COVID-19 Impact on DTP Vaccination Trends in Africa: A Joinpoint Regression Analysis.
Africa
COVID-19
DTP vaccine
healthcare system
joinpoint regression
vaccination rates
vaccine coverage
Journal
Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355
Informations de publication
Date de publication:
15 Jun 2023
15 Jun 2023
Historique:
received:
30
04
2023
revised:
24
05
2023
accepted:
09
06
2023
medline:
28
6
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
epublish
Résumé
Deaths due to vaccine-preventable diseases are one of the leading causes of death among African children. Vaccine coverage is an essential measure to decrease infant mortality. The COVID-19 pandemic has affected the healthcare system and may have disrupted vaccine coverage. DTP third doses (DTP3) Vaccine Coverage was extracted from UNICEF databases from 2012 to 2021 (the last available date). Joinpoint regression was performed to detect the point where the trend changed. The annual percentage change (APC) with 95% confidence intervals (95% CI) was calculated for Africa and the regions. We compared DTP3 vaccination coverage in 2019-2021 in each country using the Chi-square test. During the whole period, the vaccine coverage in Africa increased with an Annual Percent change of 1.2% (IC 95% 0.9-1.5): We detected one joinpoint in 2019. In 2019-2021, there was a decrease in DTP3 coverage with an APC of -3.5 (95% -6.0; -0,9). ( COVID-19 has disrupted vaccine coverage, decreasing it all over Africa.
Sections du résumé
BACKGROUND
BACKGROUND
Deaths due to vaccine-preventable diseases are one of the leading causes of death among African children. Vaccine coverage is an essential measure to decrease infant mortality. The COVID-19 pandemic has affected the healthcare system and may have disrupted vaccine coverage.
METHODS
METHODS
DTP third doses (DTP3) Vaccine Coverage was extracted from UNICEF databases from 2012 to 2021 (the last available date). Joinpoint regression was performed to detect the point where the trend changed. The annual percentage change (APC) with 95% confidence intervals (95% CI) was calculated for Africa and the regions. We compared DTP3 vaccination coverage in 2019-2021 in each country using the Chi-square test.
RESULT
RESULTS
During the whole period, the vaccine coverage in Africa increased with an Annual Percent change of 1.2% (IC 95% 0.9-1.5): We detected one joinpoint in 2019. In 2019-2021, there was a decrease in DTP3 coverage with an APC of -3.5 (95% -6.0; -0,9). (
CONCLUSIONS
CONCLUSIONS
COVID-19 has disrupted vaccine coverage, decreasing it all over Africa.
Identifiants
pubmed: 37376492
pii: vaccines11061103
doi: 10.3390/vaccines11061103
pmc: PMC10305165
pii:
doi:
Types de publication
Journal Article
Langues
eng
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Curr Med Res Opin. 2021 Dec;37(12):2077-2087
pubmed: 34538163
Vaccines (Basel). 2023 Jan 15;11(1):
pubmed: 36680028
Vaccines (Basel). 2020 Oct 03;8(4):
pubmed: 33022916
Hum Vaccin Immunother. 2022 Dec 30;18(7):2145821
pubmed: 36459433
Stat Med. 2000 Feb 15;19(3):335-51
pubmed: 10649300
Open Forum Infect Dis. 2023 Mar 10;10(4):ofad136
pubmed: 37035496
Vaccines (Basel). 2023 Mar 14;11(3):
pubmed: 36992229
MMWR Morb Mortal Wkly Rep. 2021 Jun 11;70(23):840-845
pubmed: 34111058
Lancet. 2021 Aug 7;398(10299):522-534
pubmed: 34273292
Hum Vaccin Immunother. 2023 Dec 31;19(1):2202125
pubmed: 37144686
BMC Psychiatry. 2023 Jan 7;23(1):15
pubmed: 36611145
Hum Vaccin Immunother. 2022 Nov 30;18(5):2076524
pubmed: 35709342
Lancet Reg Health Am. 2023 Apr 06;21:100488
pubmed: 37096193
Innovation (Camb). 2021 May 05;2(2):100113
pubmed: 34557762
MMWR Morb Mortal Wkly Rep. 2022 Nov 04;71(44):1396-1400
pubmed: 36327156
PLoS Med. 2013;10(5):e1001404
pubmed: 23667334
Trop Med Int Health. 2010 Jan;15(1):140-7
pubmed: 19930140
Vaccines (Basel). 2023 Apr 13;11(4):
pubmed: 37112750
Health Sci Rep. 2023 Apr 20;6(4):e1198
pubmed: 37091357
J Community Health. 2022 Feb;47(1):39-52
pubmed: 34297272
Hum Vaccin Immunother. 2022 Dec 31;18(1):2007707
pubmed: 34920686
Int J Environ Res Public Health. 2021 Jan 22;18(3):
pubmed: 33499422
Lancet. 2009 May 2;373(9674):1543-9
pubmed: 19303633
Hum Vaccin Immunother. 2022 Dec 31;18(1):2036048
pubmed: 35239460
Front Pediatr. 2023 Mar 27;11:1054335
pubmed: 37051437
Vaccines (Basel). 2023 Apr 17;11(4):
pubmed: 37112771
Euro Surveill. 2020 May;25(19):
pubmed: 32431288
Environ Res. 2015 Oct;142:319-27
pubmed: 26188633
Vaccine. 2021 Jan 29;39(5):780-785
pubmed: 33414050
Hum Vaccin Immunother. 2018;14(10):2365-2372
pubmed: 29630441
PLoS One. 2012;7(5):e37905
pubmed: 22662247
PLoS One. 2022 May 10;17(5):e0268106
pubmed: 35536838
BMJ. 2023 Mar 21;380:627
pubmed: 36944436
MMWR Morb Mortal Wkly Rep. 2020 May 15;69(19):591-593
pubmed: 32407298
Hum Vaccin Immunother. 2015;11(11):2637-9
pubmed: 26365693
MMWR Morb Mortal Wkly Rep. 2021 Oct 29;70(43):1495-1500
pubmed: 34710074
Int J Environ Res Public Health. 2022 Oct 12;19(20):
pubmed: 36293727
Infect Dis Ther. 2021 Sep;10(3):1097-1113
pubmed: 33881713
Vacunas. 2020 Jul-Dec;21(2):129-135
pubmed: 32837461
Hum Vaccin Immunother. 2021 Jul 3;17(7):2326-2335
pubmed: 33760689