Sudden cardiac death in a young male endurance athlete.
Journal
Journal of osteopathic medicine
ISSN: 2702-3648
Titre abrégé: J Osteopath Med
Pays: Germany
ID NLM: 101776472
Informations de publication
Date de publication:
01 09 2023
01 09 2023
Historique:
received:
23
04
2023
accepted:
08
06
2023
medline:
24
8
2023
pubmed:
28
6
2023
entrez:
28
6
2023
Statut:
epublish
Résumé
Sudden cardiac death (SCD) is a rare yet devastating event that can occur in young athletes. Although hypertrophic obstructive cardiomyopathy is the most common cause of SCD, some other genetic abnormalities have been identified as proarrhythmic. However, there is not routine screening for these other genetic abnormalities. Furthermore, consumption of caffeine, stimulant medication, or prolonged exercise can potentiate the underlying arrhythmic potential. In the event of SCD, advanced cardiac life support (ACLS) should be performed immediately and exactly. The authors present a case of an otherwise healthy young male who collapsed during a marathon and could not be resuscitated despite aggressive measures. After aggressive resuscitative efforts, the patient ultimately expired. A postmortem autopsy revealed no cardiac structural abnormalities, and the cause of death was determined to be cardiac arrhythmia of undetermined etiology. Postmortem genetic testing revealed a heterozygous variation in calcium voltage-gated channel auxiliary subunit beta 2 (CACNB2), a gene associated with arrhythmia and calcium channelopathy. Toxicology showed therapeutic levels of amphetamine. This case highlights the eminent risk of cardiac death in young athletes with proarrhythmic genetic variations, especially in the setting of endurance sport.
Identifiants
pubmed: 37378586
pii: jom-2023-0097
doi: 10.1515/jom-2023-0097
doi:
Substances chimiques
Calcium
SY7Q814VUP
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
461-465Informations de copyright
© 2023 the author(s), published by De Gruyter, Berlin/Boston.
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