Homocysteine-a retrospective and prospective appraisal.
Alzheimer’s disease
dementia
folate
homocysteine
inborn errors of metabolism
neural tube defects
vascular disease
vitamin B12
Journal
Frontiers in nutrition
ISSN: 2296-861X
Titre abrégé: Front Nutr
Pays: Switzerland
ID NLM: 101642264
Informations de publication
Date de publication:
2023
2023
Historique:
received:
04
03
2023
accepted:
22
05
2023
medline:
29
6
2023
pubmed:
29
6
2023
entrez:
29
6
2023
Statut:
epublish
Résumé
The biologically important amino acid homocysteine links sulfur, methionine, and one-carbon metabolism. This review describes its initial discovery, the identification of the clinical condition of "homocystinuria" and the recognition of its close relationship to folate and vitamin B12 metabolism. It discusses the history behind its current association with diverse diseases including neural tube defects, cardio- and cerebrovascular disease and, more recently, dementia and Alzheimer's Disease. It also explores current controversies and considers potential future research directions. It is intended to give a general overview of homocysteine in relation to health and disease.
Identifiants
pubmed: 37384104
doi: 10.3389/fnut.2023.1179807
pmc: PMC10294675
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1179807Informations de copyright
Copyright © 2023 McCaddon and Miller.
Déclaration de conflit d'intérêts
AM is a shareholder and Scientific Advisor for COBALZ Limited, a private Limited Company developing novel B-vitamin and antioxidant supplements. JM receives compensation as Associate Editor for the journal Nutrition Reviews, and has received within the last 3 years consulting compensation from Church and Dwight, Inc., a producer and seller of consumer goods including vitamin supplements. The study received funding from COBALZ Limited. The funder had the following involvement: APC costs.
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