Nafcillin-Loaded Photocrosslinkable Nanocomposite Hydrogels for Biomedical Applications.
drug delivery
hydrogel
nafcillin
nanocomposite
photocrosslinkable
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
24 May 2023
24 May 2023
Historique:
received:
28
04
2023
revised:
18
05
2023
accepted:
19
05
2023
medline:
28
6
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
epublish
Résumé
Skin infections are frequently treated via intravenous or oral administration of antibiotics, which can lead to serious adverse effects and may sometimes contribute to the proliferation of resistant bacterial strains. Skin represents a convenient pathway for delivering therapeutic compounds, ensured by the high number of blood vessels and amount of lymphatic fluids in the cutaneous tissues, which are systematically connected to the rest of the body. This study provides a novel, straightforward method to obtain nafcillin-loaded photocrosslinkable nanocomposite hydrogels and demonstrates their performance as drug carriers and antimicrobial efficacy against Gram-positive bacteria. The novel formulations obtained, based on polyvinylpyrrolidone, tri(ethylene glycol) divinyl ether crosslinker, hydrophilic bentonite nanoclay, and/or two types of photoactive (TiO
Identifiants
pubmed: 37376037
pii: pharmaceutics15061588
doi: 10.3390/pharmaceutics15061588
pmc: PMC10304380
pii:
doi:
Types de publication
Journal Article
Langues
eng
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