Immunolocalization of Enzymes/Membrane Transporters Related to Bone Mineralization in the Metaphyses of the Long Bones of Parathyroid-Hormone-Administered Mice.
ENPP1
MEPE
PHEX
TNALP
mineralization
parathyroid hormone
Journal
Medicina (Kaunas, Lithuania)
ISSN: 1648-9144
Titre abrégé: Medicina (Kaunas)
Pays: Switzerland
ID NLM: 9425208
Informations de publication
Date de publication:
20 Jun 2023
20 Jun 2023
Historique:
received:
11
05
2023
revised:
15
06
2023
accepted:
16
06
2023
medline:
29
6
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
epublish
Résumé
The present study aimed to demonstrate the immunolocalization and/or gene expressions of the enzymes and membrane transporters involved in bone mineralization after the intermittent administration of parathyroid hormone (PTH). The study especially focused on TNALP, ENPP1, and PHOSPHO1, which are involved in matrix vesicle-mediated mineralization, as well as PHEX and the SIBLING family, which regulate mineralization deep inside bone. Six-week-old male mice were subcutaneously injected with 20 μg/kg/day of human PTH (1-34) two times per day (
Identifiants
pubmed: 37374382
pii: medicina59061179
doi: 10.3390/medicina59061179
pmc: PMC10303494
pii:
doi:
Substances chimiques
Parathyroid Hormone
0
PHOSPHO1 protein, mouse
EC 3.1.3.-
Phosphoric Monoester Hydrolases
EC 3.1.3.2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japanese Society for the Promotion of Science
ID : 22K0991
Organisme : Japanese Society for the Promotion of Science
ID : 21K16928
Organisme : Japanese Society for the Promotion of Science
ID : 21H03103
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