosci Res. 2017 Apr;117:35-41
pubmed: 27902923
Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11324-9
pubmed: 19541621
J Clin Invest. 1970 Oct;49(10):1922-9
pubmed: 4990073
Int J Mol Sci. 2022 Dec 09;23(24):
pubmed: 36555258
Biochem Biophys Res Commun. 1971 May 7;43(3):516-23
pubmed: 4327442
J Mol Endocrinol. 2009 Jul;43(1):19-27
pubmed: 19336534
Thyroid. 2005 Jan;15(1):54-9
pubmed: 15687824
Thyroid. 2004 Dec;14(12):1084-90
pubmed: 15650363
Ann N Y Acad Sci. 1997 Jun 17;816:280-4
pubmed: 9238278
Front Endocrinol (Lausanne). 2022 Mar 08;13:823710
pubmed: 35355565
Front Immunol. 2019 Mar 26;10:573
pubmed: 30972068
Chin J Physiol. 2013 Oct 31;56(5):298-305
pubmed: 24032715
Thyroid. 2009 May;19(5):443-50
pubmed: 19415994
Nihon Naibunpi Gakkai Zasshi. 1975 Mar 20;51(3):161-5
pubmed: 808433
Indian J Surg Oncol. 2021 Dec;12(Suppl 2):343-347
pubmed: 35035167
Thyroid. 2019 Oct;29(10):1465-1474
pubmed: 31407629
Eur J Endocrinol. 2010 Jul;163(1):63-7
pubmed: 20392823
Andrologia. 2012 Aug;44(4):217-25
pubmed: 22211273
Cell Metab. 2011 Dec 7;14(6):780-90
pubmed: 22100407
Pathol Res Pract. 2015 Mar;211(3):226-34
pubmed: 25499719
Medicine (Baltimore). 2016 Mar;95(10):e2975
pubmed: 26962803
Hum Reprod. 2005 Apr;20(4):864-71
pubmed: 15665014
Reprod Biomed Online. 2010 Jun;20(6):751-8
pubmed: 20378412
Nat Rev Endocrinol. 2020 Aug;16(8):407-420
pubmed: 32427949
J Clin Endocrinol Metab. 2020 Aug 1;105(8):
pubmed: 32593174
Int J Dev Biol. 2010;54(2-3):355-66
pubmed: 19924632
Cureus. 2020 May 15;12(5):e8142
pubmed: 32550062
N Engl J Med. 1986 Jul 3;315(1):24-8
pubmed: 2423874
Neuro Endocrinol Lett. 2020 Apr;41(1):1-9
pubmed: 32338855
Curr Opin Endocr Metab Res. 2021 Apr;17:8-14
pubmed: 34322645
JAMA. 2017 Dec 12;318(22):2190-2198
pubmed: 29234808
Front Neuroendocrinol. 2010 Apr;31(2):134-56
pubmed: 20074584
Iran J Basic Med Sci. 2022 Sep;25(9):1077-1083
pubmed: 36246072
Arch Surg. 1981 Feb;116(2):207-10
pubmed: 6258538
Mol Hum Reprod. 1997 Jul;3(7):555-62
pubmed: 9268132
Front Endocrinol (Lausanne). 2022 Oct 10;13:1023635
pubmed: 36299456
Exp Physiol. 2018 May 1;103(5):683-692
pubmed: 29485241
J Clin Invest. 2012 Sep;122(9):3035-43
pubmed: 22945636
J Clin Invest. 2002 Jul;110(2):161-4
pubmed: 12122107
Thyroid. 2017 Mar;27(3):440-450
pubmed: 28049387
Nihon Sanka Fujinka Gakkai Zasshi. 1991 Nov;43(11):1533-8
pubmed: 1940550
Front Endocrinol (Lausanne). 2018 Nov 27;9:700
pubmed: 30542323
Health Equity. 2019 Jul 11;3(1):328-335
pubmed: 31338485
Acta Endocrinol (Copenh). 1982 Aug;100(4):504-11
pubmed: 6812340
Obstet Gynecol. 1988 Jul;72(1):108-12
pubmed: 3380497
J Endocrinol Invest. 2020 Jun;43(6):821-831
pubmed: 31894536
Mol Cell Endocrinol. 2014 Mar 25;384(1-2):23-31
pubmed: 24412804
Endocrinology. 1981 Jun;108(6):2346-51
pubmed: 7227309
Int J Mol Sci. 2022 Dec 01;23(23):
pubmed: 36499435
Front Endocrinol (Lausanne). 2022 Oct 31;13:1025267
pubmed: 36387911
J Clin Endocrinol Metab. 2001 Jul;86(7):3284-91
pubmed: 11443202
Endocrinology. 2005 Jul;146(7):2963-75
pubmed: 15817667
Front Endocrinol (Lausanne). 2023 Jan 17;13:1044655
pubmed: 36733802
Fertil Steril. 2017 Oct 25;:
pubmed: 29102040
J Biol Rhythms. 2013 Jun;28(3):193-200
pubmed: 23735498
Sci Rep. 2017 Apr 21;7(1):1042
pubmed: 28432332
J Clin Endocrinol Metab. 2006 Jul;91(7):2587-91
pubmed: 16621910
Eur Thyroid J. 2019 Jun;8(3):152-158
pubmed: 31259157
Animals (Basel). 2022 Dec 14;12(24):
pubmed: 36552453
J Clin Endocrinol Metab. 2021 Mar 8;106(3):e1071-e1083
pubmed: 33211867
Best Pract Res Clin Endocrinol Metab. 2004 Jun;18(2):133-52
pubmed: 15157832
Free Radic Biol Med. 2022 Nov 20;193(Pt 1):59-79
pubmed: 36206932
Indian J Endocrinol Metab. 2016 Jan-Feb;20(1):108-13
pubmed: 26904478
Endocrinology. 2020 Jun 1;161(6):
pubmed: 32242219
Endocrinology. 2006 Feb;147(2):816-26
pubmed: 16293665
J Clin Endocrinol Metab. 2009 May;94(5):1623-9
pubmed: 19190113
Reprod Fertil Dev. 2007;19(3):498-509
pubmed: 17394799
Reproduction. 2007 Jan;133(1):197-205
pubmed: 17244746
Fertil Steril. 1993 Jun;59(6):1187-90
pubmed: 8495763
Arch Androl. 1997 Jan-Feb;38(1):85-92
pubmed: 9017126
Clin Endocrinol (Oxf). 2013 Aug;79(2):152-62
pubmed: 23600900
Indian J Endocrinol Metab. 2018 Jul-Aug;22(4):479-484
pubmed: 30148093
J Clin Endocrinol Metab. 2012 Aug;97(8):2543-65
pubmed: 22869843
Regul Pept. 2000 Aug 25;92(1-3):25-9
pubmed: 11024561
Thyroid. 2017 Sep;27(9):1194-1200
pubmed: 28810821
J Obstet Gynaecol India. 2016 Apr;66(2):115-9
pubmed: 27046965
Hum Reprod. 2021 May 17;36(6):1621-1629
pubmed: 33569594
Clin Endocrinol (Oxf). 2022 Sep;97(3):347-354
pubmed: 35261044
Ann N Y Acad Sci. 2010 Sep;1205:33-8
pubmed: 20840250
Aging (Albany NY). 2011 Nov;3(11):1092-7
pubmed: 22081645
Peptides. 2018 Sep;107:25-31
pubmed: 30076861
N Engl J Med. 2019 Apr 4;380(14):1316-1325
pubmed: 30907987
Thyroid. 2014 Dec;24(12):1670-751
pubmed: 25266247
J Clin Endocrinol Metab. 2005 May;90(5):2666-74
pubmed: 15705921
Life Sci. 2019 Aug 1;230:111-120
pubmed: 31129141
Int J Endocrinol. 2014;2014:982705
pubmed: 24678319
Biol Reprod. 2018 Nov 1;99(5):907-921
pubmed: 29767691
JAMA. 2019 Aug 20;322(7):632-641
pubmed: 31429897
Front Endocrinol (Lausanne). 2019 Aug 06;10:522
pubmed: 31447778
Eur J Intern Med. 2016 Nov;35:106-110
pubmed: 27473607
Reprod Fertil Dev. 1996;8(6):961-7
pubmed: 8896030
Ginekol Pol. 2022 Mar 22;:
pubmed: 35315007
Biomed Res Int. 2017;2017:3795950
pubmed: 28133606
Lancet Diabetes Endocrinol. 2013 Nov;1(3):238-49
pubmed: 24622372
Eur J Endocrinol. 1995 May;132(5):594-8
pubmed: 7749500
Ann Natl Acad Med Sci. 2020 Jan;56(1):30-37
pubmed: 32655207
Indian J Endocrinol Metab. 2014 Jan;18(1):23-31
pubmed: 24701426
Placenta. 2015 Jan;36(1):97-9
pubmed: 25468542
Korean J Intern Med. 2018 Jul;33(4):753-762
pubmed: 28859466
Endocrinology. 1982 May;110(5):1773-9
pubmed: 7075537
Endokrynol Pol. 2022;73(4):645-679
pubmed: 36059162
Thyroid Res. 2021 Jul 21;14(1):18
pubmed: 34289872
J Clin Invest. 2012 Oct;122(10):3791-5
pubmed: 23006326
JAMA Intern Med. 2020 Jan 1;180(1):54-61
pubmed: 31633736
J Endocrinol. 2003 Jan;176(1):7-12
pubmed: 12525244
BMC Endocr Disord. 2019 May 7;19(1):47
pubmed: 31064360
Mol Endocrinol. 1997 Jun;11(7):986-96
pubmed: 9178758
J Clin Endocrinol Metab. 1990 Aug;71(2):276-87
pubmed: 2116437
Lancet Diabetes Endocrinol. 2022 Apr;10(4):243-252
pubmed: 35255260
J Thyroid Res. 2013;2013:182472
pubmed: 23691429
J Womens Health (Larchmt). 2019 Jun;28(6):842-848
pubmed: 30855205
J Clin Endocrinol Metab. 2021 Jul 13;106(8):2436-2446
pubmed: 33839790
Obstet Gynecol. 2005 Feb;105(2):239-45
pubmed: 15684146
Eur J Obstet Gynecol Reprod Biol. 2021 May;260:85-98
pubmed: 33744505
J Clin Diagn Res. 2016 Oct;10(10):QC10-QC12
pubmed: 27891401
J Endocrinol Invest. 2021 May;44(5):883-890
pubmed: 33332019
Animals (Basel). 2021 Sep 08;11(9):
pubmed: 34573602
Endocrinology. 1987 Oct;121(4):1233-41
pubmed: 3115761
Endocrinol Metab Clin North Am. 2019 Sep;48(3):547-556
pubmed: 31345522
Int J Environ Res Public Health. 2022 Oct 13;19(20):
pubmed: 36293757
Thyroid. 2004 Nov;14(11):926-32
pubmed: 15671771
Chin J Physiol. 2018 May 10;61(3):152-162
pubmed: 29742817
Int J Endocrinol Metab. 2022 Jul 19;20(3):e120949
pubmed: 36425270
Menopause. 2021 Jun 28;28(9):1044-1052
pubmed: 34183565
N Engl J Med. 1999 Feb 11;340(6):424-9
pubmed: 9971866
Thyroid Res. 2020 Jun 27;13:11
pubmed: 32607131
Endocr Connect. 2018 Sep 1;7(11):1158-1167
pubmed: 30352422
Indian J Med Res. 2020 Nov;152(Suppl 1):S89
pubmed: 35345140
Front Endocrinol (Lausanne). 2021 Dec 10;12:797423
pubmed: 34956101
N Engl J Med. 2001 Jun 7;344(23):1743-9
pubmed: 11396440
Thyroid. 2018 Oct;28(10):1349-1358
pubmed: 29943679
Cureus. 2019 Nov 16;11(11):e6173
pubmed: 31890380
Endocrinology. 1994 Mar;134(3):1577-80
pubmed: 8119200
J Clin Endocrinol Metab. 1995 Jan;80(1):276-9
pubmed: 7829625
Endocrinology. 2001 May;142(5):2123-8
pubmed: 11316780
Paediatr Perinat Epidemiol. 2018 May;32(3):225-234
pubmed: 29517803
J Clin Endocrinol Metab. 1999 Aug;84(8):2883-7
pubmed: 10443695
J Biol Chem. 2000 Nov 17;275(46):36124-33
pubmed: 10967095
Vitam Horm. 2018;106:19-44
pubmed: 29407435
Endocrinology. 2001 Jun;142(6):2606-13
pubmed: 11356711
Eur J Endocrinol. 2021 Apr;184(4):R123-R135
pubmed: 33460394
Fertil Steril. 1987 Aug;48(2):318-20
pubmed: 3111894
eNeuro. 2022 Mar 3;9(2):
pubmed: 35165199
PLoS One. 2015 Jul 01;10(7):e0131198
pubmed: 26132582
Ann Saudi Med. 2011 Mar-Apr;31(2):145-51
pubmed: 21403408
Thyroid. 2017 Nov;27(11):1341-1346
pubmed: 29091573
Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11894-11899
pubmed: 31142643
J Endocrinol Invest. 1991 Jan;14(1):1-9
pubmed: 2045620
Fertil Steril. 2011 Jan;95(1):230-7, 237.e1-2
pubmed: 20691434
Lancet Diabetes Endocrinol. 2020 Jun;8(6):501-510
pubmed: 32445737
Front Endocrinol (Lausanne). 2013 Nov 25;4:184
pubmed: 24324459
Am J Obstet Gynecol. 1983 Jun 15;146(4):380-3
pubmed: 6305196
Front Endocrinol (Lausanne). 2022 Jun 24;13:800257
pubmed: 35813653
J Ovarian Res. 2017 Mar 16;10(1):19
pubmed: 28302175
Obstet Gynecol. 2020 Jun;135(6):1496-1499
pubmed: 32443078
Reprod Med Biol. 2021 Dec 07;21(1):e12427
pubmed: 34934402
Thyroid. 2016 Oct;26(10):1343-1421
pubmed: 27521067
Acta Endocrinol (Copenh). 1992 Aug;127(2):152-60
pubmed: 1326831
Eur J Obstet Gynecol Reprod Biol. 2021 Apr;259:53-59
pubmed: 33588237
Thyroid. 2021 Sep;31(9):1305-1315
pubmed: 34210154
J Clin Endocrinol Metab. 2021 Mar 8;106(3):e1316-e1331
pubmed: 33236107
North Clin Istanb. 2023 Feb 20;10(1):48-52
pubmed: 36910433
Metabolism. 1983 Feb;32(2):142-5
pubmed: 6298566
Thyroid. 2016 Jan;26(1):1-133
pubmed: 26462967
Gynecol Endocrinol. 2020 Jun;36(6):501-507
pubmed: 31793357
PLoS One. 2009 Dec 22;4(12):e8400
pubmed: 20027225
Front Endocrinol (Lausanne). 2019 May 17;10:303
pubmed: 31156553
J Clin Endocrinol Metab. 2005 Jan;90(1):323-7
pubmed: 15509645
Biol Reprod. 2016 Apr;94(4):90
pubmed: 26962119
Endocr J. 2010;57(12):1017-22
pubmed: 20938101
Clin Endocrinol (Oxf). 2017 May;86(5):731-738
pubmed: 28186349
BMC Pregnancy Childbirth. 2020 Aug 26;20(1):491
pubmed: 32847542
Hum Reprod. 2017 Apr 1;32(4):915-922
pubmed: 28333271
Endocrinology. 2009 Dec;150(12):5566-74
pubmed: 19833718
Cureus. 2021 Apr 16;13(4):e14517
pubmed: 34007768
Endocrinology. 2019 May 1;160(5):1323-1332
pubmed: 30901026
Biology (Basel). 2022 Mar 02;11(3):
pubmed: 35336768
Vascul Pharmacol. 2018 Sep;108:36-45
pubmed: 29751093
J Thyroid Res. 2011;2011:843591
pubmed: 21876837
Front Endocrinol (Lausanne). 2019 Jul 09;10:446
pubmed: 31354624
J Neuroendocrinol. 2013 Oct;25(10):876-86
pubmed: 23927071
Endocrinology. 1976 Sep;99(3):713-9
pubmed: 782856
Endocrinology. 1977 Mar;100(3):807-13
pubmed: 122599
J Clin Endocrinol Metab. 2002 Feb;87(2):489-99
pubmed: 11836274
Fertil Steril. 2013 Feb;99(2):588-92
pubmed: 23103018
Autoimmunity. 1990;6(3):211-4
pubmed: 2129779
Acta Endocrinol (Copenh). 1989 Jul;121(1):95-100
pubmed: 2500822
N Engl J Med. 2003 Aug 21;349(8):760-6
pubmed: 12930928
J Clin Transl Endocrinol. 2022 Jul 14;29:100302
pubmed: 35898802
Endocr Connect. 2022 Apr 26;11(4):
pubmed: 35294399
Arch Endocrinol Metab. 2016 Nov-Dec;60(6):587-595
pubmed: 27901187
Obstet Gynecol. 2008 Jul;112(1):85-92
pubmed: 18591312
J Anat. 1996 Apr;188 ( Pt 2):383-93
pubmed: 8621338
Ann Intern Med. 1968 Sep;69(3):537-40
pubmed: 5673172
Horm Res. 1991;35 Suppl 1:5-12
pubmed: 1752606
Neuroendocrinology. 2003 Dec;78(6):321-30
pubmed: 14688445
Am J Obstet Gynecol. 2023 Feb;228(2):213.e1-213.e22
pubmed: 36414993
Int J Mol Sci. 2021 Mar 05;22(5):
pubmed: 33807517
Thyroid. 2002 Nov;12(11):997-1001
pubmed: 12490077
Acta Endocrinol (Copenh). 1982 Dec;101(4):531-7
pubmed: 7158229
Thyroid. 2014 Nov;24(11):1575-93
pubmed: 25087834
J Recept Signal Transduct Res. 2022 Dec;42(6):608-613
pubmed: 36137227
Clin Endocrinol (Oxf). 2020 Dec;93(6):721-728
pubmed: 32657434
Physiol Rev. 2020 Jul 1;100(3):1149-1179
pubmed: 32031903
J Physiol Pharmacol. 2014 Feb;65(1):145-51
pubmed: 24622839
Endocrine. 2012 Dec;42(3):684-93
pubmed: 22695985
Endocrinology. 1997 Nov;138(11):5039-47
pubmed: 9348236
Endocrinology. 2012 Dec;153(12):5918-27
pubmed: 23038740
J Neuroendocrinol. 2016 Feb;28(2):12344
pubmed: 26644229
J Am Coll Radiol. 2017 May;14(5):587-595
pubmed: 28372962
J Clin Endocrinol Metab. 2013 Nov;98(11):4382-90
pubmed: 24037884
Gynecol Obstet Invest. 2018;83(2):105-115
pubmed: 30025406
Hum Reprod Update. 2019 May 1;25(3):344-361
pubmed: 30951172
F S Rep. 2021 Jul 24;2(4):433-439
pubmed: 34934984
Clin Sci (Lond). 1982 Feb;62(2):215-20
pubmed: 7053919
Endocrinology. 2003 Oct;144(10):4484-91
pubmed: 12960084
Endocrinology. 2018 Feb 1;159(2):1188-1198
pubmed: 29319820
Clin Endocrinol (Oxf). 1993 Apr;38(4):345-50
pubmed: 8319364
J Thromb Haemost. 2018 Apr;16(4):634-645
pubmed: 29573126
Thyroid. 2017 Mar;27(3):315-389
pubmed: 28056690
Prz Menopauzalny. 2018 Sep;17(3):105-108
pubmed: 30357004
Endocrinology. 2013 Jan;154(1):340-50
pubmed: 23239814