The SHELTER Trial of Transplanting Hepatitis C Virus-Infected Lungs Into Uninfected Recipients.
Journal
Transplantation direct
ISSN: 2373-8731
Titre abrégé: Transplant Direct
Pays: United States
ID NLM: 101651609
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
received:
23
11
2022
revised:
11
04
2023
accepted:
05
05
2023
medline:
30
6
2023
pubmed:
30
6
2023
entrez:
30
6
2023
Statut:
epublish
Résumé
SHELTER is a trial of transplanting lungs from deceased donors with hepatitis C virus (HCV) infection into HCV-negative candidates (sponsor: Merck; NCT03724149). Few trials have reported outcomes using thoracic organs from HCV-RNA This study is a single-arm trial of 10 lung transplants at a single center. Patients were included who were between 18 and 67 y of age and waitlisted for lung-only transplant. Patients were excluded who had evidence of liver disease. Primary outcome was HCV cure (sustained virologic response 12 wk after completing antiviral therapy). Recipients longitudinally reported QOL using the validated RAND-36 instrument. We also applied advanced methods to match HCV-RNA Between November 2018 and November 2020, 18 patients were consented and opted-in for HCV-RNA SHELTER adds important evidence regarding the safety of transplanting HCV-RNA
Identifiants
pubmed: 37389016
doi: 10.1097/TXD.0000000000001504
pmc: PMC10306429
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e1504Subventions
Organisme : NIDDK NIH HHS
ID : K08 DK127250
Pays : United States
Informations de copyright
Copyright © 2023 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc.
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