The sparing effect of FLASH-RT on synaptic plasticity is maintained in mice with standard fractionation.

Mice Animals Neuronal Plasticity / physiology Long-Term Potentiation / physiology Hippocampus / physiology Synaptic Transmission / physiology
FLASH radiotherapy Long-term potentiation Standard-of care fractionation

Journal

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
ISSN: 1879-0887
Titre abrégé: Radiother Oncol
Pays: Ireland
ID NLM: 8407192

Informations de publication

Date de publication:
09 2023
Historique:
received: 07 03 2023
revised: 20 06 2023
accepted: 20 06 2023
medline: 21 8 2023
pubmed: 30 6 2023
entrez: 29 6 2023
Statut: ppublish

Résumé

Long-term potentiation (LTP) was used to gauge the impact of conventional and FLASH dose rates on synaptic transmission. Data collected from the hippocampus and medial prefrontal cortex confirmed significant inhibition of LTP after 10 fractions of 3 Gy (30 Gy total) conventional radiotherapy. Remarkably, 10x3Gy FLASH radiotherapy and unirradiated controls were identical and exhibited normal LTP.

Identifiants

DOI: 10.1016/j.radonc.2023.109767 PMID: 37385377
pubmed: 37385377
pii: S0167-8140(23)00305-5
doi: 10.1016/j.radonc.2023.109767
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

109767

Subventions

Organisme : NCI NIH HHS
ID : P01 CA244091
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA254892
Pays : United States

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Charles L Limoli (CL)

Department of Radiation Oncology, University of California, Irvine, CA 92697-2695, USA. Electronic address: climoli@uci.edu.

Eniko A Kramár (EA)

Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.

Aymeric Almeida (A)

Laboratory of Radiation Oncology, Department of Radiation Oncology. Lausanne University Hospital and University of Lausanne, Switzerland.

Benoit Petit (B)

Laboratory of Radiation Oncology, Department of Radiation Oncology. Lausanne University Hospital and University of Lausanne, Switzerland.

Veljko Grilj (V)

Laboratory of Radiation Oncology, Department of Radiation Oncology. Lausanne University Hospital and University of Lausanne, Switzerland.

Janet E Baulch (JE)

Department of Radiation Oncology, University of California, Irvine, CA 92697-2695, USA.

Paola Ballesteros-Zebadua (P)

Laboratory of Radiation Oncology, Department of Radiation Oncology. Lausanne University Hospital and University of Lausanne, Switzerland; Laboratorio de Fisica Medica, Instituto Nacional de Neurología y Neurocirugía MVS, México City 14269, Mexico.

Billy W Loo (BW)

Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Marcelo A Wood (MA)

Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.

Marie-Catherine Vozenin (MC)

Laboratory of Radiation Oncology, Department of Radiation Oncology. Lausanne University Hospital and University of Lausanne, Switzerland. Electronic address: marie-catherine.vozenin@chuv.ch.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The sparing effect of FLASH-RT on synaptic...
questionsmedicales.fr › Eucaryotes › Animaux › The sparing effect of FLASH-RT on synaptic...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Plasticité neuronale › The sparing effect of FLASH-RT on synaptic...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Plasticité neuronale › Potentialisation à long terme › The sparing effect of FLASH-RT on synaptic...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › The sparing effect of FLASH-RT on synaptic...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transmission synaptique › The sparing effect of FLASH-RT on synaptic...