Characteristics of autonomic dysfunction in neuronal intranuclear inclusion disease.
SCOPA-AUT
assessment
autonomic dysfunction
autonomic symptoms
neuronal intranuclear inclusion disease
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2023
2023
Historique:
received:
20
02
2023
accepted:
22
05
2023
medline:
30
6
2023
pubmed:
30
6
2023
entrez:
30
6
2023
Statut:
epublish
Résumé
This study aimed to investigate the features of autonomic dysfunction (AutD) in a large cohort of patients with neuronal intranuclear inclusion disease (NIID). A total of 122 patients with NIID and 122 controls were enrolled. All participants completed the Scales for Outcomes in Parkinson's Disease-Autonomic Questionnaire (SCOPA-AUT) and genetic screening for GGC expanded repeats within the 94.26% of patients had AutD. Compared with controls, patients had more severe AutD in total SCOPA-AUT, gastrointestinal, urinary, cardiovascular, thermoregulatory, pupillomotor and sexual domains (all SCOPA-AUT can be used as a diagnostic and quantitative tool for autonomic dysfunction in NIID. The high prevalence of AutD in patients suggests that NIID diagnosis should be considered in patients with AutD, especially in those with unexplained AutD alone. AutD in patients is related to age, disease duration, impairment of daily living ability, and psychiatric symptoms.
Sections du résumé
Background
UNASSIGNED
This study aimed to investigate the features of autonomic dysfunction (AutD) in a large cohort of patients with neuronal intranuclear inclusion disease (NIID).
Methods
UNASSIGNED
A total of 122 patients with NIID and 122 controls were enrolled. All participants completed the Scales for Outcomes in Parkinson's Disease-Autonomic Questionnaire (SCOPA-AUT) and genetic screening for GGC expanded repeats within the
Results
UNASSIGNED
94.26% of patients had AutD. Compared with controls, patients had more severe AutD in total SCOPA-AUT, gastrointestinal, urinary, cardiovascular, thermoregulatory, pupillomotor and sexual domains (all
Conclusion
UNASSIGNED
SCOPA-AUT can be used as a diagnostic and quantitative tool for autonomic dysfunction in NIID. The high prevalence of AutD in patients suggests that NIID diagnosis should be considered in patients with AutD, especially in those with unexplained AutD alone. AutD in patients is related to age, disease duration, impairment of daily living ability, and psychiatric symptoms.
Identifiants
pubmed: 37388545
doi: 10.3389/fneur.2023.1168904
pmc: PMC10300412
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1168904Informations de copyright
Copyright © 2023 Zhou, Tian, Zhang, Jiao, Liao, Zhou, Xiao, Xue, Duan, Tang and Shen.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
Brain. 2016 Dec;139(Pt 12):3170-3186
pubmed: 27797808
J Neurol Sci. 2018 Sep 15;392:89-93
pubmed: 30031993
J Neurol Neurosurg Psychiatry. 2022 Dec;93(12):1289-1298
pubmed: 36150844
Acta Neuropathol. 1968 Jan 2;10(1):54-73
pubmed: 4295804
J Child Neurol. 2004 Jan;19(1):59-62
pubmed: 15032387
Mov Disord. 2004 Nov;19(11):1306-12
pubmed: 15390007
J Neurol. 2020 Jul;267(7):1941-1951
pubmed: 32170444
Arch Neurol. 2002 Aug;59(8):1319-26
pubmed: 12164731
Gastroenterology. 1992 Feb;102(2):684-91
pubmed: 1310083
Eur J Neurol. 2010 Aug;17(8):1068-74
pubmed: 20192977
Clin Neuropathol. 2020 Jan/Feb;39(1):7-18
pubmed: 31661069
J Parkinsons Dis. 2022;12(3):1059-1067
pubmed: 35124662
J Neuropathol Exp Neurol. 1980 Mar;39(2):107-30
pubmed: 6154779
Acta Neuropathol. 1981;54(2):113-9
pubmed: 6264727
Neurology. 2000 Dec 12;55(11):1621-6
pubmed: 11113214
Eur J Neurol. 2010 Feb;17(2):194-201
pubmed: 19780808
Age Ageing. 1996 Mar;25(2):113-20
pubmed: 8670538
Neurology. 1994 Dec;44(12):2308-14
pubmed: 7991117
J Am Geriatr Soc. 2005 Apr;53(4):695-9
pubmed: 15817019
Front Aging Neurosci. 2021 Nov 30;13:761044
pubmed: 34916924
Nat Genet. 2019 Aug;51(8):1222-1232
pubmed: 31332380
Neuropathology. 2003 Dec;23(4):351-9
pubmed: 14719553
Am J Hum Genet. 2019 Jul 3;105(1):166-176
pubmed: 31178126
Neurology. 2005 Nov 22;65(10):1538-43
pubmed: 16301479
Parkinsonism Relat Disord. 2012 Jun;18(5):612-5
pubmed: 22236582
Neurology. 1986 Jun;36(6):785-90
pubmed: 3010181
Neurology. 2007 Jul 24;69(4):333-41
pubmed: 17646625
J Med Genet. 2019 Nov;56(11):758-764
pubmed: 31413119
Geriatr Gerontol Int. 2016 Mar;16 Suppl 1:51-6
pubmed: 27018283
Nat Genet. 2019 Aug;51(8):1215-1221
pubmed: 31332381