GABA decrease is associated with degraded neural specificity in the visual cortex of glaucoma patients.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
29 06 2023
29 06 2023
Historique:
received:
23
11
2022
accepted:
05
05
2023
medline:
3
7
2023
pubmed:
30
6
2023
entrez:
29
6
2023
Statut:
epublish
Résumé
Glaucoma is an age-related neurodegenerative disease of the visual system, affecting both the eye and the brain. Yet its underlying metabolic mechanisms and neurobehavioral relevance remain largely unclear. Here, using proton magnetic resonance spectroscopy and functional magnetic resonance imaging, we investigated the GABAergic and glutamatergic systems in the visual cortex of glaucoma patients, as well as neural specificity, which is shaped by GABA and glutamate signals and underlies efficient sensory and cognitive functions. Our study shows that among the older adults, both GABA and glutamate levels decrease with increasing glaucoma severity regardless of age. Further, our study shows that the reduction of GABA but not glutamate predicts the neural specificity. This association is independent of the impairments on the retina structure, age, and the gray matter volume of the visual cortex. Our results suggest that glaucoma-specific decline of GABA undermines neural specificity in the visual cortex and that targeting GABA could improve the neural specificity in glaucoma.
Identifiants
pubmed: 37386293
doi: 10.1038/s42003-023-04918-8
pii: 10.1038/s42003-023-04918-8
pmc: PMC10310759
doi:
Substances chimiques
Glutamic Acid
3KX376GY7L
gamma-Aminobutyric Acid
56-12-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
679Subventions
Organisme : NIBIB NIH HHS
ID : P41 EB017183
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY013178
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY028125
Pays : United States
Informations de copyright
© 2023. The Author(s).
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