Serum DHEA and Testosterone Levels Associate Inversely With Coronary Artery Calcification in Elderly Men.
atherosclerosis
coronary artery calcification
men
sex steroids
Journal
The Journal of clinical endocrinology and metabolism
ISSN: 1945-7197
Titre abrégé: J Clin Endocrinol Metab
Pays: United States
ID NLM: 0375362
Informations de publication
Date de publication:
17 Nov 2023
17 Nov 2023
Historique:
received:
11
01
2023
medline:
20
11
2023
pubmed:
1
7
2023
entrez:
1
7
2023
Statut:
ppublish
Résumé
Epidemiological and preclinical data support cardiovascular, mainly protective, effects of sex steroids in men, but the mechanisms underlying the cardiovascular actions of sex steroids are poorly understood. Vascular calcification parallels the development of atherosclerosis, but is increasingly recognized as a diversified, highly regulated process, which itself may have pathophysiological importance for clinical cardiovascular events. To investigate the association between serum sex steroids and coronary artery calcification (CAC) in elderly men. We used gas chromatography tandem mass spectrometry to analyze a comprehensive sex steroid profile, including levels of dehydroepiandrosterone (DHEA), androstenedione, estrone, testosterone, estradiol, and dihydrotestosterone, in men from the population-based AGES-Reykjavik study (n = 1287, mean 76 years). Further, sex hormone-binding globulin (SHBG) was assayed and bioavailable hormone levels calculated. CAC score was determined by computed tomography. The main outcome measures were cross-sectional associations between dehydroepiandrosterone, androstenedione, estrone, testosterone, dihydrotestosterone, and estradiol and quintiles of CAC. Serum levels of DHEA, androstenedione, testosterone, dihydrotestosterone, and bioavailable testosterone showed significant inverse associations with CAC, while estrone, estradiol, bioavailable estradiol, and SHBG did not. DHEA, testosterone, and bioavailable testosterone remained associated with CAC after adjustment for traditional cardiovascular risk factors. In addition, our results support partially independent associations between adrenal-derived DHEA and testes-derived testosterone and CAC. Serum levels of DHEA and testosterone are inversely associated with CAC in elderly men, partially independently from each other. These results raise the question whether androgens from both the adrenals and the testes may contribute to male cardiovascular health.
Identifiants
pubmed: 37391895
pii: 7194268
doi: 10.1210/clinem/dgad351
pmc: PMC10655543
doi:
Substances chimiques
Androstenedione
409J2J96VR
Dehydroepiandrosterone
459AG36T1B
Dihydrotestosterone
08J2K08A3Y
Estradiol
4TI98Z838E
Estrone
2DI9HA706A
Sex Hormone-Binding Globulin
0
Testosterone
3XMK78S47O
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3272-3279Subventions
Organisme : NIH HHS
ID : N01-AG-1-2100
Pays : United States
Informations de copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society.
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