The role of sex hormones in targeting stress-induced tobacco craving, stress-reactivity, and smoking with guanfacine among women who smoke.
Cigarettes
Estradiol
Guanfacine
Progesterone
Stress-reactivity
Tobacco
Women
Journal
Addiction neuroscience
ISSN: 2772-3925
Titre abrégé: Addict Neurosci
Pays: Netherlands
ID NLM: 9918367980706676
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
medline:
3
7
2023
pubmed:
3
7
2023
entrez:
3
7
2023
Statut:
ppublish
Résumé
Women who smoke are particularly vulnerable to tobacco craving, smoking behaviors, and relapse in the context of stress when compared to men who smoke. One factor in this sex difference may be sex hormones, including estradiol and progesterone; however, smoking cessation medication trials often do not explore the impact of sex hormones on drug effects. This secondary analysis of a double-blind, placebo-controlled study explored the impact of levels of actual estradiol and progesterone on guanfacine, a noradrenergic α2a agonist, which attenuates stress-induced smoking behaviors in women. Women who smoke (
Identifiants
pubmed: 37396408
doi: 10.1016/j.addicn.2023.100084
pmc: PMC10311966
mid: NIHMS1909950
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIAAA NIH HHS
ID : P01 AA027473
Pays : United States
Organisme : NIDA NIH HHS
ID : P50 DA033945
Pays : United States
Organisme : NIAAA NIH HHS
ID : U54 AA027989
Pays : United States
Déclaration de conflit d'intérêts
Declaration of Competing Interest All authors declare that they have no conflicts of interest.
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