Proteomics of immune cells from liver tumors reveals immunotherapy targets.
CRISPR in mouse T cells
HCC
NK cells
T cells
cancer immunotherapy
liver cancer
macrophages
mass spectrometry-based proteomics
profiles of tumor-infiltrating immune cells
proteomes
Journal
Cell genomics
ISSN: 2666-979X
Titre abrégé: Cell Genom
Pays: United States
ID NLM: 9918284260106676
Informations de publication
Date de publication:
14 Jun 2023
14 Jun 2023
Historique:
received:
28
09
2022
revised:
13
03
2023
accepted:
02
05
2023
medline:
30
6
2023
pubmed:
30
6
2023
entrez:
30
6
2023
Statut:
epublish
Résumé
Elucidating the mechanisms by which immune cells become dysfunctional in tumors is critical to developing next-generation immunotherapies. We profiled proteomes of cancer tissue as well as monocyte/macrophages, CD4
Identifiants
pubmed: 37388918
doi: 10.1016/j.xgen.2023.100331
pii: S2666-979X(23)00099-X
pmc: PMC10300607
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100331Informations de copyright
© 2023 The Author(s).
Déclaration de conflit d'intérêts
The Geiger laboratory received funding from F. Hoffmann-La Roche AG for this study. M.F., T.N., H.M., and N.P. were or are employees and shareholders of F. Hoffmann-La Roche AG. R.G. is a co-founder of Encentrio Therapeutics and a member of the scientific executive board. L.T.J. is a co-founder and former board member of Cimeio Therapeutics AG.
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