Ferroptosis and the bidirectional regulatory factor p53.
Journal
Cell death discovery
ISSN: 2058-7716
Titre abrégé: Cell Death Discov
Pays: United States
ID NLM: 101665035
Informations de publication
Date de publication:
29 Jun 2023
29 Jun 2023
Historique:
received:
15
11
2022
accepted:
22
06
2023
revised:
16
06
2023
medline:
30
6
2023
pubmed:
30
6
2023
entrez:
29
6
2023
Statut:
epublish
Résumé
Ferroptosis is a type of regulated cell death characterized by iron-mediated lipid peroxidation, in contrast with apoptosis, autophagy, and necrosis. It can be triggered by many pathological processes, including cellular metabolism, tumors, neurodegenerative diseases, cardiovascular diseases, and ischemia-reperfusion injuries. In recent years, ferroptosis has been discovered to be associated with p53. P53 is a tumor suppressor protein with multiple and powerful functions in cell cycle arrest, senescence, cell death, repair of DNA damage, and mitophagy. Emerging evidence shows that ferroptosis plays a crucial role in tumor suppression by p53. P53 functions as a key bidirectional regulator of ferroptosis by adjusting metabolism of iron, lipids, glutathione peroxidase 4, reactive oxygen species, and amino acids via a canonical pathway. In addition, a noncanonical pathway of p53 that regulates ferroptosis has been discovered in recent years. The specific details require to be further clarified. These mechanisms provide new ideas for clinical applications, and translational studies of ferroptosis have been performed to treat various diseases.
Identifiants
pubmed: 37386007
doi: 10.1038/s41420-023-01517-8
pii: 10.1038/s41420-023-01517-8
pmc: PMC10310766
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
197Subventions
Organisme : Department of Science and Technology of Jilin Province (Jilin Province Science and Technology Department)
ID : 20210401174YY
Organisme : Department of Science and Technology of Jilin Province (Jilin Province Science and Technology Department)
ID : YDZJ202201ZYTS092
Informations de copyright
© 2023. The Author(s).
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