Circulating lipid profiles are associated with cross-sectional and longitudinal changes of central biomarkers for Alzheimer's disease.

Journal

medRxiv : the preprint server for health sciences
Titre abrégé: medRxiv
Pays: United States
ID NLM: 101767986

Informations de publication

Date de publication:
21 Jun 2023
Historique:
pubmed: 3 7 2023
medline: 3 7 2023
entrez: 3 7 2023
Statut: epublish

Résumé

Investigating the association of lipidome profiles with central Alzheimer's disease (AD) biomarkers, including amyloid/tau/neurodegeneration (A/T/N), can provide a holistic view between the lipidome and AD. We performed cross-sectional and longitudinal association analysis of serum lipidome profiles with AD biomarkers in the Alzheimer's Disease Neuroimaging Initiative cohort (N=1,395). We identified lipid species, classes, and network modules that were significantly associated with cross-sectional and longitudinal changes of A/T/N biomarkers for AD. Notably, we identified the lysoalkylphosphatidylcholine (LPC(O)) as associated with "A/N" biomarkers at baseline at lipid species, class, and module levels. Also, G

Identifiants

DOI: 10.1101/2023.06.12.23291054 PMID: 37398438 PMC: PMC10312871
pubmed: 37398438
doi: 10.1101/2023.06.12.23291054
pmc: PMC10312871
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG063744
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG059093
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG061359
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG057452
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG058942
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG051550
Pays : United States

Déclaration de conflit d'intérêts

CONFLICT OF INTERESTS Dr. Kaddurah-Daouk in an inventor on a series of patents on use of metabolomics for the diagnosis and treatment of CNS diseases and holds equity in Metabolon Inc., Chymia LLC and PsyProtix.

Auteurs

Jun Pyo Kim (JP)

Center for Neuroimaging, Radiology and Imaging Sciences, and the Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Department of Neurology, Samsung Medical Center, Seoul, Korea.

Kwangsik Nho (K)

Center for Neuroimaging, Radiology and Imaging Sciences, and the Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Tingting Wang (T)

Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Baker Department of Cardiometabolic Health, University of Melbourne, Victoria, Australia.

Kevin Huynh (K)

Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Baker Department of Cardiometabolic Health, University of Melbourne, Victoria, Australia.
Department of Cardiovascular Research Translation and Implementation, La Trobe University, Melbourne, Australia.

Matthias Arnold (M)

Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.
Institute of Computational Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.

Shannon L Risacher (SL)

Center for Neuroimaging, Radiology and Imaging Sciences, and the Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Paula J Bice (PJ)

Center for Neuroimaging, Radiology and Imaging Sciences, and the Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Xianlin Han (X)

University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

Bruce S Kristal (BS)

Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, and Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA.

Colette Blach (C)

Duke Molecular Physiology Institute, Duke University, Durham, NC, USA.

Rebecca Baillie (R)

Rosa & Co LLC, San Carlos, CA, USA.

Gabi Kastenmüller (G)

Institute of Computational Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
German Center for Diabetes Research (DZD), Neuherberg, Germany.

Peter J Meikle (PJ)

Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Baker Department of Cardiometabolic Health, University of Melbourne, Victoria, Australia.
Department of Cardiovascular Research Translation and Implementation, La Trobe University, Melbourne, Australia.

Andrew J Saykin (AJ)

Center for Neuroimaging, Radiology and Imaging Sciences, and the Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Rima Kaddurah-Daouk (R)

Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.
Duke Institute of Brain Sciences, Duke University, Durham, NC, USA.
Department of Medicine, Duke University, Durham, NC, USA.

Classifications MeSH