Connecting the use of innovative treatments and glucocorticoids with the multidisciplinary evaluation through rule-based natural-language processing: a real-world study on patients with rheumatoid arthritis, psoriatic arthritis, and psoriasis.

Background

The impact of a multidisciplinary management of rheumatoid arthritis (RA), psoriatic arthritis (PsA), and psoriasis on systemic glucocorticoids or innovative treatments remains unknown. Rule-based natural language processing and text extraction help to manage large datasets of unstructured information and provide insights into the profile of treatment choices.

Methods

We obtained structured information from text data of outpatient visits between 2017 and 2022 using regular expressions (RegEx) to define elastic search patterns and to consider only affirmative citation of diseases or prescribed therapy by detecting negations. Care processes were described by binary flags which express the presence of RA, PsA and psoriasis and the prescription of glucocorticoids and biologics or small molecules in each cases. Logistic regression analyses were used to train the classifier to predict outcomes using the number of visits and the other specialist visits as the main variables.

Results

We identified 1743 patients with RA, 1359 with PsA and 2,287 with psoriasis, accounting for 5,677, 4,468 and 7,770 outpatient visits, respectively. Among these, 25% of RA, 32% of PsA and 25% of psoriasis cases received biologics or small molecules, while 49% of RA, 28% of PsA, and 40% of psoriasis cases received glucocorticoids. Patients evaluated also by other specialists were treated more frequently with glucocorticoids (70% vs. 49% for RA, 60% vs. 28% for PsA, 51% vs. 40% for psoriasis;

Conclusion

Patients with RA, PsA, or psoriasis undergoing multiple evaluations are more likely to receive innovative treatments or glucocorticoids, possibly reflecting more complex cases.

Informations de copyright

Copyright © 2023 Motta, Morandini, Maffia, Vecellio, Tonutti, De Santis, Costanzo, Puggioni, Savevski and Selmi.

Déclaration de conflit d'intérêts

FP received reimbursements for lectures, presentations, speakers bureaus, and manuscript writing or educational events from AstraZeneca, Mundipharma, Menarini, Almirall, Chiesi, Valeas, Malesci Guidotti, Boehringer Ingelheim, Sanofi, GSK, Novartis, Stallergenes-Greer. CS received fees for consulting/speakers (AbbVie, Amgen, Alfa-Sigma, Biogen, Eli-Lilly, Galapagos, Janssen, Novartis, Pfizer, SOBI) and Research support (AbbVie, Amgen, Pfizer). The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.