Do polygenic indices capture "direct" effects on child externalizing behavior? Within-family analyses in two longitudinal birth cohorts.

Development Direct Genetic Effects Externalizing Polygenic Index

Journal

medRxiv : the preprint server for health sciences
Titre abrégé: medRxiv
Pays: United States
ID NLM: 101767986

Informations de publication

Date de publication:
04 Jun 2023
Historique:
pubmed: 3 7 2023
medline: 3 7 2023
entrez: 3 7 2023
Statut: epublish

Résumé

Behaviors and disorders characterized by difficulties with self-regulation, such as problematic substance use, antisocial behavior, and symptoms of attention-deficit/hyperactivity disorder (ADHD), incur high costs for individuals, families, and communities. These externalizing behaviors often appear early in the life course and can have far-reaching consequences. Researchers have long been interested in direct measurements of genetic risk for externalizing behaviors, which can be incorporated alongside other known risk factors to improve efforts at early identification and intervention. In a preregistered analysis drawing on data from the Environmental Risk (E-Risk) Longitudinal Twin Study (

Identifiants

DOI: 10.1101/2023.05.31.23290802 PMID: 37398155 PMC: PMC10312898
pubmed: 37398155
doi: 10.1101/2023.05.31.23290802
pmc: PMC10312898
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NIDA NIH HHS
ID : R01 DA050721
Pays : United States
Organisme : Medical Research Council
ID : G1002190
Pays : United Kingdom
Organisme : NIDA NIH HHS
ID : DP1 DA054394
Pays : United States
Organisme : NIDA NIH HHS
ID : P50 DA037844
Pays : United States
Organisme : Medical Research Council
ID : MR/X010791/1
Pays : United Kingdom
Organisme : NICHD NIH HHS
ID : R01 HD092548
Pays : United States

Auteurs

Peter T Tanksley (PT)

Department of Psychology, The University of Texas at Austin, Austin, TX, USA.
Population Research Center, The University of Texas at Austin, Austin, TX, USA.

Sarah J Brislin (SJ)

Department of Psychiatry, Rutgers Robert Wood Johnson Medical School, Newark, NJ, USA.

Jasmin Wertz (J)

Department of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Department of Psychology, University of Edinburgh, Edinburgh, UK.

Ronald de Vlaming (R)

Department of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

Natasia S Courchesne-Krak (NS)

Department of Psychiatry, University of California San Diego, San Diego, CA, USA.

Travis T Mallard (TT)

Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.

Laurel L Raffington (LL)

Department of Psychology, The University of Texas at Austin, Austin, TX, USA.
Population Research Center, The University of Texas at Austin, Austin, TX, USA.
Max Planck Institute for Human Development, Berlin, Germany.

Richard Karlsson Linnér (RK)

Department of Economics, Leiden Law School, Leiden University, the Netherlands.

Philipp Koellinger (P)

Department of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

Abraham Palmer (A)

Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA.

Alexandra Sanchez-Roige (A)

Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Irwin Waldman (I)

Department of Psychology, Emory University, Atlanta, GA, USA.

Danielle Dick (D)

Department of Psychiatry, Rutgers Robert Wood Johnson Medical School, Newark, NJ, USA.

Terrie E Moffitt (TE)

Department of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Center for the Study of Population Health & Aging, Duke University Population Research Institute, Durham, NC, USA.
Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.
Department of Psychology, University of Oslo, Oslo, Norway.
Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

Avshalom Caspi (A)

Department of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Center for the Study of Population Health & Aging, Duke University Population Research Institute, Durham, NC, USA.
Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.
Department of Psychology, University of Oslo, Oslo, Norway.
Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

K Paige Harden (KP)

Department of Psychology, The University of Texas at Austin, Austin, TX, USA.
Population Research Center, The University of Texas at Austin, Austin, TX, USA.

Classifications MeSH