COVID-19 Outcomes and Diabetes Mellitus: A Comprehensive Multicenter Prospective Cohort Study.

COVID-19 DPP4 inhibitor SARS-CoV-2 diabetes mellitus dipeptidyl-peptidase IV inhibitors disease severity hypoglycemic agents in-hospital complications mortality type 2

Journal

Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893

Informations de publication

Date de publication:
27 May 2023
Historique:
received: 30 04 2023
revised: 17 05 2023
accepted: 24 05 2023
medline: 28 6 2023
pubmed: 28 6 2023
entrez: 28 6 2023
Statut: epublish

Résumé

The link between type 2 diabetes (T2D) and the severe outcomes of COVID-19 has raised concerns about the optimal management of patients with T2D. This study aimed to investigate the clinical characteristics and outcomes of T2D patients hospitalized with COVID-19 and explore the potential associations between chronic T2D treatments and adverse outcomes. This was a multicenter prospective cohort study of T2D patients hospitalized with COVID-19 in Greece during the third wave of the pandemic (February-June 2021). Among the 354 T2D patients included in this study, 63 (18.6%) died during hospitalization, and 16.4% required ICU admission. The use of DPP4 inhibitors for the chronic management of T2D was associated with an increased risk of in-hospital death (adjusted odds ratio (adj. OR) 2.639, 95% confidence interval (CI) 1.148-6.068,

Identifiants

pubmed: 37374918
pii: microorganisms11061416
doi: 10.3390/microorganisms11061416
pmc: PMC10300742
pii:
doi:

Types de publication

Journal Article

Langues

eng

Références

Diabetologia. 2021 Apr;64(4):778-794
pubmed: 33599800
Diabetes Care. 2023 Apr 1;46(4):890-897
pubmed: 36826982
J Diabetes Complications. 2022 Nov;36(11):108336
pubmed: 36228563
Cytokine Growth Factor Rev. 2020 Apr;52:34-44
pubmed: 31831339
J Diabetes Metab Disord. 2021 Mar 27;20(1):543-550
pubmed: 33816358
Front Cardiovasc Med. 2021 Dec 15;8:787761
pubmed: 34977193
JAMA Intern Med. 2021 Oct 1;181(10):1412-1414
pubmed: 34228043
JAMA. 2020 Apr 7;323(13):1239-1242
pubmed: 32091533
Arch Immunol Ther Exp (Warsz). 2021 Feb 2;69(1):1
pubmed: 33527308
Beijing Da Xue Xue Bao Yi Xue Ban. 2020 Jun 18;52(3):420-424
pubmed: 32541972
Ann Intensive Care. 2020 Feb 7;10(1):17
pubmed: 32034567
J Diabetes. 2023 Feb;15(2):86-96
pubmed: 36690377
Diabetes Ther. 2023 Feb;14(2):335-346
pubmed: 36574200
Diabetes Metab J. 2021 Mar;45(2):251-259
pubmed: 33752274
Diabetes Res Clin Pract. 2020 Aug;166:108347
pubmed: 32711003
Diabetes Care. 2021 Dec;44(12):2645-2655
pubmed: 34625431
Nutr Diabetes. 2021 Jun 23;11(1):21
pubmed: 34168110
Acta Diabetol. 2021 Feb;58(2):139-144
pubmed: 32583078
Diabetes Res Clin Pract. 2020 Aug;166:108331
pubmed: 32682810
Diabetes Metab Syndr. 2021 May-Jun;15(3):777-782
pubmed: 33838614
Biosci Rep. 2021 Feb 26;41(2):
pubmed: 33480978
J Clin Virol. 2020 Jun;127:104371
pubmed: 32315817
Diabetes Care. 2020 Jul;43(7):1382-1391
pubmed: 32409504
Int J Endocrinol Metab. 2021 Sep 15;19(4):e113220
pubmed: 35069750
Clin Res Cardiol. 2020 May;109(5):531-538
pubmed: 32161990
Annu Rev Med. 2022 Jan 27;73:129-147
pubmed: 34379444
Diabetes Res Clin Pract. 2020 Apr;162:108125
pubmed: 32224164
Arch Acad Emerg Med. 2020 Mar 24;8(1):e35
pubmed: 32232218
Diabetes Metab Syndr. 2020 May - Jun;14(3):211-212
pubmed: 32172175
Circ J. 2013;77(5):1337-44
pubmed: 23386232
Lancet Diabetes Endocrinol. 2021 May;9(5):293-303
pubmed: 33798464
JAMA. 2002 Nov 27;288(20):2579-88
pubmed: 12444865
J Diabetes. 2020 Dec;12(12):946-948
pubmed: 32909344
Nat Rev Endocrinol. 2021 Jan;17(1):11-30
pubmed: 33188364
Mol Med. 2008 Mar-Apr;14(3-4):222-31
pubmed: 18235842
Med Res Rev. 2019 Jan;39(1):404-422
pubmed: 29806214
Diabetes Care. 2021 Feb;44(2):526-532
pubmed: 33268335
J Clin Virol. 2020 Jul;128:104389
pubmed: 32387969
Diabetes Care. 2020 Jul;43(7):1408-1415
pubmed: 32430456
Therapie. 2020 Jul - Aug;75(4):381-384
pubmed: 32425250
Diabetes Metab Syndr. 2020 Sep - Oct;14(5):765-766
pubmed: 32512520
Metabolism. 2013 Mar;62(3):347-51
pubmed: 23062489
Diabetes Care. 2020 Dec;43(12):2999-3006
pubmed: 32994187
BMJ Open. 2021 Oct 25;11(10):e052777
pubmed: 34697120
Diabetes Res Clin Pract. 2020 Apr;162:108142
pubmed: 32278764
Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Dec;1867(12):159234
pubmed: 36185030
Diabetes Metab Syndr. 2020 Jul - Aug;14(4):395-403
pubmed: 32334395
Lancet Infect Dis. 2014 Feb;14(2):100-1
pubmed: 24457167
Medicine (Baltimore). 2020 Jul 02;99(27):e20913
pubmed: 32629686
Diabetes Metab. 2021 Mar;47(2):101213
pubmed: 33249199
Lancet Diabetes Endocrinol. 2022 Feb;10(2):95-97
pubmed: 34822751
Aging (Albany NY). 2020 Apr 8;12(7):6049-6057
pubmed: 32267833
MMWR Morb Mortal Wkly Rep. 2021 Nov 19;70(46):1613-1616
pubmed: 34793414
Ther Adv Endocrinol Metab. 2019 Sep 23;10:2042018819875406
pubmed: 31598211
Ann N Y Acad Sci. 2002 Jun;967:43-51
pubmed: 12079834
J Diabetes Complications. 2023 Feb;37(2):108391
pubmed: 36621213
Expert Rev Endocrinol Metab. 2023 Mar;18(2):167-179
pubmed: 36797835
Pathogens. 2023 Jan 25;12(2):
pubmed: 36839456
Emerg Microbes Infect. 2020 Dec;9(1):601-604
pubmed: 32178593
Cell Metab. 2020 Sep 1;32(3):498-499
pubmed: 32877692
Biomolecules. 2015 Mar 16;5(1):194-222
pubmed: 25786107
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Front Endocrinol (Lausanne). 2021 Mar 31;12:609470
pubmed: 33868163
Metab Syndr Relat Disord. 2020 May;18(4):173-175
pubmed: 32271125
J Diabetes Complications. 2021 Jan;35(1):107765
pubmed: 33187869
Diabetes Care. 2020 Oct;43(10):2339-2344
pubmed: 32769128
Lancet Diabetes Endocrinol. 2020 Oct;8(10):813-822
pubmed: 32798472
Clin Med Insights Endocrinol Diabetes. 2020 Mar 20;13:1179551420912972
pubmed: 32231442
Rev Endocr Metab Disord. 2021 Jun;22(2):275-296
pubmed: 33616801
Am J Med Sci. 2016 Feb;351(2):201-11
pubmed: 26897277
BMJ Open Diabetes Res Care. 2020 Apr;8(1):
pubmed: 32345580
Eur Heart J Cardiovasc Pharmacother. 2021 May 23;7(3):e48-e51
pubmed: 32766831
Clin Investig Arterioscler. 2021 May-Jun;33(3):151-157
pubmed: 33303218
J Endocrinol Invest. 2021 Jul;44(7):1379-1386
pubmed: 33512688
Exp Clin Endocrinol Diabetes. 2023 May;131(5):260-267
pubmed: 36693416
J Clin Virol. 2020 Jun;127:104354
pubmed: 32305882
Curr Diabetes Rev. 2020;16(5):442-449
pubmed: 31657690
Lancet Respir Med. 2020 May;8(5):475-481
pubmed: 32105632
J Gen Intern Med. 2022 Mar;37(4):870-877
pubmed: 34993873
Lancet Diabetes Endocrinol. 2020 Oct;8(10):823-833
pubmed: 32798471

Auteurs

Karolina Akinosoglou (K)

Department of Internal Medicine, Faculty of Medicine, University of Patras, University Hospital of Patras, 265 04 Patras, Greece.

Georgios Schinas (G)

Department of Internal Medicine, Faculty of Medicine, University of Patras, University Hospital of Patras, 265 04 Patras, Greece.

Evanthia Bletsa (E)

Department of Internal Medicine, General Hospital of Lamia, 351 00 Lamia, Greece.

Magdaline Bristianou (M)

Department of Internal Medicine, General Hospital of Lamia, 351 00 Lamia, Greece.

Leonidas Lanaras (L)

Department of Internal Medicine, General Hospital of Lamia, 351 00 Lamia, Greece.

Charalambos Michailides (C)

1st Department of Internal Medicine, General Hospital of Athens "G. Gennimatas", 115 27 Athens, Greece.

Theodoros Katsikas (T)

1st Department of Internal Medicine, General Hospital of Athens "G. Gennimatas", 115 27 Athens, Greece.

Fotios Barkas (F)

2nd Department of Internal Medicine, Faculty of Medicine, School of Health Sciences, University of Ioannina, 451 10 Ioannina, Greece.

Evangelos Liberopoulos (E)

2nd Department of Internal Medicine, Faculty of Medicine, School of Health Sciences, University of Ioannina, 451 10 Ioannina, Greece.

Vasileios Kotsis (V)

3rd Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, General Hospital of Thessaloniki "Papageorgiou", 564 29 Thessaloniki, Greece.

Konstantinos Tentolouris (K)

Department of Internal Medicine, General Hospital of Athens "Elpis", 115 22 Athens, Greece.

Pinelopi Grigoropoulou (P)

Department of Internal Medicine, General Hospital of Athens "Elpis", 115 22 Athens, Greece.

Archontoula Frangou (A)

Department of Internal Medicine, General Hospital of Athens "Elpis", 115 22 Athens, Greece.

Dimitrios Basoulis (D)

1st Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, 11527 Athens, Greece.

Zoi Alexiou (Z)

General Hospital of Eleusis "Thriasio", 196 00 Athens, Greece.

Mary Daganou (M)

Intensive Care Unit, General Hospital for Thoracic Diseases "Sotiria", 115 27 Athens, Greece.

Clementine Bostantzoglou (C)

Intensive Care Unit, General Hospital for Thoracic Diseases "Sotiria", 115 27 Athens, Greece.

Vasiliki Dimakopoulou (V)

Department of Internal Medicine, Faculty of Medicine, University of Patras, University Hospital of Patras, 265 04 Patras, Greece.

Antonia Koutsoukou (A)

1st University Pulmonology Clinic and ICU, Medical School, National and Kapodistrian University of Athens, General Hospital for Thoracic Diseases "Sotiria", 115 27 Athens, Greece.

Angelos Pefanis (A)

Department of Medicine and 1st Department of Infectious Diseases, General Hospital for Thoracic Diseases "Sotiria", 115 27 Athens, Greece.

Ioannis G Baraboutis (IG)

Department of Internal Medicine, "Pammakaristos" Hospital, 111 44 Athens, Greece.

Eleni Agelonidou (E)

Department of Internal Medicine, "Pammakaristos" Hospital, 111 44 Athens, Greece.

Nikolaos Tentolouris (N)

1st Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, 11527 Athens, Greece.

Classifications MeSH