Adenovirus vector produced Zika virus-like particles induce a long-lived neutralising antibody response in mice.

Animals Mice Zika Virus Antibodies, Neutralizing Zika Virus Infection Antibodies, Viral Viral Vaccines Adenoviridae
Neutralising antibodies Vaccine Virus-like particle Zika virus

Journal

Vaccine
ISSN: 1873-2518
Titre abrégé: Vaccine
Pays: Netherlands
ID NLM: 8406899

Informations de publication

Date de publication:
25 07 2023
Historique:
received: 08 03 2023
revised: 18 06 2023
accepted: 21 06 2023
medline: 31 7 2023
pubmed: 1 7 2023
entrez: 30 6 2023
Statut: ppublish

Résumé

Countermeasures against Zika virus (ZIKV) epidemics are urgently needed. In this study we generated a ZIKV virus-like particle (VLP) based vaccine candidate and assessed the immunogenicity of these particles in mice. The ZIKV-VLPs were morphologically similar to ZIKV by electron microscopy and were recognized by anti-Flavivirus neutralising antibodies. We observed that a single dose of unadjuvanted ZIKV-VLPs, or inactivated ZIKV, generated an immune response that lasted over 6 months, but did not neutralize ZIKV infection of cells in vitro. However, when we co-administered the ZIKV VLPs with either Aluminium hydroxide (Alhydrogel®; Alum), AddaVax or Pam

Identifiants

DOI: 10.1016/j.vaccine.2023.06.068 PMID: 37391311
pubmed: 37391311
pii: S0264-410X(23)00757-0
doi: 10.1016/j.vaccine.2023.06.068
pii:
doi:

Substances chimiques

Antibodies, Neutralizing 0
aluminum sulfate 34S289N54E
Antibodies, Viral 0
Viral Vaccines 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4888-4898

Informations de copyright

Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Julio Carrera (J)

Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty for Infection and Immunity, Parkville, Melbourne, VIC 3010, Australia; Institute of Vector-Borne Diseases, Monash University, Clayton, VIC 3800, Australia.

Turgut E Aktepe (TE)

Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty for Infection and Immunity, Parkville, Melbourne, VIC 3010, Australia.

Linda Earnest (L)

Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty for Infection and Immunity, Parkville, Melbourne, VIC 3010, Australia.

Dale Christiansen (D)

Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty for Infection and Immunity, Parkville, Melbourne, VIC 3010, Australia.

Adam K Wheatley (AK)

Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty for Infection and Immunity, Parkville, Melbourne, VIC 3010, Australia.

Hyon-Xhi Tan (HX)

Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty for Infection and Immunity, Parkville, Melbourne, VIC 3010, Australia.

Amy W Chung (AW)

Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty for Infection and Immunity, Parkville, Melbourne, VIC 3010, Australia.

Simon Collett (S)

School of Science, College of Science, Engineering and Health, RMIT University, Melbourne, VIC 3000, Australia.

Kirsty McPherson (K)

Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty for Infection and Immunity, Parkville, Melbourne, VIC 3010, Australia.

Joseph Torresi (J)

Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty for Infection and Immunity, Parkville, Melbourne, VIC 3010, Australia.

Jason M Mackenzie (JM)

Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty for Infection and Immunity, Parkville, Melbourne, VIC 3010, Australia. Electronic address: jason.mackenzie@unimelb.edu.au.

Cameron P Simmons (CP)

Institute of Vector-Borne Diseases, Monash University, Clayton, VIC 3800, Australia. Electronic address: cameron.simmons@worldmosquito.org.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Adenovirus vector produced Zika virus-like...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Adenovirus vector produced Zika virus-like...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Flaviviridae › Flavivirus › Virus Zika › Adenovirus vector produced Zika virus-like...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps neutralisants › Adenovirus vector produced Zika virus-like...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Infections à Flaviviridae › Infections à flavivirus › Infection par le virus Zika › Adenovirus vector produced Zika virus-like...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps antiviraux › Adenovirus vector produced Zika virus-like...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins antiviraux › Adenovirus vector produced Zika virus-like...
questionsmedicales.fr › Virus › Virus à ADN › Adenoviridae › Adenovirus vector produced Zika virus-like...