Risk factors for colonization with multidrug-resistant Gram-negative bacteria and
Humans
Clostridioides difficile
/ genetics
Clostridioides
Long-Term Care
Escherichia coli
/ genetics
Drug Resistance, Multiple, Bacterial
Risk Factors
Anti-Bacterial Agents
/ pharmacology
Carbapenems
/ therapeutic use
Cephalosporins
/ pharmacology
Gram-Negative Bacteria
/ genetics
Prevalence
Gram-Negative Bacterial Infections
/ microbiology
C. difficile
ESBL
LTCF
carbapenem-resistant
carbapenemase
colonization
epidemiology
risk factors
Journal
Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359
Informations de publication
Date de publication:
2023
2023
Historique:
received:
31
01
2023
accepted:
19
05
2023
medline:
30
6
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
epublish
Résumé
Residency in LTCFs increases the likelihood of colonization with multidrug resistant Gram-negative bacteria (MDR-GNB). We assessed the prevalence and risk factors for enteric colonization by III-generation cephalosporins-resistant and carbapenem-resistant (CR) GNB in a large group of LTCFs in a high endemic setting. We also assessed the prevalence and risk factors for A point prevalence survey with rectal screening (RS) was conducted in 27 LTCFs in north Italy. Epidemiological and clinical variables on the survey day, history of hospitalization and surgery within one year, and antibiotics within three months, were collected. The presence of III-generation cephalosporin resistant and CR GNB was assessed using a selective culture on chromogenic medium and PCR for carbapenemase detection. The presence of In the study period 1947 RSs were performed. The prevalence of colonization by at least one GNB resistant to III-generation cephalosporin was 51% ( Antimicrobial stewardship in LTCFs is a critical issue, being previous antibiotic treatment a risk factor for colonization by MDR-GNB. The prevalence of colonization by III-generation cephalosporin and CR GNB among LTCF residents also underlines the importance to adhere to hand hygiene indications, infection prevention and control measures, and environmental hygiene protocols, more achievable than rigorous contact precautions in this type of social setting.
Identifiants
pubmed: 37377644
doi: 10.3389/fcimb.2023.1155320
pmc: PMC10292821
doi:
Substances chimiques
Anti-Bacterial Agents
0
Carbapenems
0
Cephalosporins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1155320Informations de copyright
Copyright © 2023 Azzini, Be, Naso, Lambertenghi, Salerno, Coledan, Bazaj, Mirandola, Miotti, Mazzaferri, Accordini, Lo Cascio and Tacconelli.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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