An epigenetic signature of advanced colorectal cancer metastasis.
Cancer
Clinical genetics
DNA methylation
Transcriptomics
epigenetics
epigenomics
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
16 Jun 2023
16 Jun 2023
Historique:
received:
13
02
2023
revised:
12
04
2023
accepted:
24
05
2023
medline:
28
6
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
epublish
Résumé
Colorectal cancer (CRC) is a leading cause of morbidity and mortality worldwide. The majority of CRC deaths are caused by tumor metastasis, even following treatment. There is strong evidence for epigenetic changes, such as DNA methylation, accompanying CRC metastasis and poorer patient survival. Earlier detection and a better understanding of molecular drivers for CRC metastasis are of critical clinical importance. Here, we identify a signature of advanced CRC metastasis by performing whole genome-scale DNA methylation and full transcriptome analyses of paired primary cancers and liver metastases from CRC patients. We observed striking methylation differences between primary and metastatic pairs. A subset of loci showed coordinated methylation-expression changes, suggesting these are potentially epigenetic drivers that control the expression of critical genes in the metastatic cascade. The identification of CRC epigenomic markers of metastasis has the potential to enable better outcome prediction and lead to the discovery of new therapeutic targets.
Identifiants
pubmed: 37378317
doi: 10.1016/j.isci.2023.106986
pii: S2589-0042(23)01063-5
pmc: PMC10291510
doi:
Types de publication
Journal Article
Langues
eng
Pagination
106986Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Gut. 2022 May;71(5):938-949
pubmed: 34059508
Br J Cancer. 2016 Dec 6;115(12):1565-1574
pubmed: 27855440
J Gastrointest Oncol. 2016 Oct;7(5):713-720
pubmed: 27747085
Nat Genet. 2020 Aug;52(8):790-799
pubmed: 32690948
Carcinogenesis. 2020 Mar 13;41(1):25-35
pubmed: 31111874
Nat Methods. 2015 Apr;12(4):357-60
pubmed: 25751142
Bioinformatics. 2011 Jun 1;27(11):1571-2
pubmed: 21493656
Cell Rep. 2018 Apr 24;23(4):1178-1191
pubmed: 29694894
Signal Transduct Target Ther. 2022 Mar 4;7(1):70
pubmed: 35246503
Nature. 2020 Mar;579(7798):284-290
pubmed: 32103175
Database (Oxford). 2017 Jan 1;2017:
pubmed: 28605766
J Biomed Biotechnol. 2012;2012:741542
pubmed: 23193365
Oncogene. 2017 Oct 5;36(40):5648-5657
pubmed: 28581523
Int J Mol Sci. 2021 Aug 06;22(16):
pubmed: 34445193
Gastroenterology. 2020 Jan;158(2):341-353
pubmed: 31394082
Cancer. 2016 Nov 15;122(21):3277-3287
pubmed: 27417445
Cell. 2017 Feb 9;168(4):670-691
pubmed: 28187288
J Gastrointest Oncol. 2019 Dec;10(6):1183-1192
pubmed: 31949938
Biomed Pharmacother. 2019 Oct;118:109228
pubmed: 31351430
Methods Mol Biol. 2022;2458:3-21
pubmed: 35103959
Oncogene. 2017 Aug 31;36(35):5035-5044
pubmed: 28459462
Nat Genet. 2003 Jan;33(1):49-54
pubmed: 12469122
Biochim Biophys Acta Rev Cancer. 2021 Apr;1875(2):188514
pubmed: 33497709
Cancers (Basel). 2019 May 07;11(5):
pubmed: 31067629
Science. 2018 Nov 30;362(6418):1060-1063
pubmed: 30498128
Semin Cancer Biol. 2018 Aug;51:149-159
pubmed: 28807546
World J Gastroenterol. 2015 Nov 7;21(41):11767-76
pubmed: 26557001
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
Genes Dev. 2020 Dec 1;34(23-24):1577-1598
pubmed: 33262145
Nat Genet. 2017 Mar;49(3):358-366
pubmed: 28092682
Epigenetics Chromatin. 2015 Jun 23;8:22
pubmed: 26113876
Trends Immunol. 2019 Apr;40(4):328-344
pubmed: 30853334
Sci Rep. 2021 Jul 22;11(1):15040
pubmed: 34294834
Methods Mol Biol. 2022;2458:63-74
pubmed: 35103962
World J Gastroenterol. 2010 May 21;16(19):2421-7
pubmed: 20480530
Mol Oncol. 2017 Jan;11(1):97-119
pubmed: 28085225
Nat Rev Clin Oncol. 2019 Mar;16(3):185-204
pubmed: 30514977
Neoplasia. 2013 Feb;15(2):204-17
pubmed: 23441134
Front Cell Dev Biol. 2021 Jun 23;9:617549
pubmed: 34249900
Nat Med. 2018 Dec;24(12):1930-1939
pubmed: 30397358
Biochem J. 2021 Sep 17;478(17):3373-3393
pubmed: 34520519
Sci Rep. 2017 Oct 23;7(1):13806
pubmed: 29061982
Methods Mol Biol. 2023;2588:249-278
pubmed: 36418693
Cancers (Basel). 2019 Oct 09;11(10):
pubmed: 31600992
Curr Protoc. 2021 Mar;1(3):e90
pubmed: 33780170
J Pathol. 2013 Apr;229(5):697-704
pubmed: 23096130
Clin Epigenetics. 2016 Mar 02;8:25
pubmed: 26941852
Science. 1976 Oct 1;194(4260):23-8
pubmed: 959840
Nat Commun. 2020 Oct 9;11(1):5120
pubmed: 33037194
CA Cancer J Clin. 2016 Jan-Feb;66(1):7-30
pubmed: 26742998
Signal Transduct Target Ther. 2020 Mar 12;5(1):28
pubmed: 32296047
Asian Pac J Cancer Prev. 2013;14(2):1003-7
pubmed: 23621176
Gastroenterology. 2016 Nov;151(5):961-972
pubmed: 27521480
Cell. 2015 Aug 27;162(5):961-73
pubmed: 26317465
Carcinogenesis. 2013 Nov;34(11):2647-54
pubmed: 23764754
Br J Cancer. 2021 Apr;124(9):1491-1502
pubmed: 33731858
J Mol Cell Biol. 2020 Feb 20;12(2):125-137
pubmed: 31065671
J Invest Dermatol. 2020 Dec;140(12):2442-2454.e5
pubmed: 32360600
Mol Diagn Ther. 2017 Apr;21(2):153-165
pubmed: 27878475
Front Oncol. 2020 Jul 23;10:1066
pubmed: 32793471
Nature. 2012 Jul 18;487(7407):330-7
pubmed: 22810696
Am J Transl Res. 2020 Aug 15;12(8):4141-4159
pubmed: 32913494
Nucleic Acids Res. 2012 May;40(10):e79
pubmed: 22344695
Cancer Discov. 2022 Jan;12(1):31-46
pubmed: 35022204
Sci Rep. 2017 Sep 14;7(1):11590
pubmed: 28912574
Oncotarget. 2017 Jan 24;8(4):6085-6101
pubmed: 28030832
Nat Commun. 2013;4:2612
pubmed: 24113773
Protein Cell. 2022 Dec;13(12):877-919
pubmed: 34050894
Genome Res. 2012 Sep;22(9):1680-8
pubmed: 22955980
Hum Pathol. 2022 Jan;119:1-14
pubmed: 34655611
Eur J Cancer. 2001 Dec;37(18):2392-7
pubmed: 11720833
Trends Cancer. 2022 Mar;8(3):226-241
pubmed: 34952829
Bioinformatics. 2010 Mar 15;26(6):841-2
pubmed: 20110278
iScience. 2018 Jun 29;4:312-325
pubmed: 30240750
Genes (Basel). 2019 Feb 12;10(2):
pubmed: 30759871
Oxid Med Cell Longev. 2021 Aug 14;2021:6290261
pubmed: 34497681
Bioinformatics. 2014 Jul 1;30(13):1814-22
pubmed: 24608764
CA Cancer J Clin. 2013 Jan;63(1):11-30
pubmed: 23335087
Nucleic Acids Res. 2020 Jul 2;48(W1):W509-W514
pubmed: 32442275
J Biol Chem. 2020 Feb 21;295(8):2495-2505
pubmed: 31937589
Scand J Immunol. 2022 Feb;95(2):e13119
pubmed: 34796980