Sleep spindles across youth affected by schizophrenia or anti-

anti-NMDAR encephalitis psychosis schizophrenia sleep EEG sleep spindles thalamocortical network

Journal

Frontiers in psychiatry
ISSN: 1664-0640
Titre abrégé: Front Psychiatry
Pays: Switzerland
ID NLM: 101545006

Informations de publication

Date de publication:
2023
Historique:
received: 27 09 2022
accepted: 19 05 2023
medline: 28 6 2023
pubmed: 28 6 2023
entrez: 28 6 2023
Statut: epublish

Résumé

Sleep disturbances are intertwined with the progression and pathophysiology of psychotic symptoms in schizophrenia. Reductions in sleep spindles, a major electrophysiological oscillation during non-rapid eye movement sleep, have been identified in patients with schizophrenia as a potential biomarker representing the impaired integrity of the thalamocortical network. Altered glutamatergic neurotransmission within this network via a hypofunction of the Sleep EEG data of patients with COS ( Central sleep spindle density, maximum amplitude, and sigma power were reduced when comparing all patients with psychosis to all HC. Between patient group comparisons showed no differences in central spindle density but lower central maximum amplitude and sigma power in patients with COS compared to patients with EOS or NMDARE. Assessing the topography of spindle density, it was significantly reduced over 15/17 electrodes in COS, 3/17 in EOS, and 0/5 in NMDARE compared to HC. In the pooled sample of COS and EOS, a longer duration of illness was associated with lower central sigma power. Patients with COS demonstrated more pronounced impairments of sleep spindles compared to patients with EOS and NMDARE. In this sample, there is no strong evidence that changes in NMDAR activity are related to spindle deficits.

Sections du résumé

Background UNASSIGNED
Sleep disturbances are intertwined with the progression and pathophysiology of psychotic symptoms in schizophrenia. Reductions in sleep spindles, a major electrophysiological oscillation during non-rapid eye movement sleep, have been identified in patients with schizophrenia as a potential biomarker representing the impaired integrity of the thalamocortical network. Altered glutamatergic neurotransmission within this network via a hypofunction of the
Methods UNASSIGNED
Sleep EEG data of patients with COS (
Results UNASSIGNED
Central sleep spindle density, maximum amplitude, and sigma power were reduced when comparing all patients with psychosis to all HC. Between patient group comparisons showed no differences in central spindle density but lower central maximum amplitude and sigma power in patients with COS compared to patients with EOS or NMDARE. Assessing the topography of spindle density, it was significantly reduced over 15/17 electrodes in COS, 3/17 in EOS, and 0/5 in NMDARE compared to HC. In the pooled sample of COS and EOS, a longer duration of illness was associated with lower central sigma power.
Conclusions UNASSIGNED
Patients with COS demonstrated more pronounced impairments of sleep spindles compared to patients with EOS and NMDARE. In this sample, there is no strong evidence that changes in NMDAR activity are related to spindle deficits.

Identifiants

DOI: 10.3389/fpsyt.2023.1055459 PMID: 37377467 PMC: PMC10292628
pubmed: 37377467
doi: 10.3389/fpsyt.2023.1055459
pmc: PMC10292628
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1055459

Informations de copyright

Copyright © 2023 Dimitriades, Markovic, Gefferie, Buckley, Driver, Rapoport, Nosadini, Rostasy, Sartori, Suppiej, Kurth, Franscini, Walitza, Huber, Tarokh, Bölsterli and Gerstenberg.

Déclaration de conflit d'intérêts

In the past five years, SW has received royalties from Thieme Hogrefe, Kohlhammer, Springer, and Beltz, and her work was supported by the Swiss National Science Foundation (SNF), diff. EU FP7s, Bfarm Germany, ZInEP, Hartmann Müller, Olga Mayenfisch, Gertrud Thalmann, Vontobel, Unicentia, and Erika Schwarz Funds. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Références

Acta Psychiatr Scand. 2009 Nov;120(5):345-54
pubmed: 19807715
Front Hum Neurosci. 2014 Oct 07;8:762
pubmed: 25339881
Nat Sci Sleep. 2017 Sep 21;9:227-239
pubmed: 29033618
J Neurosci. 2018 Oct 24;38(43):9275-9285
pubmed: 30249805
Am J Psychiatry. 2010 Nov;167(11):1339-48
pubmed: 20843876
Arch Gen Psychiatry. 2010 Mar;67(3):241-51
pubmed: 20194824
Schizophr Res. 2015 May;164(1-3):15-20
pubmed: 25818627
Schizophr Bull. 2012 Sep;38(5):920-6
pubmed: 22987850
Neuroimage. 2021 Oct 1;239:118281
pubmed: 34147627
Neurosci Biobehav Rev. 2019 Feb;97:112-137
pubmed: 30312626
Schizophr Res. 2020 Jul;221:20-28
pubmed: 31924372
Schizophr Res. 2020 Jul;221:29-36
pubmed: 31753592
Schizophr Res. 2015 Oct;168(1-2):589-90
pubmed: 26285830
Schizophr Res. 2020 Sep;223:327-336
pubmed: 32980206
Physiol Rev. 2020 Apr 1;100(2):805-868
pubmed: 31804897
Schizophr Res. 2020 Jul;221:63-70
pubmed: 32014359
J Neurophysiol. 1987 Jan;57(1):260-73
pubmed: 3559675
Nat Methods. 2014 Apr;11(4):385-92
pubmed: 24562424
Eur J Neurosci. 2018 Oct;48(8):2738-2758
pubmed: 29280209
Psychiatry Res. 2022 Jan;307:114265
pubmed: 34922240
J Psychiatr Res. 2010 Jan;44(2):112-20
pubmed: 19665729
Annu Rev Clin Psychol. 2019 May 7;15:451-479
pubmed: 30786245
J Clin Psychiatry. 2010 Mar;71(3):313-26
pubmed: 20331933
Ann Neurol. 2009 Jul;66(1):11-8
pubmed: 19670433
Am J Psychiatry. 2007 Mar;164(3):483-92
pubmed: 17329474
Behav Brain Res. 1995 Jul-Aug;69(1-2):109-16
pubmed: 7546301
Schizophr Res. 2019 Apr;206:318-324
pubmed: 30377012
Schizophr Bull. 2011 May;37(3):514-23
pubmed: 21505118
Neuropsychopharmacology. 2012 Jan;37(1):4-15
pubmed: 21956446
Psychiatr Clin North Am. 2006 Dec;29(4):1033-45; abstract ix-x
pubmed: 17118280
Biol Psychiatry. 2016 Oct 15;80(8):599-608
pubmed: 26602589
Schizophr Bull. 2013 Jan;39(1):120-9
pubmed: 21746807
NPJ Schizophr. 2017 Feb 3;3:7
pubmed: 28560253
Trends Neurosci. 2013 Dec;36(12):738-48
pubmed: 24210901
Biol Psychiatry. 2012 Jan 15;71(2):154-61
pubmed: 21967958
Neuroscience. 2006;138(1):351-6
pubmed: 16388912
Nat Rev Neurosci. 2008 Dec;9(12):947-57
pubmed: 19002191
Schizophr Res. 2016 Sep;176(1):36-40
pubmed: 25458857
Eur J Neurosci. 2011 Oct;34(7):1031-9
pubmed: 21895800
Front Hum Neurosci. 2017 Sep 05;11:433
pubmed: 28928647
World Psychiatry. 2020 Feb;19(1):15-33
pubmed: 31922684
Schizophr Res. 2015 Sep;167(1-3):98-107
pubmed: 25583246
Front Mol Neurosci. 2019 Jul 31;12:185
pubmed: 31417356
Neuropsychopharmacology. 2020 Dec;45(13):2189-2197
pubmed: 32919407
Nat Commun. 2017 Jun 26;8:15930
pubmed: 28649997
NPJ Schizophr. 2018 Feb 9;4(1):2
pubmed: 29426848
Schizophr Res. 2016 Sep;176(1):41-51
pubmed: 25000913
Lancet Neurol. 2008 Dec;7(12):1091-8
pubmed: 18851928
J Sleep Res. 2021 Apr;30(2):e13039
pubmed: 32350968
J Neurosci. 2008 Apr 2;28(14):3586-94
pubmed: 18385317
Sleep. 2015 Jul 01;38(7):1093-103
pubmed: 25845686
Neuroreport. 2002 Jan 21;13(1):1-4
pubmed: 11924867
Brain Topogr. 2019 Jul;32(4):530-549
pubmed: 31037477
J Neurophysiol. 2001 Sep;86(3):1365-75
pubmed: 11535683

Auteurs

Maria E Dimitriades (ME)

Child Development Center, University Children's Hospital Zurich, Zurich, Switzerland.
Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.

Andjela Markovic (A)

Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland.
University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Department of Psychology, University of Fribourg, Fribourg, Switzerland.

Silvano R Gefferie (SR)

Stichting Epilepsie Instellingen Nederland, Heemstede, Netherlands.
Department of Neurology, Leiden University Medical Center, Leiden, Netherlands.

Ashura Buckley (A)

Pediatrics and Neurodevelopmental Neuroscience, National Institute of Mental Health, Bethesda, MD, United States.

David I Driver (DI)

Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, United States.

Judith L Rapoport (JL)

Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, United States.

Margherita Nosadini (M)

Paediatric Neurology and Neurophysiology Unit, Department of Women's and Children's Health, University Hospital of Padova, Padova, Italy.
Neuroimmunology Group, Paediatric Research Institute Città della Speranza, Padova, Italy.

Kevin Rostasy (K)

Department of Pediatric Neurology, Children's Hospital Datteln, Witten/Herdecke University, Datteln, Germany.

Stefano Sartori (S)

Paediatric Neurology and Neurophysiology Unit, Department of Women's and Children's Health, University Hospital of Padova, Padova, Italy.
Neuroimmunology Group, Paediatric Research Institute Città della Speranza, Padova, Italy.

Agnese Suppiej (A)

Department of Medical Sciences, Pediatric Section, University of Ferrara, Ferrara, Italy.

Salome Kurth (S)

Department of Psychology, University of Fribourg, Fribourg, Switzerland.

Maurizia Franscini (M)

Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Susanne Walitza (S)

Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Neuroscience Center Zurich, University of Zurich and Swiss Federal Institute of Technology Zurich, Zurich, Switzerland.
Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.

Reto Huber (R)

Child Development Center, University Children's Hospital Zurich, Zurich, Switzerland.
Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Neuroscience Center Zurich, University of Zurich and Swiss Federal Institute of Technology Zurich, Zurich, Switzerland.

Leila Tarokh (L)

University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Translational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.

Bigna K Bölsterli (BK)

Child Development Center, University Children's Hospital Zurich, Zurich, Switzerland.
Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
Department of Pediatric Neurology, University Children's Hospital Zurich, Zurich, Switzerland.
Department of Pediatric Neurology, Children's Hospital of Eastern Switzerland, St. Gallen, Switzerland.

Miriam Gerstenberg (M)

Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Classifications MeSH