Distinct Local and Global Functions of Aβ Low-Threshold Mechanoreceptors in Mechanical Pain Transmission.
Aβ-LTMRs
Somatosensation
behavioral assays
high-speed imaging
inflammatory pain
intersectional genetics
mechanical hyperalgesia
mechanical pain
neuropathic pain
opto-tagged electrophysiological recordings
optogenetics
Journal
Research square
Titre abrégé: Res Sq
Pays: United States
ID NLM: 101768035
Informations de publication
Date de publication:
15 Jun 2023
15 Jun 2023
Historique:
pubmed:
3
7
2023
medline:
3
7
2023
entrez:
3
7
2023
Statut:
epublish
Résumé
The roles of Aβ low-threshold mechanoreceptors (LTMRs) in transmitting mechanical hyperalgesia and in alleviating chronic pain have been of great interest but remain contentious. Here we utilized intersectional genetic tools, optogenetics, and high-speed imaging to specifically examine functions of
Identifiants
pubmed: 37398333
doi: 10.21203/rs.3.rs-2939309/v1
pmc: PMC10312941
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE018661
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS083702
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS109059
Pays : United States
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.