Maternal Th17 Profile after Zika Virus Infection Is Involved in Congenital Zika Syndrome Development in Children.
disease infection
interleukin-17
microcephaly
vertical transmission
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
04 06 2023
04 06 2023
Historique:
received:
04
05
2023
revised:
31
05
2023
accepted:
02
06
2023
medline:
29
6
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
epublish
Résumé
Brazil is one of the countries that experienced an epidemic of microcephaly and other congenital manifestations related to maternal Zika virus infection which can result in Congenital Zika Syndrome (CZS). Since the Zika virus can modulate the immune system, studying mothers' and children's immune profiles become essential to better understanding CZS development. Therefore, we investigated the lymphocyte population profile of children who developed CZS and their mothers' immune response in this study. The study groups were formed from the Plaque Reduction Neutralization Test (PRNT) (CZS+ group) result. To evaluate the lymphocyte population profile, we performed phenotyping of peripheral lymphocytes and quantification of serum cytokine levels. The immunophenotyping and cytokine profile was correlated between CSZ+ children and their mothers. Both groups exhibited increased interleukin-17 levels and a reduction in the subpopulation of CD4+ T lymphocytes. In contrast, the maternal group showed a reduction in the population of B lymphocytes. Thus, the development of CZS is related to the presence of an inflammatory immune profile in children and their mothers characterized by Th17 activation.
Identifiants
pubmed: 37376620
pii: v15061320
doi: 10.3390/v15061320
pmc: PMC10301288
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Ann Neurol. 2017 Jan;81(1):152-156
pubmed: 27977881
J Neuroinflammation. 2012 Apr 30;9:83
pubmed: 22546005
Cells. 2019 Aug 03;8(8):
pubmed: 31382545
Front Immunol. 2021 Nov 25;12:764746
pubmed: 34899713
N Engl J Med. 2016 May 19;374(20):1981-7
pubmed: 27074377
Viruses. 2021 Jan 08;13(1):
pubmed: 33430059
JAMA Neurol. 2019 Feb 1;76(2):203-210
pubmed: 30452526
Rev Inst Med Trop Sao Paulo. 2020;62:e56
pubmed: 32844907
Mem Inst Oswaldo Cruz. 2016 May;111(5):287-93
pubmed: 27143490
Immunity. 2018 Sep 18;49(3):397-412
pubmed: 30231982
Radiology. 2017 Dec;285(3):744-761
pubmed: 29155634
PLoS Negl Trop Dis. 2017 Feb 23;11(2):e0005363
pubmed: 28231241
Science. 2016 Feb 26;351(6276):933-9
pubmed: 26822608
Sci Rep. 2018 Jan 8;8(1):1
pubmed: 29311619
Cell. 2019 Aug 22;178(5):1176-1188.e15
pubmed: 31442406
Clin Infect Dis. 2017 Apr 01;64(7):914-920
pubmed: 28362944
J Vis Exp. 2014 Nov 04;(93):e52065
pubmed: 25407402
Epidemiol Serv Saude. 2016 Oct-Dec;25(4):683-690
pubmed: 27869981
Mem Inst Oswaldo Cruz. 2015 Jun;110(4):569-72
pubmed: 26061233
PLoS Pathog. 2020 Dec 10;16(12):e1008689
pubmed: 33301527
Science. 2016 Apr 15;352(6283):345-349
pubmed: 27013429
Curr Opin Virol. 2016 Jun;18:76-81
pubmed: 27179929
Front Immunol. 2021 Feb 12;12:610456
pubmed: 33679748
Viruses. 2020 Oct 31;12(11):
pubmed: 33142747
Clin Sci (Lond). 2012 Feb;122(4):143-59
pubmed: 22029668
J Neurosci. 2007 Oct 3;27(40):10695-702
pubmed: 17913903
Lancet. 2016 Aug 27;388(10047):891-7
pubmed: 27372398
Lancet. 2016 May 21;387(10033):2125-2132
pubmed: 26993883
Sci Immunol. 2021 Feb 23;6(56):
pubmed: 33622974
Sci Immunol. 2020 Aug 7;5(50):
pubmed: 32769171
Hepatol Commun. 2019 Apr 16;3(6):795-811
pubmed: 31168514
JAMA Pediatr. 2017 Mar 1;171(3):288-295
pubmed: 27812690
PLoS Pathog. 2016 Nov 17;12(11):e1006004
pubmed: 27855206
Emerg Infect Dis. 2016 Nov;22(11):1953-1956
pubmed: 27767931
Lancet. 2017 Nov 4;390(10107):2099-2109
pubmed: 28647173
JAMA Neurol. 2016 Dec 01;73(12):1407-1416
pubmed: 27695855
N Engl J Med. 2016 Dec 15;375(24):2321-2334
pubmed: 26943629
Viruses. 2023 Jan 13;15(1):
pubmed: 36680261
Biochem Biophys Res Commun. 2017 Oct 28;492(4):597-602
pubmed: 28153732
J Inflamm Res. 2021 Feb 12;14:355-365
pubmed: 33603435
MMWR Morb Mortal Wkly Rep. 2016 Dec 02;65(47):1343-1348
pubmed: 27906905
Front Immunol. 2020 Sep 30;11:572567
pubmed: 33101294
Mem Inst Oswaldo Cruz. 2018 May 14;113(6):e170542
pubmed: 29768624
Cell Stem Cell. 2016 Nov 3;19(5):672
pubmed: 27814481
Nat Microbiol. 2017 Nov;2(11):1558-1570
pubmed: 28827581
Nature. 2016 May 11;534(7606):267-71
pubmed: 27279226
Open Forum Infect Dis. 2018 Apr 07;5(4):ofy073
pubmed: 29732381
Int J Environ Res Public Health. 2018 Sep 13;15(9):
pubmed: 30216976
Dev Neurobiol. 2012 Oct;72(10):1272-6
pubmed: 22488761
MMWR Morb Mortal Wkly Rep. 2018 Aug 10;67(31):858-867
pubmed: 30091967