Towards Characterization of Skin Melanoma in the Clinic by Electron Paramagnetic Resonance (EPR) Spectroscopy and Imaging of Melanin.
Cancer
Clinical EPR
EPR
ESR
In vivo
Low frequency
Melanin
Melanoma
Mice
Patients
Journal
Molecular imaging and biology
ISSN: 1860-2002
Titre abrégé: Mol Imaging Biol
Pays: United States
ID NLM: 101125610
Informations de publication
Date de publication:
30 Jun 2023
30 Jun 2023
Historique:
received:
28
04
2023
accepted:
23
06
2023
revised:
05
06
2023
medline:
30
6
2023
pubmed:
30
6
2023
entrez:
30
6
2023
Statut:
aheadofprint
Résumé
The incidence of melanoma is continuously increasing over time. Melanoma is the most aggressive skin cancer, significantly reducing quality of life and survival rates of patients at advanced stages. Therefore, early diagnosis remains the key to change the prognosis of patients with melanoma. In this context, advanced technologies are under evaluation to increase the accuracy of the diagnostic, to better characterize the lesions and visualize their possible invasiveness in the epidermis. Among the innovative methods, because melanin is paramagnetic, clinical low frequency electron paramagnetic resonance (EPR) that characterizes the melanin content in the lesion has the potential to be an adjunct diagnostic method of melanoma. In this review, we first summarize the challenges faced by dermatologists and oncologists in melanoma diagnostic and management. We also provide a historical perspective on melanin detection with a focus on EPR spectroscopy/imaging of melanomas. We describe key elements that allow EPR to move from in vitro studies to in vivo and finally to patients for melanoma studies. Finally, we provide a critical view on challenges to meet to make EPR operational in the clinic to characterize pigmented lesions.
Identifiants
pubmed: 37389709
doi: 10.1007/s11307-023-01836-3
pii: 10.1007/s11307-023-01836-3
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fonds De La Recherche Scientifique - FNRS
ID : 2.5010.12
Organisme : Fonds De La Recherche Scientifique - FNRS
ID : U.N029.21
Organisme : Fondation contre le Cancer
ID : 2020-105
Informations de copyright
© 2023. The Author(s).
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