The Resistance to EGFR-TKIs in Non-Small Cell Lung Cancer: From Molecular Mechanisms to Clinical Application of New Therapeutic Strategies.
EGFR mutations
non-small cell lung cancer
resistance mechanisms
tyrosine kinase inhibitors
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
27 May 2023
27 May 2023
Historique:
received:
21
04
2023
revised:
13
05
2023
accepted:
24
05
2023
medline:
28
6
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
epublish
Résumé
Almost 17% of Western patients affected by non-small cell lung cancer (NSCLC) have an activating epidermal growth factor receptor (EGFR) gene mutation. Del19 and L858R are the most-common ones; they are positive predictive factors for EGFR tyrosine kinase inhibitors (TKIs). Currently, osimertinib, a third-generation TKI, is the standard first-line therapy for advanced NSCLC patients with common EGFR mutations. This drug is also administered as a second-line treatment for those patients with the T790M EGFR mutation and previously treated with first- (erlotinib, gefitinib) or second- (afatinib) generation TKIs. However, despite the high clinical efficacy, the prognosis remains severe due to intrinsic or acquired resistance to EGRF-TKIs. Various mechanisms of resistance have been reported including the activation of other signalling pathways, the development of secondary mutations, the alteration of the downstream pathways, and phenotypic transformation. However, further data are needed to achieve the goal of overcoming resistance to EGFR-TKIs, hence the necessity of discovering novel genetic targets and developing new-generation drugs. This review aimed to deepen the knowledge of intrinsic and acquired molecular mechanisms of resistance to EGFR-TKIs and the development of new therapeutic strategies to overcome TKIs' resistance.
Identifiants
pubmed: 37376053
pii: pharmaceutics15061604
doi: 10.3390/pharmaceutics15061604
pmc: PMC10302309
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
N Engl J Med. 2009 Sep 3;361(10):947-57
pubmed: 19692680
Clin Cancer Res. 2021 Mar 15;27(6):1604-1611
pubmed: 33376097
J Thorac Oncol. 2021 May;16(5):740-763
pubmed: 33338652
Ann Oncol. 2015 Oct;26(10):2073-8
pubmed: 26269204
Clin Cancer Res. 2015 Oct 15;21(20):4686-97
pubmed: 26124204
Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2070-5
pubmed: 18227510
Oncotarget. 2017 Mar 14;8(11):18609-18614
pubmed: 28061471
Int J Mol Sci. 2019 Mar 21;20(6):
pubmed: 30901844
Ann Oncol. 2019 Aug 1;30(8):1321-1328
pubmed: 31125062
Jpn J Clin Oncol. 2015 Jul;45(7):670-6
pubmed: 25877748
Klin Onkol. 2019 Fall;32(Supplementum 3):6-12
pubmed: 31627700
Cancers (Basel). 2023 Jan 20;15(3):
pubmed: 36765612
Lung Cancer. 2020 Aug;146:165-173
pubmed: 32540560
Cancer. 2020 Jan 15;126(2):373-380
pubmed: 31769875
Sci Transl Med. 2017 Nov 15;9(416):
pubmed: 29141884
Lung Cancer. 2021 Sep;159:18-26
pubmed: 34303276
Clin Cancer Res. 2022 Jun 23;:OF1-OF10
pubmed: 35735998
Lancet Oncol. 2019 Dec;20(12):1681-1690
pubmed: 31587882
Expert Rev Anticancer Ther. 2018 Oct;18(10):1021-1030
pubmed: 30079781
J Thorac Oncol. 2019 May;14(5):802-815
pubmed: 30831205
J Thorac Oncol. 2019 Nov;14(11):1995-2002
pubmed: 31377341
Clin Cancer Res. 2015 Sep 1;21(17):3913-23
pubmed: 25948633
JAMA Oncol. 2018 Aug 1;4(8):1112-1115
pubmed: 29327061
Lancet. 2016 Apr 9;387(10027):1540-1550
pubmed: 26712084
Sci Transl Med. 2011 Jul 6;3(90):90ra59
pubmed: 21734175
Front Oncol. 2020 Nov 03;10:590707
pubmed: 33224885
Nat Commun. 2021 Mar 19;12(1):1780
pubmed: 33741979
Cancer. 2021 May 1;127(9):1407-1416
pubmed: 33434335
Lancet Respir Med. 2019 May;7(5):387-401
pubmed: 30922878
Cancer Discov. 2018 Dec;8(12):1529-1539
pubmed: 30257958
Lung Cancer. 2017 Sep;111:84-87
pubmed: 28838405
J Clin Oncol. 2017 Dec 20;35(36):4027-4034
pubmed: 28968167
Lancet Respir Med. 2020 Nov;8(11):1132-1143
pubmed: 32479794
Cancer Lett. 2017 Jan 28;385:51-54
pubmed: 27840244
Lung Cancer. 2020 Feb;140:19-26
pubmed: 31841714
J Thorac Oncol. 2019 Oct;14(10):e220-e221
pubmed: 31558231
Lancet Oncol. 2017 Nov;18(11):1454-1466
pubmed: 28958502
J Thorac Oncol. 2018 Aug;13(8):1222-1226
pubmed: 29702285
Ann Oncol. 2014 Jan;25(1):126-31
pubmed: 24285021
J Clin Oncol. 2019 Feb 1;37(4):278-285
pubmed: 30550363
Cancer Discov. 2014 May;4(5):606-19
pubmed: 24535670
J Thorac Oncol. 2019 May;14(5):933-939
pubmed: 30763730
Target Oncol. 2019 Jun;14(3):335-342
pubmed: 31124059
Cancer Sci. 2018 Sep;109(9):2852-2862
pubmed: 29972716
J Thorac Oncol. 2019 Jun;14(6):e135-e136
pubmed: 31122569
Eur J Cancer. 2022 Sep;172:276-286
pubmed: 35810553
Cancer Cell. 2011 Jun 14;19(6):754-64
pubmed: 21665149
Pharmacol Res. 2021 May;167:105583
pubmed: 33775864
J Thorac Oncol. 2020 Aug;15(8):1369-1375
pubmed: 32353596
Cancer Discov. 2019 Jul;9(7):926-943
pubmed: 31092401
J Clin Oncol. 2010 Jan 10;28(2):357-60
pubmed: 19949011
Expert Rev Clin Pharmacol. 2017 Jan;10(1):31-38
pubmed: 27885838
J Clin Oncol. 2012 Jan 1;30(1):110-2
pubmed: 22067391
PLoS One. 2010 Nov 29;5(11):e14117
pubmed: 21152424
Ann Oncol. 2015 Sep;26(9):1877-1883
pubmed: 26141208
Ann Oncol. 2013 Jan;24(1):54-9
pubmed: 22967997
Expert Opin Pharmacother. 2020 Jun;21(9):1059-1069
pubmed: 32208985
ESMO Open. 2021 Dec;6(6):100319
pubmed: 34837746
Clin Cancer Res. 2013 Apr 15;19(8):2240-7
pubmed: 23470965
Ann Oncol. 1997 Dec;8(12):1197-206
pubmed: 9496384
Future Oncol. 2022 Feb;18(6):639-647
pubmed: 34911336
J Hematol Oncol. 2016 Apr 12;9:34
pubmed: 27071706
Ann Oncol. 2019 May 1;30(5):839-844
pubmed: 30847464
J Thorac Oncol. 2013 Jan;8(1):45-51
pubmed: 23242437
ESMO Open. 2016 May 11;1(3):e000060
pubmed: 27843613
Gene. 2006 Jan 17;366(1):2-16
pubmed: 16377102
Cancer Discov. 2021 Apr;11(4):874-899
pubmed: 33811122
Onco Targets Ther. 2018 Dec 18;12:51-56
pubmed: 30588029
Nat Commun. 2023 Feb 27;14(1):1071
pubmed: 36849516
Cell Commun Signal. 2023 Apr 11;21(1):71
pubmed: 37041601
Lancet Oncol. 2011 Feb;12(2):175-80
pubmed: 21277552
Nat Rev Cancer. 2019 Sep;19(9):495-509
pubmed: 31406302
Clin Cancer Res. 2019 Nov 15;25(22):6644-6652
pubmed: 31439584
J Thorac Oncol. 2018 Sep;13(9):1363-1372
pubmed: 29802888
J Clin Med. 2020 Apr 07;9(4):
pubmed: 32272775
N Engl J Med. 2018 Jan 11;378(2):113-125
pubmed: 29151359
Nature. 2009 Dec 24;462(7276):1070-4
pubmed: 20033049
Nat Cancer. 2021 Apr;2(4):377-391
pubmed: 35122001
Clin Cancer Res. 2021 Aug 1;27(15):4168-4176
pubmed: 34031056
Clin Cancer Res. 2018 Dec 15;24(24):6195-6203
pubmed: 30228210
Expert Opin Pharmacother. 2023 Jun;24(8):887-900
pubmed: 37038927
N Engl J Med. 2016 Nov 10;375(19):1823-1833
pubmed: 27718847
Cancers (Basel). 2022 Aug 20;14(16):
pubmed: 36011021
Cancer Sci. 2016 Sep;107(9):1179-86
pubmed: 27323238
Proc Natl Acad Sci U S A. 2006 May 16;103(20):7817-22
pubmed: 16672372
Clin Chest Med. 2020 Mar;41(1):1-24
pubmed: 32008623
Thorac Cancer. 2021 Mar;12(6):864-873
pubmed: 33522139
EBioMedicine. 2018 Mar;29:112-127
pubmed: 29433983
Curr Treat Options Oncol. 2020 Apr 18;21(4):33
pubmed: 32306194
Ann Oncol. 2019 Dec 1;30(12):1978-1984
pubmed: 31553438
Cancer Treat Rev. 2018 Apr;65:1-10
pubmed: 29477930
Int J Mol Sci. 2019 Aug 05;20(15):
pubmed: 31387256
J Med Chem. 2022 Jul 28;65(14):9662-9677
pubmed: 35838760
J Thorac Oncol. 2019 Feb;14(2):e27-e29
pubmed: 30683294
Lancet Oncol. 2011 Aug;12(8):735-42
pubmed: 21783417
N Engl J Med. 2020 Jan 2;382(1):41-50
pubmed: 31751012
Lung Cancer. 2020 Jul;145:1-9
pubmed: 32387812
Oncotarget. 2017 Jul 25;8(30):49671-49679
pubmed: 28572531
Clin Cancer Res. 2016 Oct 1;22(19):4837-4847
pubmed: 27252416
J Clin Oncol. 2016 Oct 1;34(28):3375-82
pubmed: 27354477
Lung Cancer. 2018 Oct;124:110-116
pubmed: 30268447
Cancer Sci. 2003 Jan;94(1):50-6
pubmed: 12708474
ESMO Open. 2021 Oct;6(5):100271
pubmed: 34543864
Clin Cancer Res. 2011 Mar 15;17(6):1616-22
pubmed: 21135146
Curr Opin Cell Biol. 2003 Dec;15(6):740-6
pubmed: 14644200
Future Oncol. 2019 Feb;15(6):637-652
pubmed: 30404555
Ann Oncol. 2020 Apr;31(4):507-516
pubmed: 32139298
Front Oncol. 2021 May 25;11:635007
pubmed: 34113560
J Thorac Oncol. 2018 Aug;13(8):1138-1145
pubmed: 29874546
Cell. 2004 Aug 6;118(3):277-9
pubmed: 15294153
Med Res Rev. 2018 Sep;38(5):1550-1581
pubmed: 29377179
J Thorac Oncol. 2017 Apr;12(4):612-623
pubmed: 28017789
Lancet Oncol. 2020 Mar;21(3):373-386
pubmed: 32027846
Lancet Oncol. 2019 Dec;20(12):1655-1669
pubmed: 31591063
Lancet Oncol. 2010 Feb;11(2):121-8
pubmed: 20022809
Mol Cancer. 2020 May 2;19(1):81
pubmed: 32359357
Ann Oncol. 2019 Jul 1;30(7):1104-1113
pubmed: 30977778
Lancet Respir Med. 2018 Feb;6(2):107-116
pubmed: 29249325
Lancet Oncol. 2015 Jul;16(7):763-74
pubmed: 26045340
Differentiation. 2007 Nov;75(9):788-99
pubmed: 17608727
J Thorac Oncol. 2018 Jul;13(7):968-977
pubmed: 29626621
Biochim Biophys Acta. 2010 Mar;1804(3):559-66
pubmed: 20026433
JCO Precis Oncol. 2018;2:
pubmed: 30957057
Cells. 2020 Dec 03;9(12):
pubmed: 33287368
JCO Precis Oncol. 2019 Mar 27;3:
pubmed: 32914023
Ann Oncol. 2015 Sep;26(9):1883-1889
pubmed: 26105600
Nat Cancer. 2022 Apr;3(4):402-417
pubmed: 35422503
Lung Cancer. 2016 Apr;94:46-53
pubmed: 26973206
Oncol Rep. 2007 Feb;17(2):319-23
pubmed: 17203167
Pathology. 2015 Jun;47(4):320-8
pubmed: 25938344
J Thorac Oncol. 2011 Nov;6(11):1895-901
pubmed: 21841502
J Clin Oncol. 2022 Mar 1;40(7):710-718
pubmed: 34843401
J Clin Invest. 2014 Jul;124(7):3003-15
pubmed: 24911146
J Clin Oncol. 2016 Mar 1;34(7):721-30
pubmed: 26729443
Lancet Oncol. 2014 Feb;15(2):213-22
pubmed: 24439929
Eur Rev Med Pharmacol Sci. 2021 Nov;25(22):6862-6873
pubmed: 34859861
Lung Cancer. 2021 Jan;151:20-24
pubmed: 33279874
J Thorac Oncol. 2017 Mar;12(3):567-572
pubmed: 27923714
Lancet Oncol. 2022 Sep;23(9):1167-1179
pubmed: 35908558
J Thorac Oncol. 2018 Sep;13(9):e169-e172
pubmed: 30166014
Cancer Chemother Pharmacol. 2010 Jul;66(2):381-8
pubmed: 19921194
J Thorac Oncol. 2017 Nov;12(11):1723-1727
pubmed: 28662863
Science. 2004 Jun 4;304(5676):1497-500
pubmed: 15118125
Nat Genet. 2012 Jul 01;44(8):852-60
pubmed: 22751098
J Thorac Oncol. 2017 Nov;12(11):1728-1732
pubmed: 28843359
Cancers (Basel). 2019 Jul 01;11(7):
pubmed: 31266248
Thorac Cancer. 2020 Sep;11(9):2389-2397
pubmed: 32677256
Lancet Oncol. 2015 Aug;16(8):990-8
pubmed: 26159065
ESMO Open. 2022 Feb;7(1):100395
pubmed: 35149428
J Thorac Oncol. 2018 Sep;13(9):1312-1323
pubmed: 29883838
JAMA Oncol. 2021 Dec 01;7(12):e214761
pubmed: 34647988
N Engl J Med. 2017 Feb 16;376(7):629-640
pubmed: 27959700
Clin Cancer Res. 2008 May 15;14(10):2895-9
pubmed: 18483355
Cancer Res. 2011 Jul 1;71(13):4494-505
pubmed: 21555370
Cancer Discov. 2014 Sep;4(9):1036-45
pubmed: 25074459
Clin Cancer Res. 2005 Dec 15;11(24 Pt 1):8686-98
pubmed: 16361555
Nat Commun. 2017 Mar 13;8:14768
pubmed: 28287083
Cancer Discov. 2011 Sep;1(4):352-65
pubmed: 22145099
Ann Transl Med. 2022 Jun;10(12):719
pubmed: 35845537
Clin Cancer Res. 2014 Apr 1;20(7):2001-10
pubmed: 24493829
J Cell Biochem. 2019 Jan;120(1):756-767
pubmed: 30145802
Lancet Respir Med. 2017 May;5(5):435-444
pubmed: 28408243
Cancers (Basel). 2021 Sep 30;13(19):
pubmed: 34638411
Clin Cancer Res. 2019 Jun 1;25(11):3341-3351
pubmed: 30796031
EMBO Mol Med. 2017 Feb;9(2):238-250
pubmed: 28003335
Oncotarget. 2017 Jul 25;8(30):50209-50220
pubmed: 28430586
EMBO Mol Med. 2018 Jun;10(6):
pubmed: 29848757
Nat Med. 2016 Mar;22(3):262-9
pubmed: 26828195
Cancer Res. 2015 Jun 15;75(12):2489-500
pubmed: 25870145
Clin Cancer Res. 2020 Jun 1;26(11):2654-2663
pubmed: 31911548
J Clin Invest. 2009 Oct;119(10):3000-10
pubmed: 19759520
J Clin Oncol. 2020 Jun 18;:JCO1903123
pubmed: 32552277
Nature. 2016 May 25;534(7605):129-32
pubmed: 27251290
Eur J Cancer. 2021 May;149:14-22
pubmed: 33813328
Sci Transl Med. 2011 Mar 23;3(75):75ra26
pubmed: 21430269
Lung Cancer. 2018 Jan;115:21-27
pubmed: 29290257
Expert Rev Anticancer Ther. 2020 Aug;20(8):647-661
pubmed: 32580596
Cancers (Basel). 2020 Dec 22;13(1):
pubmed: 33374971
Clin Lung Cancer. 2014 Jan;15(1):1-6
pubmed: 24176733
Cancer. 2020 Jun 1;126(11):2704-2712
pubmed: 32154925
Drugs. 2021 Feb;81(2):257-266
pubmed: 33331989
J Thorac Oncol. 2015 Dec;10(12):1713-9
pubmed: 26334752
J Thorac Oncol. 2019 May;14(5):e85-e88
pubmed: 30711650
J Thorac Oncol. 2017 Jan;12(1):15-26
pubmed: 27794501
J Clin Oncol. 2020 Jan 10;38(2):115-123
pubmed: 31682542
Mol Cancer Ther. 2020 Nov;19(11):2288-2297
pubmed: 32943545
Cancer Discov. 2012 Oct;2(10):922-33
pubmed: 22956644
N Engl J Med. 2004 May 20;350(21):2129-39
pubmed: 15118073
N Engl J Med. 2020 Oct 29;383(18):1711-1723
pubmed: 32955177
Transl Lung Cancer Res. 2015 Feb;4(1):36-54
pubmed: 25806345
Cancers (Basel). 2022 Apr 12;14(8):
pubmed: 35454838
J Thorac Oncol. 2017 Jul;12(7):e85-e88
pubmed: 28274743
Nat Genet. 2017 Dec;49(12):1693-1704
pubmed: 29106415
PLoS One. 2016 Mar 04;11(3):e0149370
pubmed: 26943330
Lung Cancer. 2017 Jun;108:228-231
pubmed: 28625641
Lung Cancer. 2021 Jan;151:69-75
pubmed: 33248711
Clin Lung Cancer. 2021 Jul;22(4):253-259
pubmed: 33582070
Semin Cancer Biol. 2020 Apr;61:167-179
pubmed: 31562956
Cancer Epidemiol Biomarkers Prev. 2019 Oct;28(10):1563-1579
pubmed: 31575553
J Clin Oncol. 2022 Nov 1;40(31):3587-3592
pubmed: 35960896
Lancet Oncol. 2015 Feb;16(2):141-51
pubmed: 25589191
Clin Cancer Res. 2017 May 1;23(9):2195-2202
pubmed: 27780855
J Cancer Res Clin Oncol. 2020 Sep;146(9):2329-2338
pubmed: 32596787
Clin Cancer Res. 2015 Feb 15;21(4):907-15
pubmed: 25492085
Acta Biomater. 2021 Jul 15;129:258-268
pubmed: 34048974
Ann Oncol. 2017 Jul 01;28(7):1532-1539
pubmed: 28407039
Clin Cancer Res. 2018 Jul 1;24(13):3097-3107
pubmed: 29506987
Cancer Med. 2021 Dec;10(23):8328-8337
pubmed: 34612594
Expert Opin Investig Drugs. 2022 Jul;31(7):747-757
pubmed: 35657653
Ann Oncol. 2017 Nov 01;28(11):2715-2724
pubmed: 28945865
Lancet Oncol. 2012 Mar;13(3):239-46
pubmed: 22285168
Ann Oncol. 2017 Oct 01;28(10):2443-2450
pubmed: 28945850
J Thorac Oncol. 2019 Dec;14(12):e274-e275
pubmed: 31757379
Cancer Res. 2006 Oct 15;66(20):10100-11
pubmed: 17047074
J Clin Oncol. 2011 Jul 20;29(21):2866-74
pubmed: 21670455
Front Oncol. 2021 Apr 13;11:598265
pubmed: 33928022
Clin Cancer Res. 2015 Sep 1;21(17):3924-33
pubmed: 25964297
JAMA Oncol. 2018 Nov 1;4(11):1527-1534
pubmed: 30073261
Clin Cancer Res. 2016 May 1;22(9):2139-45
pubmed: 26667485
J Clin Oncol. 2018 Nov 1;36(31):3101-3109
pubmed: 30156984