Prolonged dysbiosis and altered immunity under nutritional intervention in a physiological mouse model of severe acute malnutrition.
Gastroenterology
Immunology
Microbiome
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
16 Jun 2023
16 Jun 2023
Historique:
received:
24
01
2023
revised:
03
04
2023
accepted:
12
05
2023
medline:
28
6
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
epublish
Résumé
Severe acute malnutrition (SAM) is a multifactorial disease affecting millions of children worldwide. It is associated with changes in intestinal physiology, microbiota, and mucosal immunity, emphasizing the need for multidisciplinary studies to unravel its full pathogenesis. We established an experimental model in which weanling mice fed a high-deficiency diet mimic key anthropometric and physiological features of SAM in children. This diet alters the intestinal microbiota (less segmented filamentous bacteria, spatial proximity to epithelium), metabolism (decreased butyrate), and immune cell populations (depletion of LysoDC in Peyer's patches and intestinal Th17 cells). A nutritional intervention leads to a fast zoometric and intestinal physiology recovery but to an incomplete restoration of the intestinal microbiota, metabolism, and immune system. Altogether, we provide a preclinical model of SAM and have identified key markers to target with future interventions during the education of the immune system to improve SAM whole defects.
Identifiants
pubmed: 37378323
doi: 10.1016/j.isci.2023.106910
pii: S2589-0042(23)00987-2
pmc: PMC10291336
doi:
Types de publication
Journal Article
Langues
eng
Pagination
106910Informations de copyright
© 2023 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no competing interests.
Références
Gastroenterology. 2010 Jan;138(1):173-84.e1-3
pubmed: 19800337
Am J Trop Med Hyg. 2012 May;86(5):756-63
pubmed: 22556071
Nat Commun. 2015 Aug 04;6:7806
pubmed: 26241678
SCN News. 1995;(12):10-4
pubmed: 12346313
Bioinformatics. 2011 Nov 1;27(21):2957-63
pubmed: 21903629
Nature. 2014 Jun 19;510(7505):417-21
pubmed: 24896187
Science. 2023 Feb 24;379(6634):826-833
pubmed: 36821686
Bioinformatics. 2011 Mar 15;27(6):863-4
pubmed: 21278185
Cell Rep. 2015 May 5;11(5):770-84
pubmed: 25921539
J Nutr. 2012 Feb;142(2):271-7
pubmed: 22190022
Annu Rev Immunol. 2018 Apr 26;36:359-381
pubmed: 29400985
Science. 2013 Feb 1;339(6119):548-54
pubmed: 23363771
EBioMedicine. 2015 Sep 25;2(11):1759-66
pubmed: 26870801
Immunity. 2019 May 21;50(5):1276-1288.e5
pubmed: 30902637
Science. 2016 May 13;352(6287):aaf4822
pubmed: 27174992
Immunity. 2009 Oct 16;31(4):677-89
pubmed: 19833089
Mucosal Immunol. 2010 Mar;3(2):148-58
pubmed: 19940845
Gut. 1971 Mar;12(3):230-5
pubmed: 4928173
Clin Nutr. 2019 Apr;38(2):615-630
pubmed: 29496274
Sci Rep. 2016 Sep 23;6:33721
pubmed: 27659943
Front Microbiol. 2023 Feb 02;14:1117644
pubmed: 36819064
Sci Rep. 2017 Mar 02;7:43412
pubmed: 28252026
mBio. 2015 Nov 17;6(6):e01453-15
pubmed: 26578675
Microbiome. 2020 Jul 27;8(1):113
pubmed: 32718353
mBio. 2012 May 22;3(3):
pubmed: 22617141
Cell Host Microbe. 2015 Nov 11;18(5):582-92
pubmed: 26526499
Nat Commun. 2022 Dec 8;13(1):7576
pubmed: 36481684
Sci Rep. 2021 Apr 7;11(1):7635
pubmed: 33828139
Nat Methods. 2016 Jul;13(7):581-3
pubmed: 27214047
Appl Environ Microbiol. 1990 Jun;56(6):1919-25
pubmed: 2200342
Immunity. 2019 Feb 19;50(2):446-461.e9
pubmed: 30709742
Nat Rev Gastroenterol Hepatol. 2022 Oct;19(10):625-637
pubmed: 35641786
Microorganisms. 2020 Apr 03;8(4):
pubmed: 32260190
Int J Syst Evol Microbiol. 2020 Nov;70(11):5972-6016
pubmed: 33151140
Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):E5934-E5943
pubmed: 27638207
Int J Mol Sci. 2021 May 08;22(9):
pubmed: 34066870
Curr Opin Microbiol. 2017 Feb;35:100-109
pubmed: 28453971
Bioinformatics. 2014 Aug 1;30(15):2114-20
pubmed: 24695404
Front Nutr. 2019 Apr 17;6:48
pubmed: 31058161
Nutrients. 2019 Sep 16;11(9):
pubmed: 31527523
Science. 2016 Feb 19;351(6275):
pubmed: 26912898
Am J Transl Res. 2013 Aug 15;5(5):543-54
pubmed: 23977413
Sci Rep. 2021 Jun 1;11(1):11494
pubmed: 34075098
Front Immunol. 2019 Jul 29;10:1728
pubmed: 31417545
Front Immunol. 2017 Oct 02;8:1254
pubmed: 29038658
Microorganisms. 2018 Jul 23;6(3):
pubmed: 30041463
Nucleic Acids Res. 2010 Jul;38(Web Server issue):W71-7
pubmed: 20457745
Pac Symp Biocomput. 2012;:247-58
pubmed: 22174280
Int J Inflam. 2010 Sep 19;2010:823710
pubmed: 21188221
J Nutr. 2014 Mar;144(3):273-81
pubmed: 24381221
Future Microbiol. 2017 Feb;12:157-170
pubmed: 28139139
Neurogastroenterol Motil. 2020 Dec;32(12):e13936
pubmed: 33021011
J Nutr. 2016 Dec;146(12):2436-2444
pubmed: 27807038
Infect Immun. 1974 Oct;10(4):948-56
pubmed: 4426712
Immunity. 2014 Apr 17;40(4):608-20
pubmed: 24745335
Nat Commun. 2021 Nov 25;12(1):6860
pubmed: 34824233
J Nutr Biochem. 2015 Oct;26(10):1050-7
pubmed: 26070414
BMJ Open. 2019 Feb 1;9(1):e023077
pubmed: 30782694
Front Microbiol. 2017 May 23;8:899
pubmed: 28588566
Science. 2019 Jul 12;365(6449):
pubmed: 31296738
Sci Transl Med. 2015 Feb 25;7(276):276ra24
pubmed: 25717097
Am J Clin Nutr. 2016 Nov;104(5):1441-1449
pubmed: 27655441
Immunol Cell Biol. 2014 Jan;92(1):49-56
pubmed: 24100385
PLoS One. 2016 Sep 30;11(9):e0158772
pubmed: 27690129
Science. 2019 Jul 12;365(6449):
pubmed: 31296739
PLoS One. 2014 Jun 03;9(6):e96030
pubmed: 24892281
Physiol Rep. 2018 Dec;6(23):e13932
pubmed: 30516001
Cell. 2022 Sep 15;185(19):3501-3519.e20
pubmed: 36041436
Microorganisms. 2020 Apr 15;8(4):
pubmed: 32326636
Eur J Nutr. 2019 Apr;58(3):909-930
pubmed: 29644395
BMC Biol. 2019 Oct 28;17(1):83
pubmed: 31660948
FEMS Microbiol Ecol. 2017 Dec 1;93(12):
pubmed: 29126267
Microb Pathog. 2017 May;106:171-181
pubmed: 26875998
Genome Biol. 2011 Jun 24;12(6):R60
pubmed: 21702898
PLoS One. 2013 Jun 25;8(6):e66698
pubmed: 23825556
Nutrients. 2018 Jun 05;10(6):
pubmed: 29874829
Int J Syst Bacteriol. 1995 Oct;45(4):780-2
pubmed: 7547299
Appl Environ Microbiol. 2005 Dec;71(12):8228-35
pubmed: 16332807
Proc Natl Acad Sci U S A. 2022 Oct 11;119(41):e2209589119
pubmed: 36197997
Trends Immunol. 2016 Jun;37(6):386-398
pubmed: 27237815
J Nutr. 1986 Jul;116(7):1209-24
pubmed: 3746459
J Nutr. 2016 May;146(5):940-8
pubmed: 27052538
Sci Rep. 2020 Sep 24;10(1):15581
pubmed: 32973261
Sci Rep. 2016 May 18;6:26276
pubmed: 27188959
Gut Microbes. 2020 Jul 3;11(4):855-867
pubmed: 31959047
J Immunol. 2009 Aug 15;183(4):2818-26
pubmed: 19625645
FEBS J. 2022 Aug;289(16):4731-4757
pubmed: 34076962
Immunity. 2021 Aug 10;54(8):1745-1757.e7
pubmed: 34348118
Gastroenterology. 2012 Mar;142(3):592-601.e3
pubmed: 22155637
Cell. 2009 Oct 30;139(3):485-98
pubmed: 19836068
PLoS One. 2016 May 26;11(5):e0155405
pubmed: 27228122
Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8489-E8498
pubmed: 30126990
Cell Rep. 2020 Apr 7;31(1):107479
pubmed: 32268097
Nat Biotechnol. 2019 Aug;37(8):852-857
pubmed: 31341288
J Parasitol. 2011 Dec;97(6):1113-20
pubmed: 21711105