Adenylosuccinic Acid: An Orphan Drug with Untapped Potential.
ADSSL1 myopathy
Duchenne muscular dystrophy
Nrf2 activation
adenylosuccinate
adenylosuccinic acid
immunometabolism
metabolic disease
purine metabolism
skeletal muscle
succinyl-AMP
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
31 May 2023
31 May 2023
Historique:
received:
09
05
2023
revised:
24
05
2023
accepted:
24
05
2023
medline:
28
6
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
epublish
Résumé
Adenylosuccinic acid (ASA) is an orphan drug that was once investigated for clinical application in Duchenne muscular dystrophy (DMD). Endogenous ASA participates in purine recycling and energy homeostasis but might also be crucial for averting inflammation and other forms of cellular stress during intense energy demand and maintaining tissue biomass and glucose disposal. This article documents the known biological functions of ASA and explores its potential application for the treatment of neuromuscular and other chronic diseases.
Identifiants
pubmed: 37375769
pii: ph16060822
doi: 10.3390/ph16060822
pmc: PMC10304260
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NICHD NIH HHS
ID : P50 HD105351
Pays : United States
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