Long non-coding RNA mitophagy and ALK-negative anaplastic lymphoma-associated transcript: a novel regulator of mitophagy in T-cell lymphoma.

Humans Receptor Protein-Tyrosine Kinases / genetics Anaplastic Lymphoma Kinase / genetics RNA, Long Noncoding / genetics Mitophagy / genetics Retrospective Studies Lymphoma, T-Cell, Peripheral Lymphoma, Large-Cell, Anaplastic / pathology

Journal

Haematologica

ISSN: 1592-8721

Titre abrégé: Haematologica

Pays: Italy

ID NLM: 0417435

Informations de publication

Date de publication:
01 Dec 2023

Historique:

received: 14 12 2022

medline: 4 12 2023

pubmed: 29 6 2023

entrez: 29 6 2023

Statut: epublish

Résumé

Long non-coding RNA (lncRNA) are emerging as powerful and versatile regulators of transcriptional programs and distinctive biomarkers of progression of T-cell lymphoma. Their role in the aggressive anaplastic lymphoma kinase-negative (ALK-) subtype of anaplastic large cell lymphoma (ALCL) has been elucidated only in part. Starting from our previously identified ALCL-associated lncRNA signature and performing digital gene expression profiling of a retrospective cohort of ALCL, we defined an 11 lncRNA signature able to discriminate among ALCL subtypes. We selected a not previously characterized lncRNA, MTAAT, with preferential expression in ALK- ALCL, for molecular and functional studies. We demonstrated that lncRNA MTAAT contributes to an aberrant mitochondrial turnover restraining mitophagy and promoting cellular proliferation. Functionally, lncRNA MTAAT acts as a repressor of a set of genes related to mitochondrial quality control via chromatin reorganization. Collectively, our work demonstrates the transcriptional role of lncRNA MTAAT in orchestrating a complex transcriptional program sustaining the progression of ALK- ALCL.

Identifiants

DOI: 10.3324/haematol.2022.282552 PMID: 37381763 PMC: PMC10690924

pubmed: 37381763

doi: 10.3324/haematol.2022.282552

pmc: PMC10690924

doi:

Substances chimiques

Receptor Protein-Tyrosine Kinases EC 2.7.10.1

Anaplastic Lymphoma Kinase EC 2.7.10.1

RNA, Long Noncoding 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

3333-3346

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