The Brain at High Altitude: From Molecular Signaling to Cognitive Performance.
EPO
HIF
acclimatization
carotid body
cognition
hypoxia
neurogenesis
synaptogenesis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
15 Jun 2023
15 Jun 2023
Historique:
received:
27
04
2023
revised:
13
06
2023
accepted:
13
06
2023
medline:
29
6
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
epublish
Résumé
The brain requires over one-fifth of the total body oxygen demand for normal functioning. At high altitude (HA), the lower atmospheric oxygen pressure inevitably challenges the brain, affecting voluntary spatial attention, cognitive processing, and attention speed after short-term, long-term, or lifespan exposure. Molecular responses to HA are controlled mainly by hypoxia-inducible factors. This review aims to summarize the cellular, metabolic, and functional alterations in the brain at HA with a focus on the role of hypoxia-inducible factors in controlling the hypoxic ventilatory response, neuronal survival, metabolism, neurogenesis, synaptogenesis, and plasticity.
Identifiants
pubmed: 37373327
pii: ijms241210179
doi: 10.3390/ijms241210179
pmc: PMC10299449
pii:
doi:
Substances chimiques
Oxygen
S88TT14065
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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