Single-tier point-of-care serodiagnosis of Lyme disease.

Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
14 Jun 2023
Historique:
pubmed: 3 7 2023
medline: 3 7 2023
entrez: 3 7 2023
Statut: epublish

Résumé

Point-of-care (POC) serological testing provides actionable information for several difficult to diagnose illnesses, empowering distributed health systems. Accessible and adaptable diagnostic platforms that can assay the repertoire of antibodies formed against pathogens are essential to drive early detection and improve patient outcomes. Here, we report a POC serologic test for Lyme disease (LD), leveraging synthetic peptides tuned to be highly specific to the LD antibody repertoire across patients and compatible with a paper-based platform for rapid, reliable, and cost-effective diagnosis. A subset of antigenic epitopes conserved across

Identifiants

DOI: 10.1101/2023.06.14.544508 PMID: 37398357 PMC: PMC10312703
pubmed: 37398357
doi: 10.1101/2023.06.14.544508
pmc: PMC10312703
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NIAID NIH HHS
ID : R44 AI150060
Pays : United States

Auteurs

Rajesh Ghosh (R)

Bioengineering Department, University of California, Los Angeles, CA 90095 USA.

Hyou-Arm Joung (HA)

Electrical & Computer Engineering Department, University of California, Los Angeles, CA 90095 USA.
California NanoSystems Institute (CNSI), University of California, Los Angeles, CA 90095 USA.

Artem Goncharov (A)

Electrical & Computer Engineering Department, University of California, Los Angeles, CA 90095 USA.
California NanoSystems Institute (CNSI), University of California, Los Angeles, CA 90095 USA.

Barath Palanisamy (B)

Bioengineering Department, University of California, Los Angeles, CA 90095 USA.

Kevin Ngo (K)

Bioengineering Department, University of California, Los Angeles, CA 90095 USA.

Katarina Pejcinovic (K)

Bioengineering Department, University of California, Los Angeles, CA 90095 USA.

Nicole Krockenberger (N)

Bioengineering Department, University of California, Los Angeles, CA 90095 USA.

Elizabeth J Horn (EJ)

Lyme Disease Biobank, Portland, Oregon 97221, United States.

Omai B Garner (OB)

Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095 USA.

Ezdehar Ghazal (E)

Department of Pathology, Microbiology, and Immunology, New York Medical College, Valhalla, New York 10595, United States.

Andrew O'Kula (A)

Department of Pathology, Microbiology, and Immunology, New York Medical College, Valhalla, New York 10595, United States.

Paul M Arnaboldi (PM)

Department of Pathology, Microbiology, and Immunology, New York Medical College, Valhalla, New York 10595, United States.
Biopeptides, Corp. East Setauket, NY 11733.

Raymond J Dattwyler (RJ)

Department of Pathology, Microbiology, and Immunology, New York Medical College, Valhalla, New York 10595, United States.
Biopeptides, Corp. East Setauket, NY 11733.

Aydogan Ozcan (A)

Bioengineering Department, University of California, Los Angeles, CA 90095 USA.
Electrical & Computer Engineering Department, University of California, Los Angeles, CA 90095 USA.
California NanoSystems Institute (CNSI), University of California, Los Angeles, CA 90095 USA.
Department of Surgery, University of California, Los Angeles, CA 90095 USA.

Dino Di Carlo (D)

Bioengineering Department, University of California, Los Angeles, CA 90095 USA.
California NanoSystems Institute (CNSI), University of California, Los Angeles, CA 90095 USA.
Department of Mechanical Engineering, University of California, Los Angeles, CA 90095 USA.

Classifications MeSH