Mitochondria in Acetaminophen-Induced Liver Injury and Recovery: A Concise Review.
acetaminophen
biogenesis
iron
mitochondria
morphology
paracetamol
spheroid
Journal
Livers
ISSN: 2673-4389
Titre abrégé: Livers
Pays: Switzerland
ID NLM: 9918230902806676
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
medline:
28
6
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
ppublish
Résumé
Mitochondria are critical organelles responsible for the maintenance of cellular energy homeostasis. Thus, their dysfunction can have severe consequences in cells responsible for energy-intensive metabolic function, such as hepatocytes. Extensive research over the last decades have identified compromised mitochondrial function as a central feature in the pathophysiology of liver injury induced by an acetaminophen (APAP) overdose, the most common cause of acute liver failure in the United States. While hepatocyte mitochondrial oxidative and nitrosative stress coupled with induction of the mitochondrial permeability transition are well recognized after an APAP overdose, recent studies have revealed additional details about the organelle's role in APAP pathophysiology. This concise review highlights these new advances, which establish the central role of the mitochondria in APAP pathophysiology, and places them in the context of earlier information in the literature. Adaptive alterations in mitochondrial morphology as well as the role of cellular iron in mitochondrial dysfunction and the organelle's importance in liver recovery after APAP-induced injury will be discussed.
Identifiants
pubmed: 37377765
doi: 10.3390/livers3020014
pmc: PMC10299745
mid: NIHMS1890547
doi:
Types de publication
Journal Article
Langues
eng
Pagination
219-231Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103549
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM118247
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK102142
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK125465
Pays : United States
Déclaration de conflit d'intérêts
Conflicts of Interest: The authors declare no conflict of interest.
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