A selective autophagy receptor VISP1 induces symptom recovery by targeting viral silencing suppressors.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
29 06 2023
29 06 2023
Historique:
received:
24
08
2022
accepted:
09
06
2023
medline:
3
7
2023
pubmed:
30
6
2023
entrez:
29
6
2023
Statut:
epublish
Résumé
Selective autophagy is a double-edged sword in antiviral immunity and regulated by various autophagy receptors. However, it remains unclear how to balance the opposite roles by one autophagy receptor. We previously identified a virus-induced small peptide called VISP1 as a selective autophagy receptor that facilitates virus infections by targeting components of antiviral RNA silencing. However, we show here that VISP1 can also inhibit virus infections by mediating autophagic degradation of viral suppressors of RNA silencing (VSRs). VISP1 targets the cucumber mosaic virus (CMV) 2b protein for degradation and attenuates its suppression activity on RNA silencing. Knockout and overexpression of VISP1 exhibit compromised and enhanced resistance against late infection of CMV, respectively. Consequently, VISP1 induces symptom recovery from CMV infection by triggering 2b turnover. VISP1 also targets the C2/AC2 VSRs of two geminiviruses and enhances antiviral immunity. Together, VISP1 induces symptom recovery from severe infections of plant viruses through controlling VSR accumulation.
Identifiants
pubmed: 37385991
doi: 10.1038/s41467-023-39426-0
pii: 10.1038/s41467-023-39426-0
pmc: PMC10310818
doi:
Substances chimiques
Antiviral Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3852Informations de copyright
© 2023. The Author(s).
Références
Plant Cell. 2020 Sep;32(9):2878-2897
pubmed: 32641349
J Mol Biol. 2020 Jan 3;432(1):80-103
pubmed: 31310766
Cell Host Microbe. 2010 Jul 22;8(1):12-5
pubmed: 20638637
Cell. 2019 Apr 18;177(3):766-781.e24
pubmed: 30955882
Plant Cell. 2011 Jan;23(1):273-88
pubmed: 21245466
Plant Physiol. 2018 Feb;176(2):1587-1597
pubmed: 29184028
Genes Dev. 2006 Dec 1;20(23):3255-68
pubmed: 17158744
J Gen Virol. 2021 Dec;102(12):
pubmed: 34919512
Elife. 2022 Feb 22;11:
pubmed: 35191833
Plant Physiol. 2018 Jan;176(1):649-662
pubmed: 29133371
New Phytol. 2021 Jan;229(2):1036-1051
pubmed: 32898938
Virology. 2014 Jul;460-461:108-18
pubmed: 25010276
J Virol. 2005 Jun;79(11):7217-26
pubmed: 15890960
Plant J. 2002 Aug;31(3):375-83
pubmed: 12164816
Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):484-9
pubmed: 19966292
Trends Plant Sci. 2017 Aug;22(8):646-648
pubmed: 28633985
Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2395-400
pubmed: 23341627
Front Plant Sci. 2020 May 19;11:591
pubmed: 32508858
Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E2026-E2035
pubmed: 28223514
Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):10113-8
pubmed: 22665793
Front Cell Infect Microbiol. 2022 Jan 03;11:786348
pubmed: 35047417
Elife. 2017 Feb 28;6:
pubmed: 28244873
Curr Opin Virol. 2018 Oct;32:88-99
pubmed: 30388659
Plant J. 2004 Nov;40(3):428-38
pubmed: 15469500
Plant Cell. 2007 Jun;19(6):2053-63
pubmed: 17586651
Sci Rep. 2019 Feb 28;9(1):3187
pubmed: 30816193
Annu Rev Virol. 2020 Sep 29;7(1):403-419
pubmed: 32530794
Mol Plant Pathol. 2016 Feb;17(2):173-83
pubmed: 25893424
PLoS Pathog. 2017 Jul 20;13(7):e1006522
pubmed: 28727810
PLoS Pathog. 2017 Feb 17;13(2):e1006213
pubmed: 28212430
Plant Cell. 2014 Dec;26(12):4991-5008
pubmed: 25490915
Nat Rev Immunol. 2019 Jan;19(1):31-44
pubmed: 30301972
Nat Commun. 2022 May 30;13(1):2994
pubmed: 35637208
Cell. 2000 May 26;101(5):533-42
pubmed: 10850495
Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15942-6
pubmed: 23019378
PLoS Pathog. 2015 Oct 02;11(10):e1005196
pubmed: 26431425
Mol Cell. 2015 Jun 18;58(6):1053-66
pubmed: 26004230
J Virol. 2006 Jun;80(12):5747-56
pubmed: 16731914
Trends Plant Sci. 2019 May;24(5):413-430
pubmed: 30824355
Front Microbiol. 2021 Apr 09;12:645419
pubmed: 33897657
Nat Rev Microbiol. 2018 Jun;16(6):341-354
pubmed: 29556036
New Phytol. 2019 May;222(3):1458-1473
pubmed: 30664234
Plant Cell. 2018 Jul;30(7):1582-1595
pubmed: 29848767
Front Microbiol. 2016 Aug 24;7:1329
pubmed: 27605926
J Virol. 2016 Dec 16;91(1):
pubmed: 27795417
Autophagy. 2022 Jun;18(6):1450-1462
pubmed: 34740306
J Virol. 2005 Feb;79(4):2517-27
pubmed: 15681452
Plant Cell. 2015 Aug;27(8):2095-118
pubmed: 26276833
Annu Rev Biochem. 2017 Jun 20;86:193-224
pubmed: 28460188
New Phytol. 2020 Feb;225(4):1746-1761
pubmed: 31621924
Curr Opin Plant Biol. 2017 Dec;40:122-130
pubmed: 28946008
Proc Natl Acad Sci U S A. 2019 Nov 5;116(45):22872-22883
pubmed: 31628252
Nature. 2006 Nov 16;444(7117):323-9
pubmed: 17108957
Science. 2000 Oct 6;290(5489):142-4
pubmed: 11021800
EMBO J. 2022 Dec 17;41(2):e108713
pubmed: 34888888
Plant Cell. 2022 Jul 30;34(8):3110-3127
pubmed: 35567529
Nat Rev Immunol. 2010 Sep;10(9):632-44
pubmed: 20706278
Annu Rev Cell Dev Biol. 2021 Oct 6;37:143-169
pubmed: 34152791
Nat Commun. 2018 Mar 28;9(1):1268
pubmed: 29593293
EMBO J. 2021 Aug 2;40(15):e108050
pubmed: 34155657
New Phytol. 2018 Jun;218(4):1570-1585
pubmed: 29453938
Annu Rev Plant Biol. 2018 Apr 29;69:173-208
pubmed: 29539270
Virology. 2006 Jan 5;344(1):158-68
pubmed: 16364747
Plant Cell. 2012 Jan;24(1):259-74
pubmed: 22247253
FEBS Lett. 2009 Apr 17;583(8):1261-6
pubmed: 19332064