Serum Neurofilaments in Motor Neuron Disease and Their Utility in Differentiating ALS, PMA and PLS.
amyotrophic lateral sclerosis
motor neuron disease
neurofilament heavy
neurofilament light
primary lateral sclerosis
progressive muscular atrophy
Journal
Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444
Informations de publication
Date de publication:
31 May 2023
31 May 2023
Historique:
received:
03
05
2023
revised:
25
05
2023
accepted:
29
05
2023
medline:
28
6
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
epublish
Résumé
Neurofilament levels are elevated in many neurodegenerative diseases and have shown promise as diagnostic and prognostic biomarkers in Amyotrophic Lateral Sclerosis (ALS), the most common form of Motor Neuron Disease (MND). This study assesses serum neurofilament light (NFL) and neurofilament heavy (NFH) chain concentrations in patients with ALS, other variants of motor neuron disease such as Progressive Muscular Atrophy (PMA) and Primary Lateral Sclerosis (PLS), and a range of other neurological diseases. It aims to evaluate the use of NFL and NFH to differentiate these conditions and for the prognosis of MND disease progression. NFL and NFH levels were quantified using electrochemiluminescence immunoassays (ECLIA). Both were elevated in 47 patients with MND compared to 34 patients with other neurological diseases and 33 healthy controls. NFL was able to differentiate patients with MND from the other groups with a Receiver Operating Characteristic (ROC) curve area under the curve (AUC) of 0.90 (
Identifiants
pubmed: 37374084
pii: life13061301
doi: 10.3390/life13061301
pmc: PMC10301889
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Guarantors of Brain
ID : Clinical research fellowship
Organisme : Association of British Neurologists
ID : Clinical Research Fellowship
Organisme : Irish Institute of Clinical Neuroscience
ID : Research Grant
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