Shades of gray in human white matter.
NADPH-d
subcortical
subplate
white matter neurons
Journal
The Journal of comparative neurology
ISSN: 1096-9861
Titre abrégé: J Comp Neurol
Pays: United States
ID NLM: 0406041
Informations de publication
Date de publication:
27 Jun 2023
27 Jun 2023
Historique:
revised:
22
05
2023
received:
20
02
2023
accepted:
31
05
2023
pubmed:
28
6
2023
medline:
28
6
2023
entrez:
28
6
2023
Statut:
aheadofprint
Résumé
Anatomists have long expressed interest in neurons of the white matter, which is by definition supposed to be free of neurons. Hypotheses regarding their biochemical signature and physiological function are mainly derived from animal models. Here, we investigated 15 whole-brain human postmortem specimens, including cognitively normal cases and those with pathologic Alzheimer's disease (AD). Quantitative and qualitative methods were used to investigate differences in neuronal size and density, and the relationship between neuronal processes and vasculature. Double staining was used to evaluate colocalization of neurochemicals. Two topographically distinct populations of neurons emerged: one appearing to arise from developmental subplate neurons and the other embedded within deep, subcortical white matter. Both populations appeared to be neurochemically heterogeneous, showing positive reactivity to acetylcholinesterase (AChE) [but not choline acetyltransferase (ChAT)], neuronal nuclei (NeuN), nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d), microtubule-associated protein 2 (MAP-2), somatostatin (SOM), nonphosphorylated neurofilament protein (SMI-32), and calcium-binding proteins calbindin-D
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIA NIH HHS
ID : F31AG07631
Pays : United States
Organisme : NIA NIH HHS
ID : P30AG072977
Pays : United States
Organisme : NIA NIH HHS
ID : R01AG062566
Pays : United States
Organisme : NINDS NIH HHS
ID : T32NS047987
Pays : United States
Organisme : NIA NIH HHS
ID : F31AG07631
Pays : United States
Organisme : NIA NIH HHS
ID : P30AG072977
Pays : United States
Organisme : NIA NIH HHS
ID : R01AG062566
Pays : United States
Organisme : NINDS NIH HHS
ID : T32NS047987
Pays : United States
Informations de copyright
© 2023 The Authors. The Journal of Comparative Neurology published by Wiley Periodicals LLC.
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