Murine models to study human NK cells in human solid tumors.
human-in-mouse model
humanized mice
natural killer cells
solid tumor
tumor immunity
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
20
04
2023
accepted:
02
06
2023
medline:
3
7
2023
pubmed:
30
6
2023
entrez:
30
6
2023
Statut:
epublish
Résumé
Since the first studies, the mouse models have provided crucial support for the most important discoveries on NK cells, on their development, function, and circulation within normal and tumor tissues. Murine tumor models were initially set to study murine NK cells, then, ever more sophisticated human-in-mice models have been developed to investigate the behavior of human NK cells and minimize the interferences from the murine environment. This review presents an overview of the models that have been used along time to study NK cells, focusing on the most popular NOG and NSG models, which work as recipients for the preparation of human-in-mice tumor models, the study of transferred human NK cells, and the evaluation of various enhancers of human NK cell function, including cytokines and chimeric molecules. Finally, an overview of the next generation humanized mice is also provided along with a discussion on how traditional and innovative
Identifiants
pubmed: 37388731
doi: 10.3389/fimmu.2023.1209237
pmc: PMC10301748
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1209237Informations de copyright
Copyright © 2023 Parodi, Astigiano, Carrega, Pietra, Vitale, Damele, Grottoli, Guevara Lopez, Ferracini, Bertolini, Roato, Vitale and Orecchia.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer VL declared a shared affiliation with the authors RF and IR to the handling editor at the time of review.
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