Bacterial Community Modifies Host Genetics Effect on Early Childhood Caries.
dental caries
epidemiology
genomics
microbiome
pediatrics
saliva
Journal
Journal of dental research
ISSN: 1544-0591
Titre abrégé: J Dent Res
Pays: United States
ID NLM: 0354343
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
pmc-release:
01
09
2024
medline:
22
8
2023
pubmed:
3
7
2023
entrez:
3
7
2023
Statut:
ppublish
Résumé
By age 5, approximately one-fifth of children have early childhood caries (ECC). Both the oral microbiome and host genetics are thought to influence susceptibility. Whether the oral microbiome modifies genetic susceptibility to ECC has not been tested. We test whether the salivary bacteriome modifies the association of a polygenic score (PGS, a score derived from genomic data that summarizes genetic susceptibility to disease) for primary tooth decay on ECC in the Center for Oral Health Research in Appalachia 2 longitudinal birth cohort. Children were genotyped using the Illumina Multi-Ethnic Genotyping Array and underwent annual dental examinations. We constructed a PGS for primary tooth decay using weights from an independent, genome-wide association meta-analysis. Using Poisson regression, we tested for associations between the PGS (high versus low) and ECC incidence, adjusting for demographic characteristics (
Identifiants
pubmed: 37395259
doi: 10.1177/00220345231175356
pmc: PMC10552462
doi:
Banques de données
figshare
['10.6084/m9.figshare.21890670']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1098-1105Subventions
Organisme : NIDCR NIH HHS
ID : F31 DE029992
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE014899
Pays : United States
Commentaires et corrections
Type : UpdateOf
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