Significant Broad-Spectrum Antiviral Activity of Bi121 against Different Variants of SARS-CoV-2.


Journal

Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722

Informations de publication

Date de publication:
31 05 2023
Historique:
received: 20 04 2023
revised: 12 05 2023
accepted: 24 05 2023
medline: 29 6 2023
pubmed: 28 6 2023
entrez: 28 6 2023
Statut: epublish

Résumé

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has so far infected 762 million people with over 6.9 million deaths worldwide. Broad-spectrum viral inhibitors that block the initial stages of infection by reducing virus binding and proliferation, thereby reducing disease severities, are still an unmet global medical need. We studied Bi121, which is a standardized polyphenolic-rich compound isolated from

Identifiants

pubmed: 37376598
pii: v15061299
doi: 10.3390/v15061299
pmc: PMC10305169
pii:
doi:

Substances chimiques

Antiviral Agents 0
Spike Glycoprotein, Coronavirus 0
spike protein, SARS-CoV-2 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Bobban Subhadra (B)

Biom Pharmaceutical Corporation, 2203 Industrial Blvd, Sarasota, FL 34234, USA.

Ragini Agrawal (R)

Department of Microbiology and Cell Biology, Center for Infectious Disease Research, Indian Institute of Science (IISc), CV Raman Ave., Bengaluru 560012, India.

Virender Kumar Pal (VK)

Department of Microbiology and Cell Biology, Center for Infectious Disease Research, Indian Institute of Science (IISc), CV Raman Ave., Bengaluru 560012, India.

Agnes-Laurence Chenine (AL)

Integrated BioTherapeutics Inc., 4 Research Court, Suite 300, Rockville, MD 20850, USA.

Jeffy George Mattathil (JG)

Integrated BioTherapeutics Inc., 4 Research Court, Suite 300, Rockville, MD 20850, USA.

Amit Singh (A)

Department of Microbiology and Cell Biology, Center for Infectious Disease Research, Indian Institute of Science (IISc), CV Raman Ave., Bengaluru 560012, India.

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Classifications MeSH