Effects of Modified Glucosamine on the Chondrogenic Potential of Circulating Stem Cells under Experimental Inflammation.
CD73
IκBα
TNF receptors
TNFα
cartilage
glucosamine
inflammation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
20 Jun 2023
20 Jun 2023
Historique:
received:
24
12
2022
revised:
05
06
2023
accepted:
16
06
2023
medline:
29
6
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
epublish
Résumé
Glucosamine (GlcN) is a glycosaminoglycan (GAGs) constituent in connective tissues. It is naturally produced by our body or consumed from diets. In the last decade, in vitro and in vivo trials have demonstrated that the administration of GlcN or its derivates has a protective effect on cartilage when the balance between catabolic and anabolic processes is disrupted and cells are no longer able to fully compensate for the loss of collagen and proteoglycans. To date, these benefits are still controversial because the mechanism of action of GlcN is not yet well clarified. In this study, we have characterized the biological activities of an amino acid (AA) derivate of GlcN, called DCF001, in the growth and chondrogenic induction of circulating multipotent stem cells (CMCs) after priming with tumor necrosis factor-alpha (TNFα), a pleiotropic cytokine commonly expressed in chronic inflammatory joint diseases. In the present work, stem cells were isolated from the human peripheral blood of healthy donors. After priming with TNFα (10 ng/mL) for 3 h, cultures were treated for 24 h with DCF001 (1 μg/mL) dissolved in a proliferative (PM) or chondrogenic (CM) medium. Cell proliferation was analyzed using a Corning
Identifiants
pubmed: 37373540
pii: ijms241210397
doi: 10.3390/ijms241210397
pmc: PMC10299282
pii:
doi:
Substances chimiques
Glucosamine
N08U5BOQ1K
NF-KappaB Inhibitor alpha
139874-52-5
Tumor Necrosis Factor-alpha
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Polymers (Basel). 2021 Sep 09;13(18):
pubmed: 34577952
J Biol Chem. 2011 Nov 18;286(46):40133-41
pubmed: 21965673
Osteoarthritis Cartilage. 2020 May;28(5):708-718
pubmed: 31634583
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
Osteoarthritis Cartilage. 2007 Jan;15(1):59-68
pubmed: 16849037
J Zhejiang Univ Sci B. 2011 Nov;12(11):931-4
pubmed: 22042658
Cells Tissues Organs. 2001;169(3):285-94
pubmed: 11455125
Lancet. 2001 Jan 27;357(9252):251-6
pubmed: 11214126
BMC Res Notes. 2013 Mar 26;6:115
pubmed: 23531101
Arthritis Rheum. 2009 Mar;60(3):801-12
pubmed: 19248089
Osteoarthritis Cartilage. 1998 Nov;6(6):427-34
pubmed: 10343776
Org Biomol Chem. 2014 Oct 7;12(37):7238-49
pubmed: 25081868
Front Pharmacol. 2020 Jan 24;10:1591
pubmed: 32038258
Clin Immunol. 2018 Mar;188:67-73
pubmed: 29274390
Cells. 2022 Dec 13;11(24):
pubmed: 36552796
Osteoarthritis Cartilage. 1994 Mar;2(1):61-9
pubmed: 11548225
Am J Physiol Cell Physiol. 2008 Mar;294(3):C675-82
pubmed: 18234850
Diabetes Metab Res Rev. 2011 Jan;27(1):14-27
pubmed: 21218504
Sci Rep. 2019 Oct 30;9(1):15596
pubmed: 31666602
Genes Dev. 2003 Oct 1;17(19):2368-73
pubmed: 14522944
Acta Biomater. 2022 Sep 1;149:179-188
pubmed: 35779773
Pharmatherapeutica. 1981;2(8):504-8
pubmed: 7019929
Cell Death Differ. 2003 Jan;10(1):45-65
pubmed: 12655295
Ther Adv Musculoskelet Dis. 2020 Dec 26;12:1759720X20975927
pubmed: 33488785
Osteoarthritis Cartilage. 2010 Oct;18(10):1256-62
pubmed: 20691795
Cell Prolif. 2020 Jan;53(1):e12712
pubmed: 31730279
Biostat Bioinforma Biomath. 2013 Aug;3(3):71-85
pubmed: 25558171
Appl Microbiol Biotechnol. 2019 Oct;103(19):7883-7889
pubmed: 31440792
FEBS Lett. 2002 Jul 31;524(1-3):199-203
pubmed: 12135767
Int J Cell Biol. 2015;2015:834893
pubmed: 26448760
Front Immunol. 2018 Jul 20;9:1658
pubmed: 30079066
Arthritis Res Ther. 2014 Sep 26;16(5):441
pubmed: 25256035
Rheumatology (Oxford). 2002 May;41(5):484-9
pubmed: 12011369
Clin Exp Rheumatol. 2007 Nov-Dec;25(6):847-52
pubmed: 18173918
Eur Cell Mater. 2016 Jun 24;31:425-39
pubmed: 27341301
Arthritis Res Ther. 2010;12(1):R18
pubmed: 20113495
Free Radic Biol Med. 2014 Mar;68:234-46
pubmed: 24374373
Bone Res. 2019 Mar 6;7:8
pubmed: 30854241
Int J Pharm. 2013 Oct 15;455(1-2):365-73
pubmed: 23830943
Appl Microbiol Biotechnol. 2013 Jul;97(14):6149-58
pubmed: 23754704
Metab Eng. 2005 May;7(3):201-14
pubmed: 15885618
Curr Opin Rheumatol. 2011 Sep;23(5):471-8
pubmed: 21788902
Arthritis Res Ther. 2013 Jan 08;15(1):R5
pubmed: 23298463
Knee Surg Sports Traumatol Arthrosc. 2014 Jun;22(6):1249-59
pubmed: 24258020
Arthritis Res Ther. 2012 Jan 30;14(1):201
pubmed: 22293240
J Biol Chem. 2000 Feb 4;275(5):3687-92
pubmed: 10652367
J Clin Med. 2021 Apr 16;10(8):
pubmed: 33923501
Ortop Traumatol Rehabil. 2022 Dec 31;24(6):407-416
pubmed: 36734661
NPJ Syst Biol Appl. 2021 Dec 1;7(1):42
pubmed: 34853340
Stem Cell Res Ther. 2019 May 20;10(1):139
pubmed: 31109359
Life Sci. 2010 Mar 27;86(13-14):538-43
pubmed: 20188111
Biochem J. 1986 Jan 15;233(2):309-19
pubmed: 3006665
Front Bioeng Biotechnol. 2020 Jun 30;8:658
pubmed: 32714905
Int J Mol Sci. 2021 Jul 06;22(14):
pubmed: 34298867
PLoS One. 2016 Oct 24;11(10):e0165158
pubmed: 27776166
Arthritis Res. 2001;3(2):107-13
pubmed: 11178118
J Anim Sci. 2016 Aug;94(8):3294-3302
pubmed: 27695773
J Endocrinol. 2012 Sep;214(3):337-48
pubmed: 22685336
J Pathol. 2008 Jan;214(2):149-60
pubmed: 18161752
Front Cell Dev Biol. 2020 Oct 29;8:577572
pubmed: 33195216
Osteoarthritis Cartilage. 2017 Apr;25(4):589-599
pubmed: 27836674
Ann Rheum Dis. 2020 Oct;79(10):1261-1263
pubmed: 32554393
Stem Cells. 2016 Mar;34(3):781-90
pubmed: 26731338
J Biol Chem. 2010 Jun 11;285(24):18948-58
pubmed: 20404334
Osteoarthritis Cartilage. 2007 Jul;15(7):764-72
pubmed: 17353133
J Bone Joint Surg Am. 2013 Sep 18;95(18):1640-50
pubmed: 24048551
J Cell Biol. 1991 Sep;114(6):1307-19
pubmed: 1894696
Clin Exp Rheumatol. 2004 May-Jun;22(3):293-9
pubmed: 15144122
Curr Signal Transduct Ther. 2010;5(1):12-24
pubmed: 25484640
Food Chem Toxicol. 2005 Feb;43(2):187-201
pubmed: 15621331
Am J Physiol Endocrinol Metab. 2000 Jan;278(1):E103-12
pubmed: 10644543
Dev Biol. 1991 Dec;148(2):562-72
pubmed: 1743401
Matrix Biol. 1996 Jul;15(2):91-8
pubmed: 8837010
Aging Dis. 2021 Jun 1;12(3):886-901
pubmed: 34094649
Stem Cell Res Ther. 2020 Jul 16;11(1):281
pubmed: 32669116
PLoS One. 2015 May 15;10(5):e0126786
pubmed: 25978315
Front Pharmacol. 2022 Mar 17;13:820971
pubmed: 35370756
Front Genet. 2021 Sep 03;12:717535
pubmed: 34539746
Nanomedicine (Lond). 2016 Aug;11(15):1929-46
pubmed: 27246559
Ann Rheum Dis. 2010 Feb;69(2):443-9
pubmed: 19293161
EMBO J. 2008 May 7;27(9):1357-67
pubmed: 18401342
Int J Mol Med. 2018 Jul;42(1):61-70
pubmed: 29568900
Osteoarthritis Cartilage. 2010 Jan;18(1):5-11
pubmed: 19733270
Osteoarthritis Cartilage. 2007 Jun;15(6):646-55
pubmed: 17337215
Cells. 2021 Aug 10;10(8):
pubmed: 34440811
Arthritis Rheum. 1991 Sep;34(9):1125-32
pubmed: 1930331
Ann Transl Med. 2020 Apr;8(8):561
pubmed: 32775362
Biochem Pharmacol. 2020 Apr;174:113784
pubmed: 31884043
Front Oncol. 2019 Mar 05;9:116
pubmed: 30891426
J Orthop Surg Res. 2020 Apr 16;15(1):150
pubmed: 32299482
Stem Cells Dev. 2013 Nov 15;22(22):2975-89
pubmed: 23815613
Nat Commun. 2017 May 11;8:15019
pubmed: 28492224
Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9479-84
pubmed: 15194822
Ann Pharmacother. 1998 May;32(5):574-9
pubmed: 9606479
Front Bioeng Biotechnol. 2021 Dec 17;9:770655
pubmed: 34976967
Osteoarthritis Cartilage. 1994 Mar;2(1):51-9
pubmed: 11548224
Front Immunol. 2023 Feb 06;14:1074863
pubmed: 36814921
PLoS One. 2017 Jun 22;12(6):e0179270
pubmed: 28640861
J Med Chem. 2018 Dec 13;61(23):10834-10859
pubmed: 30412404
J Cell Biol. 1987 Apr;104(4):1077-84
pubmed: 3558480
Mar Drugs. 2010 Sep 15;8(9):2493-516
pubmed: 20948902
Org Biomol Chem. 2014 Nov 7;12(41):8325-35
pubmed: 25212512
Arthritis Res Ther. 2006;8(6):R173
pubmed: 17109745
Life Sci. 2016 May 1;152:21-9
pubmed: 27012765
JAMA. 2000 Mar 15;283(11):1469-75
pubmed: 10732937
Exp Cell Res. 1977 Aug;108(1):47-55
pubmed: 330178
Scientifica (Cairo). 2012 Jan 1;2012:
pubmed: 23350039
Orthop Surg. 2019 Aug;11(4):698-704
pubmed: 31282065
N Engl J Med. 2006 Feb 23;354(8):795-808
pubmed: 16495392
Stem Cells Dev. 2012 Aug 10;21(12):2160-9
pubmed: 22229819
J Biol Chem. 1997 Feb 21;272(8):4836-42
pubmed: 9030540
Adv Drug Deliv Rev. 2003 Nov 28;55(12):1531-46
pubmed: 14623400
Clin Ther. 1980;3(4):260-72
pubmed: 7023675
Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9469-74
pubmed: 23690607