Ribose 5-phosphate: the key metabolite bridging the metabolisms of nucleotides and amino acids during stringent response in
(p)ppGpp
amino acid
nucleotide
ribose 5'-phosphate
stringent response
Journal
Microbial cell (Graz, Austria)
ISSN: 2311-2638
Titre abrégé: Microb Cell
Pays: Austria
ID NLM: 101632887
Informations de publication
Date de publication:
03 Jul 2023
03 Jul 2023
Historique:
received:
01
05
2023
revised:
18
05
2023
accepted:
18
05
2023
medline:
3
7
2023
pubmed:
3
7
2023
entrez:
3
7
2023
Statut:
epublish
Résumé
The bacterial stringent response and its effector alarmone guanosine penta- or tetra - phosphates (p)ppGpp are vital for bacterial tolerance and survival of various stresses in environments (including antibiotics) and host cells (virulence). (p)ppGpp does so by binding to its numerous target proteins and reprograming bacterial transcriptome to tune down the synthesis of nucleotides and rRNA/tRNA, and up-regulate amino acid biosynthesis genes. Recent identification of more novel (p)ppGpp direct binding proteins in
Identifiants
pubmed: 37395996
doi: 10.15698/mic2023.07.799
pii: MIC0273E111
pmc: PMC10311079
doi:
Types de publication
Journal Article
Langues
eng
Pagination
141-144Informations de copyright
Copyright: © 2023 Grucela et al.
Déclaration de conflit d'intérêts
Conflict of Interest: The authors have no conflict of interest to disclose.
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