Immunomodulatory Role of Interferons in Viral and Bacterial Infections.
Epstein–Barr virus
IFN-α
IFN-β
IFN-γ
SARS-CoV coronavirus
bacterial infections
hepatitis C virus
herpes simplex virus
immune system
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
14 Jun 2023
14 Jun 2023
Historique:
received:
10
05
2023
revised:
02
06
2023
accepted:
09
06
2023
medline:
29
6
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
epublish
Résumé
Interferons are a group of immunomodulatory substances produced by the human immune system in response to the presence of pathogens, especially during viral and bacterial infections. Their remarkably diverse mechanisms of action help the immune system fight infections by activating hundreds of genes involved in signal transduction pathways. In this review, we focus on discussing the interplay between the IFN system and seven medically important and challenging viruses (herpes simplex virus (HSV), influenza, hepatitis C virus (HCV), lymphocytic choriomeningitis virus (LCMV), human immunodeficiency virus (HIV), Epstein-Barr virus (EBV), and SARS-CoV coronavirus) to highlight the diversity of viral strategies. In addition, the available data also suggest that IFNs play an important role in the course of bacterial infections. Research is currently underway to identify and elucidate the exact role of specific genes and effector pathways in generating the antimicrobial response mediated by IFNs. Despite the numerous studies on the role of interferons in antimicrobial responses, many interdisciplinary studies are still needed to understand and optimize their use in personalized therapeutics.
Identifiants
pubmed: 37373262
pii: ijms241210115
doi: 10.3390/ijms241210115
pmc: PMC10298684
pii:
doi:
Substances chimiques
Interferons
9008-11-1
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Science Center
ID : 2021/41/B/NZ6/01765
Organisme : Medical University of Lublin
ID : Pbsd 167
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