Perspective on the current state of the LRRK2 field.
Journal
NPJ Parkinson's disease
ISSN: 2373-8057
Titre abrégé: NPJ Parkinsons Dis
Pays: United States
ID NLM: 101675390
Informations de publication
Date de publication:
01 Jul 2023
01 Jul 2023
Historique:
received:
13
02
2023
accepted:
05
06
2023
medline:
2
7
2023
pubmed:
2
7
2023
entrez:
1
7
2023
Statut:
epublish
Résumé
Almost 2 decades after linking LRRK2 to Parkinson's disease, a vibrant research field has developed around the study of this gene and its protein product. Recent studies have begun to elucidate molecular structures of LRRK2 and its complexes, and our understanding of LRRK2 has continued to grow, affirming decisions made years ago to therapeutically target this enzyme for PD. Markers of LRRK2 activity, with potential to monitor disease progression or treatment efficacy, are also under development. Interestingly, there is a growing understanding of the role of LRRK2 outside of the central nervous system in peripheral tissues such as gut and immune cells that may also contribute to LRRK2 mediated pathology. In this perspective, our goal is to take stock of LRRK2 research by discussing the current state of knowledge and critical open questions in the field.
Identifiants
pubmed: 37393318
doi: 10.1038/s41531-023-00544-7
pii: 10.1038/s41531-023-00544-7
pmc: PMC10314919
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
104Subventions
Organisme : NIA NIH HHS
ID : R21 AG077269
Pays : United States
Informations de copyright
© 2023. The Author(s).
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