Hydrogen Peroxide, Povidone-Iodine and Chlorhexidine Fail to Eradicate

antibiotic tolerance biofilm oxidative stress periprosthetic joint infection surgical infection

Journal

Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444

Informations de publication

Date de publication:
23 May 2023
Historique:
received: 21 02 2023
revised: 18 05 2023
accepted: 18 05 2023
medline: 28 6 2023
pubmed: 28 6 2023
entrez: 28 6 2023
Statut: epublish

Résumé

Hydrogen peroxide, povidone-iodine, and chlorhexidine are antiseptics that are commonly added to irrigants to either prevent or treat infection. There are little clinical data available that demonstrate efficacy of adding antiseptics to irrigants in the treatment of periprosthetic joint infection after biofilm establishment. The objective of the study was to assess the bactericidal activity of the antiseptics on

Identifiants

pubmed: 37374013
pii: life13061230
doi: 10.3390/life13061230
pmc: PMC10304975
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : NIAMS NIH HHS
ID : K08 AR071494
Pays : United States
Organisme : NIAMS NIH HHS
ID : R03AR077602
Pays : United States
Organisme : NIAMS NIH HHS
ID : NIAMS K08AR071494
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR000146
Pays : United States
Organisme : NCATS NIH HHS
ID : NCATS KL2TR000146
Pays : United States
Organisme : NIAMS NIH HHS
ID : R03 AR077602
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR082167
Pays : United States

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Auteurs

Dana M Parker (DM)

Arthritis and Arthroplasty Design Lab, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA.

John A Koch (JA)

Arthritis and Arthroplasty Design Lab, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA.

Charles G Gish (CG)

Arthritis and Arthroplasty Design Lab, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA.

Kimberly M Brothers (KM)

Arthritis and Arthroplasty Design Lab, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA.

William Li (W)

Arthritis and Arthroplasty Design Lab, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA.

Jessica Gilbertie (J)

Center for One Health Research, Edward Via College of Osteopathic Medicine, Blacksburg, VA 24060, USA.

Sarah E Rowe (SE)

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Brian P Conlon (BP)

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Venkata K C Byrapogu (VKC)

Arthritis and Arthroplasty Design Lab, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA.

Kenneth L Urish (KL)

Arthritis and Arthroplasty Design Lab, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261, USA.

Classifications MeSH