Attenuated

Immunology Medical microbiology

Journal

iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038

Informations de publication

Date de publication:
16 Jun 2023
Historique:
received: 23 01 2023
revised: 12 05 2023
accepted: 22 05 2023
medline: 28 6 2023
pubmed: 28 6 2023
entrez: 28 6 2023
Statut: epublish

Résumé

Bacillus Calmette-Guérin (BCG) remains the only approved tuberculosis (TB) vaccine despite limited efficacy. Preclinical studies of next-generation TB vaccines typically use a murine aerosol model with a supraphysiologic challenge dose. Here, we show that the protective efficacy of a live attenuated

Identifiants

pubmed: 37378347
doi: 10.1016/j.isci.2023.106963
pii: S2589-0042(23)01040-4
pmc: PMC10291467
doi:

Types de publication

Journal Article

Langues

eng

Pagination

106963

Informations de copyright

© 2023 The Authors.

Déclaration de conflit d'intérêts

A.J.M. and D.H.B. are co-inventors on a provisional vaccine patent PCT/US2020/059152 (Mycobacterial compositions and biomarkers for use in treatment and monitoring of therapeutic responsiveness).

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Auteurs

Samuel J Vidal (SJ)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Daniel Sellers (D)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Jingyou Yu (J)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Shoko Wakabayashi (S)

Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Jaimie Sixsmith (J)

Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Malika Aid (M)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Julia Barrett (J)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Sage F Stevens (SF)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Xiaowen Liu (X)

Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Wenjun Li (W)

Department of Public Health, University of Massachusetts Lowell, Lowell, MA, USA.

Courtney R Plumlee (CR)

Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.

Kevin B Urdahl (KB)

Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.
Department of Pediatrics, University of Washington, Seattle, WA, USA.
Department of Immunology, University of Washington, Seattle, WA, USA.

Amanda J Martinot (AJ)

Department of Infectious Diseases and Global Health, Tufts University Cummings School of Veterinary Medicine, North Grafton, MA, USA.

Dan H Barouch (DH)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.

Classifications MeSH