Profiling of Differentially Expressed MicroRNAs in Human Umbilical Vein Endothelial Cells Exposed to Hyperglycemia via RNA Sequencing.
RNA sequencing
apoptosis
diabetes
endothelial dysfunction
human umbilical-vein endothelial cells
hyperglycemia
microRNA
oxidative stress
Journal
Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444
Informations de publication
Date de publication:
31 May 2023
31 May 2023
Historique:
received:
15
04
2023
revised:
24
05
2023
accepted:
29
05
2023
medline:
28
6
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
epublish
Résumé
Hyperglycemia is the hallmark of diabetes mellitus that results in oxidative stress, apoptosis, and diabetic vascular endothelial dysfunction. An increasing number of microRNAs (miRNAs) have been found to be involved in the pathogenesis of diabetic vascular complications. However, there is a limited number of studies that characterize the miRNA profile of endothelial cells exposed to hyperglycemia. Therefore, this study aims to analyze the miRNA profile of human umbilical-vein endothelial cells (HUVECs) exposed to hyperglycemia. HUVECs were divided into two groups: the control (treated with 5.5 mM glucose) and hyperglycemia (treated with 33.3 mM glucose) groups. RNA sequencing identified 17 differentially expressed miRNAs between the groups (
Identifiants
pubmed: 37374078
pii: life13061296
doi: 10.3390/life13061296
pmc: PMC10304839
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Fundamental Research Grant Scheme, Ministry of Higher Education, Malaysia
ID : FRGS/1/2019/SKK08/UKM/02/8
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