LGG-1/GABARAP lipidation is not required for autophagy and development in
Atg8/LC3/GABARAP
C. elegans
CRISPR-Cas9
S. cerevisiae
autophagy
cell biology
development
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
03 07 2023
03 07 2023
Historique:
received:
22
12
2022
accepted:
30
06
2023
medline:
14
7
2023
pubmed:
3
7
2023
entrez:
3
7
2023
Statut:
epublish
Résumé
The ubiquitin-like proteins Atg8/LC3/GABARAP are required for multiple steps of autophagy, such as initiation, cargo recognition and engulfment, vesicle closure and degradation. Most of LC3/GABARAP functions are considered dependent on their post-translational modifications and their association with the autophagosome membrane through a conjugation to a lipid, the phosphatidyl-ethanolamine. Contrarily to mammals,
Identifiants
pubmed: 37395461
doi: 10.7554/eLife.85748
pii: 85748
pmc: PMC10338037
doi:
pii:
Substances chimiques
Microtubule-Associated Proteins
0
GABARAP protein, human
0
Apoptosis Regulatory Proteins
0
LGG-2 protein, C elegans
0
Caenorhabditis elegans Proteins
0
LGG-1 protein, C elegans
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Research Council
ID : ERC-CoG-616499
Pays : International
Informations de copyright
© 2023, Leboutet et al.
Déclaration de conflit d'intérêts
RL, CL, LM, MP, GQ, MR, MC, TH, EC, CL, RL No competing interests declared
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