Effect of citalopram and sertraline on the expression of miRNA- 124, 132, and 16 and their protein targets in patients with depression.
Citalopram
Depression
MiRNAs
SSRIs
Sertraline
Journal
Iranian journal of basic medical sciences
ISSN: 2008-3866
Titre abrégé: Iran J Basic Med Sci
Pays: Iran
ID NLM: 101517966
Informations de publication
Date de publication:
2023
2023
Historique:
received:
02
07
2022
accepted:
06
03
2023
medline:
3
7
2023
pubmed:
3
7
2023
entrez:
3
7
2023
Statut:
ppublish
Résumé
This study aimed to evaluate the effect of SSRIs on the expression of miRNAs and their protein targets. In a 100 day open-label study of citalopram (n=25) and sertraline (n=25), levels of miRNA 16, 132, and 124 and glucocorticoid receptor (GR), Brain-derived neurotrophic factor (BDNF), and serotonin transporter (SERT) protein expression were measured by QRT-PCR and western blot in healthy control (n=20), patients with depression at the baseline, and same patients after 100 days of treatment. Expression levels of GR and BDNF proteins were lower in the depressed group before treatment as compared with the healthy group ( This elucidated the relationship between antidepressant treatment and the expression of different microRNA that control gene expression in various pathways involved in depressed patients. Receiving SSRI can affect the level of these proteins and their relevant microRNAs.
Identifiants
pubmed: 37396946
doi: 10.22038/IJBMS.2023.66496.14595
pmc: PMC10311976
doi:
Types de publication
Journal Article
Langues
eng
Pagination
820-829Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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