Insights into Endothelin Receptors in Pulmonary Hypertension.
antagonist
drug target
endothelin receptor
pulmonary hypertension
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
16 Jun 2023
16 Jun 2023
Historique:
received:
25
04
2023
revised:
12
06
2023
accepted:
14
06
2023
medline:
29
6
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
epublish
Résumé
Pulmonary hypertension (PH) is a disease which affects the cardiopulmonary system; it is defined as a mean pulmonary artery pressure (mPAP) > 20 mmHg as measured by right heart catheterization at rest, and is caused by complex and diverse mechanisms. In response to stimuli such as hypoxia and ischemia, the expression and synthesis of endothelin (ET) increase, leading to the activation of various signaling pathways downstream of it and producing effects such as the induction of abnormal vascular proliferation during the development of the disease. This paper reviews the regulation of endothelin receptors and their pathways in normal physiological processes and disease processes, and describes the mechanistic roles of ET receptor antagonists that are currently approved and used in clinical studies. Current clinical researches on ET are focused on the development of multi-target combinations and novel delivery methods to improve efficacy and patient compliance while reducing side effects. In this review, future research directions and trends of ET targets are described, including monotherapy and precision medicine.
Identifiants
pubmed: 37373355
pii: ijms241210206
doi: 10.3390/ijms241210206
pmc: PMC10299084
pii:
doi:
Substances chimiques
Receptors, Endothelin
0
Endothelin Receptor Antagonists
0
Endothelins
0
Endothelin-1
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : 82073853
Organisme : National Natural Science Foundation of China
ID : 82141204
Organisme : CAMS Innovation Fund for Medical Sciences
ID : 2022-I2M-JB-010
Organisme : CAMS Innovation Fund for Medical Sciences
ID : 2021-I2M-1-005
Références
J Appl Physiol (1985). 2007 Feb;102(2):762-71
pubmed: 17082362
Front Physiol. 2019 Jun 12;10:729
pubmed: 31244683
J Am Coll Cardiol. 2017 Jan 17;69(2):236-243
pubmed: 28081831
J Ethnopharmacol. 2022 Feb 10;284:114812
pubmed: 34752899
Pharmacol Rev. 2016 Apr;68(2):357-418
pubmed: 26956245
Cardiol Clin. 2020 May;38(2):243-255
pubmed: 32284101
Pulm Pharmacol Ther. 2018 Apr;49:140-146
pubmed: 29501590
Nat Commun. 2018 Nov 21;9(1):4906
pubmed: 30464173
PLoS One. 2014 Jun 23;9(6):e100310
pubmed: 24956016
Annu Rev Pharmacol Toxicol. 2001;41:851-76
pubmed: 11264479
Front Pharmacol. 2022 Jun 20;13:920222
pubmed: 35795553
Basic Clin Pharmacol Toxicol. 2018 Aug;123(2):103-113
pubmed: 29719121
J Clin Pharm Ther. 2022 Feb;47(2):146-156
pubmed: 34319626
J Biol Chem. 1989 Sep 5;264(25):14954-9
pubmed: 2670930
Respir Med. 2018 Oct;143:139-146
pubmed: 30261985
Eur J Pharmacol. 1999 Jul 9;376(3):233-8
pubmed: 10448881
Peptides. 2019 Jan;111:77-88
pubmed: 30352269
Bioorg Med Chem. 2015 Feb 15;23(4):657-67
pubmed: 25614116
J Appl Physiol (1985). 2020 Jun 1;128(6):1497-1505
pubmed: 32324474
Eur Respir J. 2019 Jan 24;53(1):
pubmed: 30552088
Chem Biol Interact. 2022 Dec 1;368:110203
pubmed: 36183783
Am J Physiol Regul Integr Comp Physiol. 2016 Mar 1;310(5):R388-97
pubmed: 26702154
Semin Fetal Neonatal Med. 2022 Aug;27(4):101347
pubmed: 35473693
Redox Biol. 2019 Feb;21:101099
pubmed: 30660098
Eur Respir J. 2019 Jan 24;53(1):
pubmed: 30545968
Environ Sci Pollut Res Int. 2020 Jul;27(21):26163-26171
pubmed: 32361974
J Pharmacol Exp Ther. 1994 Oct;271(1):429-37
pubmed: 7965744
Hypertension. 2019 Dec;74(6):1232-1265
pubmed: 31679425
Heart. 2006 Jun;92(6):798-803
pubmed: 16339819
J Pharmacol Exp Ther. 2019 Jul;370(1):54-61
pubmed: 30992315
J Biol Chem. 2000 Jun 9;275(23):17596-604
pubmed: 10747877
Pharmacol Ther. 2020 Oct;214:107576
pubmed: 32417272
Front Immunol. 2022 Jun 09;13:895501
pubmed: 35757687
J Cardiovasc Thorac Res. 2019;11(3):189-195
pubmed: 31579458
Equine Vet J. 2001 Jul;33(4):345-53
pubmed: 11469766
Br J Pharmacol. 2021 Jan;178(1):6-30
pubmed: 32034759
Cell. 2017 Jul 27;170(3):522-533.e15
pubmed: 28753427
Respir Res. 2022 Jan 11;23(1):6
pubmed: 35016680
Clin Perinatol. 1995 Jun;22(2):387-403
pubmed: 7671544
Int J Mol Med. 2021 Feb;47(2):595-606
pubmed: 33416126
Eur Respir J. 2009 Sep;34(3):770-1
pubmed: 19720812
Circ Res. 2022 Apr 29;130(9):1404-1422
pubmed: 35482836
Eur Rev Med Pharmacol Sci. 2018 Jul;22(14):4683-4690
pubmed: 30058708
Cell Death Differ. 2019 Nov;26(11):2371-2385
pubmed: 30804470
Eur Respir J. 2007 Aug;30(2):338-44
pubmed: 17504794
Lung. 2016 Oct;194(5):723-32
pubmed: 27506903
Front Endocrinol (Lausanne). 2021 May 21;12:661828
pubmed: 34093437
J Thorac Dis. 2019 Sep;11(Suppl 14):S1767-S1781
pubmed: 31632754
Am J Respir Crit Care Med. 2019 Oct 1;200(7):910-920
pubmed: 31042405
J Am Coll Cardiol. 2009 Jun 30;54(1 Suppl):S32-S42
pubmed: 19555857
Free Radic Biol Med. 2021 Jul;170:150-178
pubmed: 33450375
Am J Respir Cell Mol Biol. 2020 Sep;63(3):279-292
pubmed: 32453969
Eur Respir J. 2019 Dec 12;54(6):
pubmed: 31515405
Circulation. 2008 Jun 10;117(23):3010-9
pubmed: 18506008
Nat Rev Cardiol. 2019 Aug;16(8):491-502
pubmed: 30867577
J Cardiovasc Pharmacol. 1998;31 Suppl 1:S331-5
pubmed: 9595473
Am J Respir Crit Care Med. 2010 Dec 15;182(12):1554-62
pubmed: 20833821
Eur Respir J. 2018 Apr 4;51(4):
pubmed: 29545281
Ann N Y Acad Sci. 1994 Apr 18;714:101-8
pubmed: 8017758
Expert Opin Drug Discov. 2016;11(4):407-14
pubmed: 26901465
Eur J Pharmacol. 2021 Nov 5;910:174311
pubmed: 34245749
Eur Respir Rev. 2017 Jan 31;26(143):
pubmed: 28143879
Pediatr Res. 2002 Dec;52(6):913-21
pubmed: 12438670
Curr Opin Cell Biol. 2017 Apr;45:31-37
pubmed: 28232179
Circulation. 1998 Jan 27;97(3):234-6
pubmed: 9462522
Proc Natl Acad Sci U S A. 1988 Sep;85(18):6964-7
pubmed: 3045827
Annu Rev Physiol. 2021 Feb 10;83:551-576
pubmed: 33566674
J Hypertens. 2016 Jan;34(1):3-10
pubmed: 26556565
Circ Res. 2006 Sep 29;99(7):675-91
pubmed: 17008597
Respir Res. 2021 Jan 6;22(1):8
pubmed: 33407472
Circulation. 2014 Dec 9;130(24):2189-208
pubmed: 25602947
Eur Respir J. 2023 Jan 6;61(1):
pubmed: 36028254
Arterioscler Thromb Vasc Biol. 2020 Nov;40(11):2632-2648
pubmed: 32814441
Int J Environ Res Public Health. 2021 Feb 10;18(4):
pubmed: 33578749
Cell Signal. 2010 Nov;22(11):1615-25
pubmed: 20466059
Life (Basel). 2022 Oct 18;12(10):
pubmed: 36295062
JHEP Rep. 2022 Jul 04;4(9):100527
pubmed: 36035361
Curr Cardiol Rep. 2019 Nov 22;21(11):141
pubmed: 31758342
Eur Rev Med Pharmacol Sci. 2020 May;24(9):4988-4996
pubmed: 32432762
Nature. 1988 Mar 31;332(6163):411-5
pubmed: 2451132
J Pharmacol Exp Ther. 2008 Dec;327(3):736-45
pubmed: 18780830
Mayo Clin Proc. 1990 Nov;65(11):1441-55
pubmed: 2232899
Mayo Clin Proc. 2020 Sep;95(9):1978-1988
pubmed: 32861339
Expert Opin Drug Saf. 2012 Nov;11(6):1003-11
pubmed: 22861496
Biochem Biophys Res Commun. 1989 Jan 16;158(1):86-93
pubmed: 2536280
N Engl J Med. 2013 Aug 29;369(9):809-18
pubmed: 23984728
Clin Hemorheol Microcirc. 2019;71(1):3-8
pubmed: 29660902
FASEB J. 2017 Feb;31(2):650-662
pubmed: 27811062
Front Endocrinol (Lausanne). 2022 Apr 19;13:880002
pubmed: 35518926
Ann Thorac Surg. 1999 Nov;68(5):1714-21; discussion 1721-2
pubmed: 10585047
J Am Coll Cardiol. 2020 Dec 1;76(22):2671-2681
pubmed: 33243385
Eur Respir J. 2022 Jun 16;59(6):
pubmed: 34737219
J Vasc Res. 2010;47(1):16-22
pubmed: 19672104
Nature. 2016 Sep 15;537(7620):363-368
pubmed: 27595334
Am J Respir Cell Mol Biol. 2014 Mar;50(3):647-53
pubmed: 24156273
Proc Natl Acad Sci U S A. 1989 Apr;86(8):2863-7
pubmed: 2649896
Pathol Res Pract. 2020 Sep;216(9):153083
pubmed: 32825951
J Clin Invest. 1989 Feb;83(2):708-12
pubmed: 2536405
Br J Pharmacol. 2014 Dec;171(24):5555-72
pubmed: 25131455
Eur J Pharm Sci. 2009 Nov 5;38(4):384-8
pubmed: 19765655
J Appl Physiol (1985). 1995 Dec;79(6):2122-31
pubmed: 8847282
Cochrane Database Syst Rev. 2021 Mar 26;3:CD004434
pubmed: 33765691
Pulm Pharmacol Ther. 2000;13(2):87-97
pubmed: 10799286
Physiol Res. 2018 Jun 27;67(Suppl 1):S37-S54
pubmed: 29947527
Arch Med Sci. 2019 Jul 22;17(3):613-620
pubmed: 34025830
Am J Physiol Heart Circ Physiol. 2022 May 1;322(5):H702-H724
pubmed: 35213243
Reproduction. 2022 Mar 05;163(4):R71-R80
pubmed: 35167488
Am J Physiol Cell Physiol. 2019 Aug 1;317(2):C270-C276
pubmed: 31116583
Respir Res. 2021 Dec 14;22(1):312
pubmed: 34906150
Cardiovasc Res. 2017 Oct 1;113(12):1465-1473
pubmed: 28957540
Ann Intern Med. 2021 Apr;174(4):ITC49-ITC64
pubmed: 33844574
Clin Sci (Lond). 2019 Dec 20;133(24):2481-2498
pubmed: 31868216
Cureus. 2022 Aug 24;14(8):e28333
pubmed: 36168358
Nature. 1990 Dec 20-27;348(6303):732-5
pubmed: 2175397
Pulm Pharmacol Ther. 1999;12(5):303-12
pubmed: 10545286
Int J Mol Sci. 2021 Mar 27;22(7):
pubmed: 33801690
Br J Pharmacol. 2013 Jan;168(2):283-95
pubmed: 22118774
J Clin Invest. 2013 Jun;123(6):2643-53
pubmed: 23676500
Eur Respir J. 2018 Aug 30;52(2):
pubmed: 29976656
Am J Respir Crit Care Med. 2017 Feb 15;195(4):425-437
pubmed: 27627135
BMJ. 2018 Mar 14;360:j5492
pubmed: 29540357
Circulation. 2000 Nov 7;102(19):2434-40
pubmed: 11067800
PLoS One. 2013 Nov 27;8(11):e81309
pubmed: 24312288